Collection of biological samples for diagnosing rare neurological diseases
Official title: Control Cohort CTRL COH
Run by Hospices Civils de Lyon · NCT05370079 · Data updated 2026-11-12
This study is collecting blood and spinal fluid samples from people with rare neurological diseases to see if they can find new markers that help diagnose these conditions more accurately.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Status | Recruiting |
| Started | August 8, 2023 |
| Main results expected | August 8, 2028 |
| Study ends | August 8, 2028 |
| Registry record updated | January 15, 2026 |
| Trial ID | NCT05370079 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study include patients diagnosed with Parkinson's disease, amyotrophic lateral sclerosis, glioblastoma, certain cancers without neurological disease, or rheumatoid arthritis.
✕Probably not a fit
Patients with neurological disorders that are compatible with paraneoplastic neurological syndrome or autoimmune encephalitis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on collecting biological samples, such as blood and cerebrospinal fluid, from patients with various neurological and autoimmune conditions. The aim is to identify new genetic biomarkers that could lead to more accurate diagnostic tools for autoimmune encephalitis and paraneoplastic neurological syndromes. By gathering samples from a diverse group of patients, the study seeks to enhance the understanding of these rare diseases and improve diagnostic capabilities.
Why it matters
Potential benefit: If successful, this research could lead to more precise and timely diagnoses for patients suffering from rare neurological diseases.
How similar studies have gone: While the approach of identifying new biomarkers is common, the specific focus on these rare diseases may present novel insights, as similar studies have had varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient with consent * patient with following disease: Parkinson's disease, Amyotrophic lateral sclerosis, Glioblastoma, cancer without neurological disease (pulmonary cancer, breast cancer, ovarian cancer, melanoma, thymoma), rheumatoid arthritis. Exclusion Criteria: * refusal consent * patient with neurological disorder compatible with paraneoplastic neurological syndrome or auto-immune encephalitis * patient under guardianship
Where it's running
-
Hospices Civils de Lyon
Bron, France Recruiting
Study contacts
- Principal investigator: Jerome Honnorat, Pr — Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes, Lyon, France
- Study coordinator: Jerome Honnorat, Pr
- Email: jerome.honnorat@chu-lyon.fr
- Phone: (33) 4 72 35 78 06
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.