Observing the natural history of amyotrophic lateral sclerosis in patients
A Registered Cohort Study on Amyotrophic Lateral Sclerosis
This study is looking at how amyotrophic lateral sclerosis (ALS) progresses in Chinese patients to better understand the disease and find out what might affect its course.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | First Affiliated Hospital of Fujian Medical University Academic / other |
| Locations | 1 site (Fuzhou, Fujian) |
| Trial ID | NCT04008329 on ClinicalTrials.gov |
What this trial studies
This observational cohort study focuses on amyotrophic lateral sclerosis (ALS), a motor neuron disease with no effective treatment. It aims to document the natural history of ALS in Chinese patients and identify factors that may influence disease progression. Additionally, the study will screen for ALS-related genetic mutations to explore potential novel disease-causing genes. By gathering comprehensive data, the study seeks to enhance understanding of ALS and its risk factors.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with amyotrophic lateral sclerosis, including those with progressive muscular atrophy, primary lateral sclerosis, or progressive bulbar palsy.
Not a fit: Patients with a history of serious head trauma or neuropsychiatric disease, or those who decline to participate, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of ALS, potentially guiding future therapeutic strategies.
How similar studies have performed: While this study focuses on a specific population and genetic factors, similar observational studies have provided valuable insights into ALS, suggesting potential for meaningful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Amyotrophic Lateral Sclerosis patients fulfilling the El Escorial criteria (including definite, probable and possible) * Progressive muscular atrophy * Primary lateral sclerosis * Progressive bulbar palsy Exclusion Criteria: * History of serious head trauma or neuropsychiatric disease * Decline to participate
Where this trial is running
Fuzhou, Fujian
- Department of Neurology, First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (Recruiting)
Study contacts
- Principal investigator: Ning Wang, MD,PhD — First Affiliated Hospital of Fujian Medical University
- Study coordinator: Qi-Jie Zhang, PhD
- Email: qijiezhang86@fjmu.edu.cn
- Phone: 086-591-87982772
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.