Identifying factors related to weight loss in ALS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to establish a large Franco-German cohort to investigate the biological markers associated with weight loss in patients diagnosed with Amyotrophic Lateral Sclerosis (ALS). Participants will receive standard care for ALS while providing blood samples and completing questionnaires to gather data on clinical features, genetics, and metabolic status. The goal is to understand the mechanisms behind weight loss in ALS, which is critical for improving patient survival and quality of life. By identifying these markers, the study seeks to propose effective therapeutic strategies against weight loss in ALS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Incident cases included at the time of diagnosis with a definite, probable, probable laboratory-supported, or possible ALS according to El Escorial revised criteria and Gold Coast criteria for early diagnosis.
* Incident ALS cases identified and followed-up in the participant ALS \& Other Motor Neuron Diseases Referral Centres: seven in France and two in Germany.
* Patients who signed the informed consent form.
* Adults aged \>18 years old

Exclusion Criteria:

* Inability to understand the requirements of the protocol.
* Cognitive inability to sign and comprehend the informed consent form.
* Patients who will not accept Riluzole therapy during their follow-up.

Where it's running

• CHU de Lille
  Lille, France Recruiting
• Limoges University Hospital
  Limoges, France Recruiting
• Hôpital de la Timone
  Marseille, France Recruiting
• Hôpital Gui Chauliac
  Montpellier, France Recruiting
• CHU de Nice
  Nice, France Recruiting
• Hôpital de la Pitié Salpêtrière
  Paris, France Recruiting

Study contacts

• Principal investigator: Philippe COURATIER, Professor — University Hospital, Limoges
• Study coordinator: Philippe COURATIER, Pr
• Email: philippe.couratier@chu-limoges.fr
• Phone: 05 55 05 15 69

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.