How interactive tasks change how people hear speech from people with ALS.

Assessing Perceptual Effects of Interactive Tasks

Not applicable Interventional Penn State University · NCT06828523

We will test whether people without speech disorders hear speech from people with ALS differently when the speech comes from interactive versus non-interactive tasks.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1300 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorPenn State University Academic / other
Locations1 site (University Park, Pennsylvania)
Trial IDNCT06828523 on ClinicalTrials.gov

What this trial studies

Remote naive listeners recruited via Prolific will listen to recorded vowels and consonants produced by people with ALS and age-matched control speakers in both interactive and non-interactive tasks. Listeners will indicate what they heard after passing a remote hearing screen; eligible participants are native monolingual American English speakers aged 18–65 with no reported speech, language, or neurological disorders and no prior experience communicating with people with dysarthria. The study plans to enroll 1,300 listeners to achieve 80% power and will analyze perceptual judgments using generalized mixed-effects regression to compare effects of context and speaker group. Participation is asynchronous and completed on each listener's own computer with headphones.

Who should consider this trial

Good fit: Ideal participants are native monolingual American English speakers aged 18–65 who pass the remote hearing screen, report no speech/language/neurological disorders, have no prior experience with dysarthria, and have access to a computer and headphones.

Not a fit: People who are non-native English speakers, outside the 18–65 age range, have hearing or speech-language disorders, or lack reliable internet or appropriate audio equipment are unlikely to benefit from participating.

Why it matters

Potential benefit: If successful, the results could help clinicians and communication partners tailor strategies to make speech from people with ALS easier to understand in everyday conversational settings.

How similar studies have performed: Previous perceptual studies have documented context and listener effects for dysarthric speech, but comparing interactive versus non-interactive contexts with a large remote sample is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* passing the remote hearing screening
* having no known speech, language or neurological disorders per self-report
* being a native monolingual speaker of American English
* having no experience communicating with people with dysarthria
* being between the ages of 18 and 65.

Exclusion Criteria:

* None - if volunteer meets the inclusion criteria, then they will be enrolled

Where this trial is running

University Park, Pennsylvania

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Amyotrophic Lateral Sclerosis
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.