Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Collection of biological samples for diagnosing rare neurological diseases

Official title: Control Cohort CTRL COH

Run by Hospices Civils de Lyon · NCT05370079 · Data updated 2026-11-12

This study is collecting blood and spinal fluid samples from people with rare neurological diseases to see if they can find new markers that help diagnose these conditions more accurately.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment350 (estimated)
SponsorHospices Civils de Lyon
Academic / other
Locations1 site (Bron)
StatusRecruiting
StartedAugust 8, 2023
Main results expectedAugust 8, 2028
Study endsAugust 8, 2028
Registry record updatedJanuary 15, 2026
Trial IDNCT05370079 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study include patients diagnosed with Parkinson's disease, amyotrophic lateral sclerosis, glioblastoma, certain cancers without neurological disease, or rheumatoid arthritis.

Probably not a fit

Patients with neurological disorders that are compatible with paraneoplastic neurological syndrome or autoimmune encephalitis may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on collecting biological samples, such as blood and cerebrospinal fluid, from patients with various neurological and autoimmune conditions. The aim is to identify new genetic biomarkers that could lead to more accurate diagnostic tools for autoimmune encephalitis and paraneoplastic neurological syndromes. By gathering samples from a diverse group of patients, the study seeks to enhance the understanding of these rare diseases and improve diagnostic capabilities.

Why it matters

Potential benefit: If successful, this research could lead to more precise and timely diagnoses for patients suffering from rare neurological diseases.

How similar studies have gone: While the approach of identifying new biomarkers is common, the specific focus on these rare diseases may present novel insights, as similar studies have had varying degrees of success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patient with consent
* patient with following disease: Parkinson's disease, Amyotrophic lateral sclerosis, Glioblastoma, cancer without neurological disease (pulmonary cancer, breast cancer, ovarian cancer, melanoma, thymoma), rheumatoid arthritis.

Exclusion Criteria:

* refusal consent
* patient with neurological disorder compatible with paraneoplastic neurological syndrome or auto-immune encephalitis
* patient under guardianship

Where it's running

  • Hospices Civils de Lyon
    Bron, France
    Recruiting

Study contacts

  • Principal investigator: Jerome Honnorat, Pr — Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes, Lyon, France
  • Study coordinator: Jerome Honnorat, Pr
  • Email: jerome.honnorat@chu-lyon.fr
  • Phone: (33) 4 72 35 78 06

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.