Examining the link between esophageal pressure and respiratory support failure in patients with acute respiratory failure
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure
This study looks at how pressure in the esophagus relates to breathing support problems in patients with severe breathing issues, including those with COVID-19, to find better ways to help them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Modena and Reggio Emilia Academic / other |
| Locations | 1 site (Modena) |
| Trial ID | NCT03826797 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between trans esophageal pressure and respiratory mechanics, such as nasal pressure, in patients experiencing acute hypoxic respiratory failure. The focus is on understanding how these measurements correlate with the failure of non-invasive respiratory support methods. The study includes patients with various underlying causes of respiratory failure, including those affected by COVID-19. By analyzing these correlations, the research aims to improve patient management in acute respiratory conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are experiencing acute hypoxic respiratory failure.
Not a fit: Patients with acute pulmonary edema, chest wall deformities, an immediate need for mechanical ventilation, pregnancy, or hypercapnic respiratory failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of respiratory mechanics and improve the effectiveness of non-invasive ventilation strategies for patients with acute respiratory failure.
How similar studies have performed: While this study explores a specific correlation, similar studies have shown promise in understanding respiratory mechanics and improving non-invasive ventilation outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>18 years * Acute hypoxic respiratory failure (P/F \< 200) Exclusion Criteria: * Acute pulmonary edema * Chest wall deformities * Immediate need for Mechanical Ventilation * Pregnancy * Hypercapnic RF
Where this trial is running
Modena
- University Hospital of Modena Policlinico — Modena, Italy (Recruiting)
Study contacts
- Study coordinator: Alessandro Marchioni, MD, PhD
- Email: marchioni.alessandro@unimore.it
- Phone: 00390594225859
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.