CPAP support for acute low-oxygen respiratory failure in Burkina Faso

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults presenting with acute hypoxemic respiratory failure in the emergency departments of four university hospitals in Burkina Faso will receive Boussignac‑type CPAP as a non‑invasive respiratory support. The primary outcome is whether CPAP reduces the occurrence of intubation criteria within seven days. Secondary outcomes include 28‑day mortality, oxygenation measured by SpO2/FiO2, hospital length of stay, and safety events. Ancillary analyses will examine the role of ultrasound, determine etiologies and prognosis of ARF and ARDS, and estimate the cost of care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All patients aged 18 years and older will be included in the study if they meet at least one of the following criteria :

* Acute respiratory distress, defined as dyspnea respiratory rate ≥ 25 cycles/min
* Hypoxemia, defined as the need for more 6 liters of oxygen to maintain an oxygen saturation (SpO2) of ≥ 92%. The fraction of inspired oxygen (FiO2) will be estimated using the 3% rule.

Exclusion Criteria:

Patients with any of the following criteria will not be included in the study:

* Pregnant or breastfeeding women
* Persons deprived of their liberty
* Exacerbation of asthma, chronic obstructive pulmonary disease, or another chronic respiratory disease
* Moderate to large amount of unilateral or bilateral undrained pleural effusion
* Contraindication to CPAP: patient refusal, undrained pneumothorax, chest injury, repeated or large vomiting, upper gastrointestinal bleeding, craniofacial trauma, severe upper airway obstruction, or tetraplegia in the initial phase
* Cardiac arrest, severe arrhythmias, shock requiring the use of vasopressors (norepinephrine, adrenaline, dopamine)
* Altered level of consciousness (Glasgow Coma Scale score \< 13), repeated seizures, or status epilepticus
* Medical decision to limit treatment: no intubation, no admission to intensive care
* Refusal to participate in the study or participation in another interventional study on respiratory distress or acute respiratory failure.

Where it's running

• Centre Hospitalier Universitaire Souro Sanou
  Bobo-Dioulasso, Houet, Burkina Faso Recruiting
• CHU Yalgado Ouedraogo
  Ouagadougou, Kadiogo, Burkina Faso Not yet recruiting
• CHU Tengandogo
  Ouagadougou, Kadiogo, Burkina Faso Not yet recruiting
• CHU Bogodogo
  Ouagadougou, Kadiogo, Burkina Faso Not yet recruiting

Study contacts

• Principal investigator: Ismael Guibla, doctor — University Hospital Souro Sanou, Burkina Faso
• Study coordinator: Ismael Guibla, doctor
• Email: ismaelguibla@gmail.com
• Phone: +22676135113

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.