Comparing SpO2 targets and oximeters during high-flow nasal oxygen

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares two commercial pulse oximeters (Nonin and Philips) and two SpO2 targets (90% and 94%) to see how they affect the fraction of inspired oxygen (FiO2) set during high-flow nasal oxygen therapy. Each enrolled patient undergoes four randomized 10-minute periods covering every oximeter-target combination while clinicians manually titrate FiO2 to the displayed SpO2. Arterial blood gas is collected at the end of each period to measure actual oxygenation. The study is conducted in adult ICU patients who already have an arterial catheter and are receiving high-flow nasal oxygen.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years of age
* Admiitted in intensive care unit
* Presence of an arterial catheter
* Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .

Exclusion Criteria:

* No SpO2 signal with oximeter in use
* False nails or nail polish
* Methemoglobinemia \>0.015 on last available arterial gas
* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)
* Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)

Where it's running

• Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
  Québec, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Francois Lellouche Principal Investigator
• Email: francois.lellouche@criucpq.ulaval.ca
• Phone: 418-656-8711

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• High Flow Tracheal Oxygen to Help Wean Tracheostomy Patients from Ventilation

  This trial tests whether delivering high-flow oxygen directly through the trachea helps tracheostomized patients on mechanical ventilation try to come off ventilation faster than standard tracheal mask therapy.

  Recruiting King Faisal Specialist Hospital & Research Center · Riyadh · NCT07559591

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

  This pediatric pilot tests whether a carefully dosed saline bolus with electrical impedance tomography can map lung perfusion and ventilation distribution in kids with acute respiratory failure.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07532811

• Predicting HFNO failure within 72 hours using a physiology-informed model at 30 minutes

  This study tests a model that uses Heart–lung physiology and 30-minute data to see if high-flow nasal oxygen will fail in adults with acute hypoxemic respiratory failure.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07366541

• Bedside ultrasound of the IVC to find pulmonary edema in adults with sudden severe breathlessness

  This project will test whether bedside ultrasound measurements of how the inferior vena cava changes with breathing can help identify pulmonary edema in adults who come to the emergency department with sudden breathing failure.

  Recruiting Università degli Studi del Piemonte Orientale Amedeo Avogadro · Novara · NCT07324980

• Brain–lung interaction during sudden severe low-oxygen respiratory failure

  We will try EEG, NIRS, and neck muscle recordings before and one hour after starting high-flow nasal oxygen in adults with sudden low-oxygen respiratory failure to see how the brain and lungs interact.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07279831

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.