Condition

Critically Ill clinical trials and research

• 12Clinical trials
• 57NIH research projects
• 12Countries

Newest Critically Ill clinical trials

All recruiting trials (12)

• Transducer levelling errors in everyday ICU practice

  In critically ill, vasopressor-treated adults with arterial and central venous lines, this study tests how small height differences in pressure transducers may lead to measurement errors that could affect treatment decisions.

  Recruiting Vastra Gotaland Region · Gothenburg and 1 other locations · NCT07330505

• What predicts death in the ICU? Analyzing APACHE II in Colombian patients

  This study tests how well the APACHE II score predicts ICU mortality in adults treated at a Colombian hospital.

  Recruiting Hospital Departamental de Villavicencio · Villavicencio, Meta Department · NCT07249749

• Using parasternal intercostal muscle thickening to help decide when to stop mechanical ventilation

  This trial will test whether adding a bedside ultrasound measurement of parasternal intercostal muscle thickening helps doctors decide when to take critically ill patients off mechanical ventilation to reduce reintubation.

  Recruiting Cairo University · Cairo, Giza Governorate · NCT07143695

• Testing SGLT2 inhibitors for treating sepsis in adults

  This study is testing if a new type of diabetes medication can help adults with sepsis recover better and feel safer.

  Recruiting at 2 sites Hospital Authority, Hong Kong · Hong Kong, Hong Kong and 2 other locations · NCT06473844

• Analgesia Nociception Index monitoring of the autonomic nervous system during continuous renal replacement therapy

  We will try using the Analgesia Nociception Index to see if changes in autonomic signals match blood pressure and heart responses when fluid is removed during continuous renal replacement therapy in critically ill adults.

  Recruiting Hospices Civils de Lyon · Bron · NCT06285162

• Using remote ischemic preconditioning to prevent kidney injury in septic patients

  This study is testing if a special technique that temporarily restricts blood flow in the arm can help prevent kidney injury in critically ill patients with sepsis.

  Recruiting Universität Münster · Münster · NCT05830669

• Investigating infections in critically ill patients on continuous renal replacement therapy

  This study looks at critically ill patients on a special kidney treatment to see how often they get new infections and what might cause them.

  Recruiting at 5 sites University Hospital Muenster · Innsbruck and 4 other locations · NCT05450185

• Monitoring oxygen levels during intubation in critically ill patients

  This study is testing if monitoring oxygen levels in two places during intubation can help critically ill patients in the ICU get better preoxygenation than the usual methods.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT05409573

• Observational study on drug use in critically ill children

  This study looks at how different medications work in critically ill children in the Pediatric Cardiac Intensive Care Unit to better understand their effects and safety.

  Recruiting Duke University · Durham, North Carolina · NCT05055830

• Heterogeneity of Critical Illness in ICU Patients

  This study tests how patient characteristics relate to the severity of organ failure in adults admitted to the ICU with critical illness.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT04502511

• Registry of patients needing ECMO in Australia and New Zealand

  This study is creating a detailed database of patients in Australia and New Zealand who need ECMO for serious heart or lung problems to help improve treatment and outcomes for critically ill patients.

  Recruiting at 28 sites Australian and New Zealand Intensive Care Research Centre · Canberra, Australian Capital Territory and 28 other locations · NCT03793257

• Examining Monocyte Profiles in Critically Ill Patients with Pseudomonas Aeruginosa Sepsis

  This study is trying to see if the type of immune cells in the blood of critically ill patients with sepsis from Pseudomonas aeruginosa can tell us more about how sick they are and how they might recover.

  Recruiting University of Ulm · Ulm · NCT03044223

NIH-funded research (newest 40 of 57)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Personalized oxygen therapy for critically ill adults

  A study tests whether customizing oxygen levels for adults on invasive ventilation can lower death rates and complications.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11579981

• Imaging and EHR data combine to predict ICU outcomes with clinician and patient input

  Aims to build a computer model that uses chest X-ray images, doctor notes, and electronic health record data to predict outcomes for ICU patients, with input from clinicians, patients’ families, and ethics experts.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11538923

• Teleconsultation to Improve Safety for Critically Ill Infants and Children Before hospital arrival

  A national study tests whether remote pediatric expert advice during ambulance transport reduces harm to critically ill babies and kids.

  NIH research Boston Medical Center · Boston, United States · NIH-11531877

• Patient-ventilator Asynchrony in Critically Ill Children

  This grant explores how often and why mechanically ventilated children have mismatches between their own breathing efforts and the ventilator, with the goal of making ventilation safer and more comfortable for kids.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11529199

• Patient-ventilator asynchrony in critically ill children

  A study to understand when ventilators don’t perfectly match a child’s breathing needs and how this affects recovery.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11529197

• BrighT STAR SIRIUS: a toolkit to cut unnecessary blood cultures in sick kids

  A multi-site study is testing a toolkit to reduce unnecessary blood culture tests in critically ill children to prevent unnecessary treatments and harms.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11452997

• Empowering Parents of Critically Ill Children with a quick, family-focused support program

  A short, friendly program helps parents of kids in the PICU feel less stressed and anxious by using a brief, flexible cognitive-behavioral approach.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11448796

• Personalized treatment recommendations for critically ill patients using causal machine learning

  Aims to tailor treatments for critically ill adults by using advanced machine learning to predict who will benefit or be harmed by a given therapy.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11447094

• Personalized fever measure to detect infection in older ICU patients

  A study tests whether using a patient’s own temperature history is better at spotting infections in older adults in the ICU than a fixed fever threshold.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11441427

• Time-limited trials to guide care for seriously ill patients in the ICU

  A real-world study tests using structured, time-limited conversations and agreed-upon treatment plans to help seriously ill patients and their families avoid non-beneficial ICU care.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11423659

• Reestablishing sleep and clock alignment in critically ill patients with a sleep–clock bundle

  A study tests a sleep and circadian rhythm bundle in ICU patients to help restore healthy sleep patterns and bodily rhythms.

  NIH research Yale University · New Haven, United States · NIH-11420590

• Personalized Kidney Support in Critical Illness (PACKS-ICU)

  An AI-powered tool helps doctors predict who needs dialysis in the ICU to improve outcomes for people with acute kidney injury.

  NIH research Daecos LLC · La Jolla, United States · NIH-11409014

• Tracheobronchitis in people recovering after critical illness with a tracheostomy

  This grant studies tracheobronchitis that can happen in people recovering from critical illness after a tracheostomy, aiming to understand how often it occurs and what factors influence outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11406098

• Interrupting harmful lung cell interactions to reduce fluid leakage in critically ill children with bronchiolitis

  AYA pediatric patients with bronchiolitis who are severely ill may benefit from a study that targets lung cell signals to lessen fluid leak and improve breathing.

  NIH research Yale University · New Haven, United States · NIH-11401847

• Teleconsultation to improve safety for critically ill infants and children before hospital care

  A telehealth approach connects pediatric experts to EMS teams during prehospital care to reduce harm to very young patients.

  NIH research Boston Medical Center · Boston, United States · NIH-11392263

• BRIDGE: A gentle tool to help families of critically ill kids talk with doctors

  A 3-site study is testing BRIDGE, a brief tool to help parents of very young children in the ICU make decisions together with their health care team.

  NIH research Duke University · Durham, United States · NIH-11378015

• A tool to help families of ICU patients stay calm and make better decisions

  A brief, tablet-based program helps surrogate decision-makers in the ICU manage emotions and make clearer treatment choices.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11345828

• Optimizing ICU rehabilitation for critically ill adults

  A program is being tested to find the best dose and timing of rehab for adults in the ICU on breathing machines to help them recover faster.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11339259

• VoiceLove: A patient-facing app to reduce ICU delirium and boost family engagement for people with Alzheimer's and related dementias

  A patient-facing app helps families and ICU teams work together to prevent delirium in people with Alzheimer’s and related dementias.

  NIH research Voicelove INC. · Scarsdale, United States · NIH-11330598

• Patient-ventilator mismatch in critically ill children

  This grant explores how children on ventilators sometimes fight against the machine, and aims to make ventilation more synchronized and safer.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11324955

• Fewer breathing-tube tests to prevent unnecessary antibiotic use in critically ill children

  This project aims to reduce unneeded breathing-tube cultures so fewer critically ill children get antibiotics they may not need.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11281263

• An app to improve communication and family engagement for critically ill patients with delirium

  This study is testing a new app called VoiceLove that helps families communicate better with healthcare providers about loved ones in the ICU, especially those with Alzheimer's and related dementias, to reduce confusion and improve their care.

  NIH research Voicelove LLC · Scarsdale, United States · NIH-11222806

• Effects of hourly neurological checks on older patients with brain injuries

  This study is looking at how often doctors check on the brain health of older adults who are very sick in the ICU after a brain injury, to see how it affects their sleep and thinking skills, with the goal of improving their care.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11203855

• Restoring sleep and body‑clock timing for ICU patients

  This trial will try a combined sleep-and-circadian care program to help people in the intensive care unit sleep better and keep their internal clock on track.

  NIH research Yale University · New Haven, United States · NIH-11176008

• Tracheobronchitis in people with tracheostomies recovering from critical illness

  This project follows people with tracheostomies during recovery from critical illness to learn how and why tracheobronchitis happens and how it affects recovery.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11171389

• Enoxaparin to prevent catheter-related blood clots in critically ill children by age

  This project looks at whether the blood thinner enoxaparin prevents catheter-related blood clots in critically ill babies and children and whether it works differently for infants under 1 year compared with older kids.

  NIH research Yale University · New Haven, United States · NIH-11163431

• Resistant gut bacteria and infections in people who are very sick or immunocompromised

  This program looks at how antibiotic‑resistant gut bacteria like VRE, ESBL/CRE, and C. difficile grow and cause infections in people who are critically ill or have weakened immune systems.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11159469

• Biorepository to identify immune types in critically ill COVID-19 patients

  Collecting and analyzing blood and lower-lung samples from critically ill COVID-19 patients to find immune and microbial patterns linked to worse outcomes.

  NIH research New York University School of Medicine · New York, United States · NIH-11159396

• Live video consults to make ambulance care safer for critically ill babies and children

  This project sees whether live video calls with pediatric experts can make ambulance care safer for critically ill infants and young children.

  NIH research Boston Medical Center · Boston, United States · NIH-11146685

• Creating a support program for parents of critically ill children in the PICU

  This study is testing a new program called EMPOWER to help parents of kids in the pediatric intensive care unit feel better and more confident during this tough time, so they can better support their child's recovery and take care of their own mental health.

  NIH research Central Michigan University · Mount Pleasant, United States · NIH-11109405

• Investigating factors that lead to Candida colonization in critically ill patients

  This study is looking at how certain traits of both patients and the Candida fungus can affect the chances of getting a gut infection in critically ill patients in the ICU, with the goal of finding ways to prevent serious infections.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11096085

• Improving mobility for critically ill children in the PICU

  This study is testing a new program called 'PICU Up!' to help critically ill children move around more in the pediatric intensive care unit, which can help them recover better and feel stronger, and it involves families in the process to make it easier for everyone.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11094003

• Understanding the immune response in critically ill COVID-19 patients

  This study is looking at patients with severe COVID-19 to find out how their immune systems respond to the virus, which could help create better treatments tailored just for them.

  NIH research New York University School of Medicine · New York, United States · NIH-11093654

• Personalized medication dosing for critically ill children

  This study is working to make sure that critically ill children get the right amount of medicine by using smart computer models that take into account how each child's body processes drugs, especially those with kidney problems, so they can receive safer and more effective treatments.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11089510

• Understanding how ventilators interact with critically ill children

  This study is looking at how well ventilators work for critically ill children who need help breathing, focusing on finding out which breathing mismatches can be most harmful, so we can improve their care and recovery.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11082244

• Improving antibiotic use in critically ill children with respiratory infections

  This study is looking at ways to help doctors give fewer unnecessary antibiotics to critically ill children on ventilators by improving how they test for infections, so kids can get the right treatment without the risks of overusing antibiotics.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11046525

• How the timing of delivery affects breastfeeding success in mothers of critically ill infants

  This study is looking at how the age at which babies are born affects how well mothers can produce breast milk, especially for those who need to pump, and it aims to help support moms in making enough milk for their little ones in the NICU.

  NIH research University of Florida · Gainesville, United States · NIH-11032891

• Improving drug dosing for critically ill infants with heart disease

  This study is looking to find the best way to give heart medicine to critically ill babies, especially those with heart problems, so that it works better and is safer for them.

  NIH research Duke University · Durham, United States · NIH-11032773

• Helping family caregivers of critically ill patients make better decisions

  This study is all about helping family caregivers of critically ill patients in ICUs, especially those from Black, Indigenous, and People of Color communities, by offering support to ease their emotional stress and help them make tough end-of-life decisions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11019746

• Understanding why critically ill patients with respiratory failure and sepsis face health disparities.

  This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11018640

Related topics

Quick answers

How many Critically Ill clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in Germany (3 trials), France (2 trials), Netherlands (1 trial), Egypt (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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