Understanding the natural history and clinical features of ALS in China
A Study on the Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) in Mainland China
This study looks at how Amyotrophic Lateral Sclerosis (ALS) affects people in different parts of China and how the disease has changed over time to help improve diagnosis and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Sex | All |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT04454892 on ClinicalTrials.gov |
What this trial studies
This observational study aims to describe the distribution of Amyotrophic Lateral Sclerosis (ALS) across different regions and populations in mainland China, while exploring the changes in clinical features and prognosis over time. Researchers will compare data from ALS patients diagnosed between 1984-1998 and 1999-2004 to assess changes in survival rates and disease progression. The study seeks to provide insights into the etiology of ALS and improve understanding of its natural history, which is crucial for enhancing diagnosis and treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with ALS according to the revised El Escorial criteria.
Not a fit: Patients who decline to participate in follow-up or do not meet the diagnostic criteria for ALS will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of ALS, ultimately benefiting patients through better diagnostic and treatment approaches.
How similar studies have performed: Previous studies have shown varying success in understanding ALS through observational approaches, but this study aims to provide new insights with a large sample size in a specific geographic context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients were diagnosed with ALS recruited from all participant clinical centers.The diagnosis of ALS was made using the revised El Escorial criteria for definite, probable, lab-supported, and possible. Exclusion Criteria: * Decline to follow-up.
Where this trial is running
Beijing
- Peking University Third Hospital — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Dongsheng Fan, MD.PHD — Peking University Third Hospital
- Study coordinator: Lu Tang, Msc
- Email: tanglu@bjmu.edu.cn
- Phone: 13811854649
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.