Condition

Frontotemporal Dementia clinical trials and research

• 22Clinical trials
• 104NIH research projects
• 15Countries

Newest Frontotemporal Dementia clinical trials

All recruiting trials (22)

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• ARO-MAPT-SC in healthy adults and people with early Alzheimer's disease

  This trial will test whether ARO-MAPT-SC is safe, tolerable, and produces the expected drug levels and biomarker effects in healthy adults and people with early Alzheimer's disease.

  Recruiting at 4 sites Phase 1/2 Arrowhead Pharmaceuticals · East York, Ontario and 3 other locations · NCT07221344

• STELLA-FTD: Telehealth support program for family caregivers of frontotemporal degeneration

  This program will see if eight weekly live video group sessions help family caregivers of people with frontotemporal degeneration manage challenging behaviors and connect with community and peer resources.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT06613204

• Using vortioxetine to improve mood and cognition in patients with frontotemporal dementia

  This study is testing if a medication called vortioxetine can help improve mood and thinking skills in people with early-stage behavioral variant Frontotemporal Dementia.

  Recruiting Phase 2 Johns Hopkins University · Baltimore, Maryland · NCT06604520

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Comparing protein patterns in skin biopsies of neurodegenerative diseases

  This study is trying to see if the patterns of certain proteins in skin samples can help doctors better understand and diagnose different neurodegenerative diseases like Alzheimer's, Parkinson's, and frontotemporal dementia.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City · NCT06528964

• Advancing genomic medicine using electronic health records

  This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06377033

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Using Lemborexant to treat insomnia in patients with dementia

  This study is testing if a new sleep medication called lemborexant can help people with early-onset dementia sleep better without causing the usual side effects of other sleep aids.

  Recruiting Phase 4 Nova Scotia Health Authority · Halifax, Nova Scotia · NCT06093126

• Gene therapy for Frontotemporal Dementia with Progranulin Mutations

  This study is testing a one-time gene therapy to see if it can safely help people with Frontotemporal Dementia caused by a specific gene mutation by restoring a protein in the brain.

  Recruiting at 19 sites Phase 1/2 AviadoBio Ltd · Columbus, Ohio and 18 other locations · NCT06064890

• Genetic study of Frontotemporal Dementia in youth from affected families

  This study is trying to learn more about how Frontotemporal Dementia affects young people aged 9-17 who have family members with the condition by looking at their genes and doing various tests.

  Recruiting Western University · London, Ontario · NCT05779813

• Evaluating a new PET tracer for diagnosing dementia

  This study is testing a new imaging agent to see if it can help doctors diagnose Alzheimer's and frontotemporal dementia earlier by spotting changes in the brain.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT05374278

• Non-invasive brain stimulation for neurodegenerative diseases

  This study is testing if a new type of brain stimulation can help relieve symptoms in people with neurodegenerative diseases like Alzheimer's and dementia.

  Recruiting Kuopio University Hospital · Kuopio · NCT05326750

• Investigating Tanycytes in Alzheimer's Disease and Frontotemporal Dementia

  This study is trying to see how certain brain cells called tanycytes might be linked to hormone changes in people with Alzheimer's disease and frontotemporal dementia.

  Recruiting University Hospital, Lille · Lille · NCT05288842

• Collection of cerebrospinal fluid for cognitive disorder research

  This study is collecting spinal fluid from people with cognitive disorders like Alzheimer's and dementia to help improve how these diseases are diagnosed.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT04844060

• Genetic study on Frontotemporal Dementia in Lille

  This study is trying to learn more about genetic Frontotemporal Dementia by looking at both people with symptoms and those at risk, to find better ways to track the disease and treat it in the future.

  Recruiting University Hospital, Lille · Lille · NCT04639622

• Online cognitive assessment for monitoring brain health

  This study is testing an online brain health test for people aged 50 and older to see if it can help track their thinking skills and identify any issues early on.

  Recruiting Alzheimer's Light LLC · Miami, Florida · NCT04114994

• Evaluating retinal imaging for neurodegenerative diseases

  This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.

  Recruiting Duke University · Durham, North Carolina · NCT03233646

• Understanding neurodegenerative disorders like ALS and frontotemporal dementia

  This study is trying to see if adults with neurodegenerative disorders like ALS and frontotemporal dementia can join future research by checking their health and collecting samples for further testing.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03225144

• Imaging neuroinflammation in frontotemporal dementia

  This study is testing a new imaging technique to see how inflammation in the brain affects people with frontotemporal dementia and how it varies among different types of the condition.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT02945774

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

• Understanding Inclusion Body Myopathy, Paget's Disease, and Frontotemporal Dementia

  This study is trying to learn more about how changes in the VCP gene affect people with inherited muscle, bone, and brain conditions, by collecting health information and samples from families who have these issues.

  Recruiting University of California, Irvine · Irvine, California · NCT01353430

NIH-funded research (newest 40 of 104)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.

  This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-9980670

• Exploring how oxidative stress and ferroptosis affect frontotemporal dementia

  A study using human iPSC-derived neurons from people with frontotemporal dementia to see how reactive oxygen species and a cell death process called ferroptosis relate to disease features.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11606577

• Automated language analysis for Alzheimer’s disease and frontotemporal dementia in Latino and English speakers

  A low-cost, automated speech and language analysis tool is being developed to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553470

• Automated language analysis for Alzheimer’s and frontotemporal dementia across Latino and English-speaking groups

  A low-cost, automated language study aims to help diagnose and understand Alzheimer’s and FTD in diverse Spanish- and English-speaking communities.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553469

• Automated language analysis to help diagnose Alzheimer’s and frontotemporal dementia in Latino and English speakers

  A low-cost, computer-based method analyzes speech and language to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553467

• Automated language analysis for Alzheimer's and frontotemporal dementia in Latino and English-speaking communities

  A low-cost, computer-based language analysis method is being developed to help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking people.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553466

• Automated language analysis to detect Alzheimer’s and frontotemporal dementia in Latino and English-speaking adults

  A low-cost, computer-based language and speech analysis tool will help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553465

• Frontotemporal Dementia: Genes, Images, and Emotions (patient-oriented overview)

  A long-term research program at UC San Francisco aims to understand how genetic and brain-image findings relate to the emotions and daily life of people affected by frontotemporal dementia and to develop better ways to track and diagnose the disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11523159

• Frontotemporal Dementia: Genes, Images, and Emotions

  A multi-project effort to understand and monitor frontotemporal dementia and related Alzheimer’s conditions through genetics, brain imaging, and emotional studies, with steps toward new biomarkers and better patient care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11523158

• Synaptopathy and CYLD in Frontotemporal Dementia (FTD)

  A new NIH-funded project will look at how CYLD gene changes contribute to synapse problems in people with frontotemporal dementia.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11463227

• Axon-guidance genes and ALS/FTD: how neuron paths go wrong

  A short-term NIH grant will explore how axon guidance genes contribute to ALS and frontotemporal dementia in people and neuronal cells.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11458497

• Sleep and body clock disruption in bvFTD patients

  A research team at Vanderbilt will study how sleep problems relate to brain changes and symptoms in adults with behavioral variant frontotemporal dementia.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11450715

• C9orf72 ALS/FTD Prevent: prepping for future treatment

  This grant aims to get ready for a preventive treatment for people who carry the C9orf72 genetic change that can lead to ALS or frontotemporal dementia.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11431628

• Automated language analysis for Alzheimer’s disease and frontotemporal dementia in Latino and English speakers

  A machine learning approach analyzes speech and language from Latino and English-speaking people to help detect Alzheimer’s disease and related dementias.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11408631

• Automated speech and language detection for Alzheimer’s and frontotemporal dementia in Spanish and English speakers

  This project uses automated speech and language analysis to help spot signs of Alzheimer’s disease and frontotemporal dementia in Spanish- and English-speaking people, with special focus on Latino communities.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404660

• Automated speech and language checks for Alzheimer’s and frontotemporal dementia in English and Spanish speakers

  This project uses computer analysis of natural speech to find early signs of Alzheimer’s disease or frontotemporal dementia in English- and Spanish-speaking adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404659

• Automated speech and language tests for Alzheimer's and frontotemporal dementia in Latino and English speakers

  This project uses automated speech and language analysis with machine learning to spot language changes linked to Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking people.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404658

• Speech and language tools to detect Alzheimer's and frontotemporal dementia in Spanish and English speakers

  Using short natural speech recordings, researchers will look for sound and language patterns that can help detect Alzheimer's disease and frontotemporal dementia in Spanish-speaking Latinos and English-speaking adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404657

• Speech and language screening for Alzheimer's and frontotemporal dementia in Latino and English-speaking adults

  This project uses automated speech and language analysis to find signs of Alzheimer's disease and frontotemporal dementia in Latino and English-speaking adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404656

• Using speech and language analysis to spot Alzheimer’s disease and frontotemporal dementia in English- and Spanish-speakers

  This project uses automated speech and language tools to help find signs of Alzheimer’s disease and frontotemporal dementia in English- and Spanish-speaking adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11404655

• Understanding how a genetic repeat causes harmful protein production in ALS/FTD

  Aimed at uncovering how a genetic repeat in the C9orf72 gene triggers abnormal protein production that damages nerve cells in ALS and FTD.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11384771

• CHCHD10 and its role in dementia and ALS

  Researchers are studying how mutations in CHCHD10 may cause brain diseases like frontotemporal dementia and ALS, with the goal of uncovering how the protein misfolds and forms damaging structures.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11380813

• Genetic analysis of UBQLN2-related neurodegenerative disease in ALS/FTD

  Researchers are studying how UBQLN2 gene changes contribute to ALS and frontotemporal dementia to better understand why these diseases develop.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11376726

• Understanding social attachment changes in frontotemporal dementia (FTD)

  Researchers are studying how aging and dementia affect social bonds and empathy, with a focus on a gene-related form of FTD using animal models to uncover how social attachment works in the brain.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11368482

• C9orf72-related brain changes in frontotemporal dementia and ALS

  This NIH grant funds research to understand how a genetic change in C9orf72 affects brain regions in frontotemporal dementia and ALS, with the goal of identifying clues that could help patients in the future.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11367328

• Deciphering RNA-Related Blood-Brain Barrier Breakdown in C9orf72-Linked Frontotemporal Dementia

  A patient-focused look at how harmful RNA buildup in a gene linked to frontotemporal dementia may weaken the brain’s protective barrier and what that could mean for future therapies.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11335687

• How a C9orf72 repeat makes toxic proteins in ALS and frontotemporal dementia

  Researchers are figuring out how a repeated DNA segment in the C9orf72 gene leads cells to make harmful repeat proteins that can contribute to ALS and frontotemporal dementia.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11333790

• Frontotemporal Dementia: Genes, Images, and Emotions

  A large NIH grant supports a multi-project program to better understand frontotemporal dementia and move toward new tests and therapies for people affected by FTD and related Alzheimer’s-type conditions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11325867

• Why people with frontotemporal dementia lose empathy

  This work looks at whether problems in a brain area called the dorsomedial prefrontal cortex cause people with behavioral frontotemporal dementia to lose empathy.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11323502

• Remote smartphone tests for inherited frontotemporal dementia

  Smartphone tasks will be used to find early changes and monitor symptoms in people who carry inherited frontotemporal dementia mutations and in adults across the lifespan.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11310847

• How C9ORF72 changes lead to frontotemporal dementia and ALS

  Researchers are using fruit flies and nerve cells made from patient samples to find genes that make C9ORF72-linked frontotemporal dementia or ALS better or worse.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11307657

• T cells and the gut microbiome in inherited frontotemporal dementia

  This project looks at whether shifting immune T cells and gut microbiome signals can help people with inherited frontotemporal dementia linked to C9ORF72 mutations.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11306600

• Antisocial behaviors in frontotemporal dementia: aggression versus rule‑breaking

  This project looks at different kinds of antisocial behaviors—like aggression or rule‑breaking—in people with behavioral variant frontotemporal dementia (bvFTD) and how those behaviors relate to brain changes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11306098

• Emotional and social changes in early frontotemporal dementia

  The team will use wearable sensors and short remote tasks to track emotional reactions and social behavior in people with early or genetic frontotemporal dementia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11303362

• How inherited FTD and Alzheimer's genes affect children's brain development

  Researchers are looking at whether children who carry inherited genes for frontotemporal dementia or Alzheimer's show early differences in brain structure and behavior compared with their noncarrying family members and kids with autism, ADHD, or learning disabilities.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11299051

• Understanding progranulin's role in brain cell recycling and dementia

  The team is looking at whether losing the protein progranulin causes problems in cells' waste‑clearing system that may lead to Alzheimer's disease and frontotemporal dementia.

  NIH research Emory University · Atlanta, United States · NIH-11297631

• Shared disease pathways in nerve cells from people with frontotemporal dementia

  This project uses nerve cells made from people with frontotemporal dementia to find common ways the cells break down that might point to new treatments.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11296109

• Deep profiling of people at risk for frontotemporal dementia in India

  This project follows families with a history of frontotemporal dementia in India to find early signs and genetic risk factors before symptoms appear.

  NIH research National Institute of Mental Health and Neurosciences (Nimhans) · Bangalore, INDIA · NIH-11284387

• Early signs of frontotemporal dementia in rhesus monkeys with a MAPT mutation

  Researchers are following rhesus monkeys that carry the human MAPT R406W mutation to find early brain and behavior changes that could guide prevention for people at risk of frontotemporal dementia.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11284047

• How C9orf72 genetic changes lead to frontotemporal dementia

  Researchers use worm and mammal models to find why a C9orf72 genetic repeat causes brain cell damage in people with frontotemporal dementia.

  NIH research Northwestern University · Chicago, United States · NIH-11263618

Related topics

Quick answers

How many Frontotemporal Dementia clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (11 trials), Canada (6 trials), France (3 trials), Mexico (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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