Examining the link between esophageal pressure and respiratory support failure in patients with acute respiratory failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between trans esophageal pressure and respiratory mechanics, such as nasal pressure, in patients experiencing acute hypoxic respiratory failure. The focus is on understanding how these measurements correlate with the failure of non-invasive respiratory support methods. The study includes patients with various underlying causes of respiratory failure, including those affected by COVID-19. By analyzing these correlations, the research aims to improve patient management in acute respiratory conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years
* Acute hypoxic respiratory failure (P/F \< 200)

Exclusion Criteria:

* Acute pulmonary edema
* Chest wall deformities
* Immediate need for Mechanical Ventilation
* Pregnancy
* Hypercapnic RF

Where it's running

• University Hospital of Modena Policlinico
  Modena, Italy Recruiting

Study contacts

• Study coordinator: Alessandro Marchioni, MD, PhD
• Email: marchioni.alessandro@unimore.it
• Phone: 00390594225859

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

  This pediatric pilot tests whether a carefully dosed saline bolus with electrical impedance tomography can map lung perfusion and ventilation distribution in kids with acute respiratory failure.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07532811

• Predicting HFNO failure within 72 hours using a physiology-informed model at 30 minutes

  This study tests a model that uses Heart–lung physiology and 30-minute data to see if high-flow nasal oxygen will fail in adults with acute hypoxemic respiratory failure.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07366541

• Bedside ultrasound of the IVC to find pulmonary edema in adults with sudden severe breathlessness

  This project will test whether bedside ultrasound measurements of how the inferior vena cava changes with breathing can help identify pulmonary edema in adults who come to the emergency department with sudden breathing failure.

  Recruiting Università degli Studi del Piemonte Orientale Amedeo Avogadro · Novara · NCT07324980

• Brain–lung interaction during sudden severe low-oxygen respiratory failure

  We will try EEG, NIRS, and neck muscle recordings before and one hour after starting high-flow nasal oxygen in adults with sudden low-oxygen respiratory failure to see how the brain and lungs interact.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07279831

• Comparing SpO2 targets and oximeters during high-flow nasal oxygen

  This study tests whether two different pulse oximeters (Nonin and Philips) and two SpO2 targets (90% vs 94%) change the amount of oxygen (FiO2) set for adults in the ICU receiving high-flow nasal oxygen.

  Recruiting Laval University · Québec, Quebec · NCT07168213

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.