Condition

Thyroid Cancer clinical trials and research

• 80Clinical trials
• 35NIH research projects
• 1New in 30 days
• 25Countries

Newest Thyroid Cancer clinical trials

All recruiting trials (80)

• MRG003 added to ongoing treatment after progression in EGFR-positive advanced thyroid cancer

  In this study, researchers test whether adding MRG003 to a patient’s current thyroid cancer treatment can shrink tumors for those whose cancer initially responded but later progressed.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07874321

• Selective coverage radiotherapy vs. full coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer

  This trial tests whether covering only the tumor-affected area with radiation is as effective as full-area coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer, while aiming to reduce side effects and improve quality of life.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07777536

• Trop-2 Targeted PET/CT for Recurrent and Metastatic Thyroid Cancer

  This study tests whether a Trop-2 targeted PET/CT scan can better detect recurrent or metastatic thyroid cancer in adults than another PET/CT scan (FAPI).

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT07753499

• WeChat-supported neck exercises after thyroidectomy

  A telehealth program using a WeChat mini program tests if guided neck exercises after thyroid surgery help early recovery and quality of life.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT07707401

• Pralsetinib Drug Interaction Study in RET Fusion/MUTATION Positive Solid Tumors

  This trial tests whether pralsetinib changes how the body processes certain medicines in adults with RET fusion- or mutation-positive advanced solid tumors.

  Recruiting at 2 sites Phase 4 Rigel Pharmaceuticals · Logroño, La Rioja and 1 other locations · NCT07704658

• AI chatbot to guide thyroid cancer patients through perioperative education

  A new AI chatbot is being tested to see if it helps thyroid cancer patients better prepare for discharge, recover well, and stay engaged in their care compared with traditional education.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07634978

• Bilateral neck block during thyroid surgery to see if stress markers change

  Researchers will test whether adding a bilateral intermediate cervical plexus block to the anesthesia during total thyroidectomy helps reduce the surgical stress response in adults.

  Recruiting Phase 4 University Hospital Dubrava · Zagreb, City of Zagreb · NCT07600580

• Safety and dosing of 177Lu-INN805 in patients with malignant solid tumors

  This early-phase, single-arm study tests different dose levels of 177Lu-INN805 to see if it can be safely given and if it shows signs of activity in adults with hard-to-treat solid tumors.

  Recruiting Early Phase 1 FindCure Biosciences (ZhongShan) Co., Ltd. · Wuxi, Jiangsu · NCT07459283

• 177Lu-CTR-FAPI for thyroid cancer

  This will try a radioactive drug called 177Lu-CTR-FAPI in people with progressive, radioactive iodine–refractory thyroid cancer to see if it is safe and helps shrink tumors.

  Recruiting at 2 sites Phase 1 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing and 1 other locations · NCT07438847

• F-18 Tetrafluoroborate PET/CT to find recurrent or residual differentiated thyroid cancer

  This test will see if F-18 Tetrafluoroborate PET/CT finds recurrent or residual differentiated thyroid cancer better than standard F-18 FDG PET/CT in adults who had surgery and radioactive iodine and now have rising thyroglobulin or anti-thyroglobulin.

  Recruiting at 2 sites Ankara University · Ankara, Ankara and 1 other locations · NCT07436455

• Carbon nanoparticle‑loaded iron for advanced solid tumors

  This test uses direct injections of a carbon nanoparticle‑loaded iron medicine (CNSI‑Fe) to see if it can shrink tumors in adults with advanced solid cancers who have no effective standard treatment options.

  Recruiting at 4 sites Phase 1/2 Sichuan Enray Pharmaceutical Sciences Company · Beijing, Beijing Municipality and 8 other locations · NCT07433283

• Low calcium after thyroid removal

  This project will see if clinical, lab, and surgical factors predict low calcium after thyroid surgery in adults treated at Minia University Hospital from 2014–2024.

  Recruiting Minia University · Minya, Minya Governorate · NCT07428057

• Neoadjuvant treatment response in locally advanced thyroid cancer

  This study will test whether neoadjuvant therapies can safely shrink locally advanced thyroid cancers and improve surgical outcomes for patients who then undergo thyroidectomy.

  Recruiting Fujian Medical University · Fuzhou, Fujian · NCT07419932

• How changing thyroid hormone levels affects blood sugar, lipids, and energy use

  This trial will test whether raising or lowering thyroid hormones in people with newly diagnosed Graves' disease or thyroid cancer changes blood sugar, insulin, and lipid metabolism using oral glucose tolerance tests.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT07410637

• Navigation program for young cancer survivors

  This project tests an adapted navigation program to help adolescent and young adult cancer survivors get timely care within Kaiser Permanente Southern California.

  Recruiting Kaiser Permanente · Pasadena, California · NCT07406087

• How medicines are managed during targeted radioligand cancer treatment

  This project tracks how pharmacists and nuclear medicine teams manage medications and provide pharmaceutical advice for adults receiving targeted radioligand treatments like Lutathera and Pluvicto.

  Recruiting Hospices Civils de Lyon · Bron and 2 other locations · NCT07389512

• Active monitoring for small Bethesda IV thyroid nodules

  This program will try active monitoring with scheduled ultrasounds and clinic visits instead of immediate surgery for adults with a single Bethesda IV thyroid nodule under 2 cm.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07370675

• MRG003 plus pucotenlimab for EGFR-positive advanced anaplastic or poorly differentiated thyroid cancer

  This trial will see if combining MRG003 and pucotenlimab can help adults with EGFR-positive unresectable or metastatic anaplastic or poorly differentiated thyroid cancer by shrinking tumors or slowing their growth.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07235566

• Meaning-Centered Therapy for Latinos for adults with advanced cancer

  This study tests whether Meaning-Centered Psychotherapy for Latinos (MCP-L) can reduce anxiety and depression and improve quality of life compared with CBT in Spanish-speaking adults with advanced cancer.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York and 1 other locations · NCT07225309

• Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors

  This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.

  Recruiting at 18 sites AstraZeneca · Birmingham, Alabama and 17 other locations · NCT07124000

• 24 mg versus 10 mg daily lenvatinib for symptomatic or progressive radioactive iodine–resistant differentiated thyroid cancer

  This trial tests whether a higher (24 mg) or lower (10 mg) daily dose of lenvatinib works better and is easier to tolerate for people with symptomatic or progressive radioactive iodine–resistant differentiated thyroid cancer.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07092514

• Prevalence of hidden thyroid cancer in people with Graves' disease having a total thyroidectomy.

  This project will see how common incidental thyroid cancer is in adults with Graves' disease who are having their thyroid removed and which clinical features or nodules predict it.

  Recruiting Minia University · Minya, Minya Governorate · NCT07059507

• Decision guide for radioactive iodine treatment in intermediate-risk thyroid cancer

  This study tests whether a web-based decision aid helps adults newly diagnosed with intermediate-risk differentiated thyroid cancer decide about radioactive iodine treatment, compared with standard American Cancer Society information.

  Recruiting at 3 sites Georgetown University · Washington D.C., District of Columbia and 2 other locations · NCT06980103

• Using I-124 PET/CT to find metastatic thyroid cancer

  This will try I-124 PET/CT scans to see if they detect metastatic thyroid cancer better than the usual I-123 or I-131 scans in people treated for differentiated thyroid cancer.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06961084

• Zanzalintinib before surgery for advanced thyroid cancer

  This will try zanzalintinib before surgery in adults with advanced or locally invasive thyroid cancers to shrink tumors and make surgery safer and less complex.

  Recruiting at 5 sites Phase 2 M.D. Anderson Cancer Center · Boston, Massachusetts and 4 other locations · NCT06959511

• Using a new molecular probe for early diagnosis of tumors

  This study is testing a new imaging tool to see if it can help doctors find different types of tumors earlier in patients aged 18 to 75 who already have confirmed tumor lesions.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06937112

• Using radiofrequency ablation to treat low-risk thyroid cancer

  This study is testing if a new treatment called radiofrequency ablation can safely help people with low-risk thyroid cancer that is 2 cm or smaller instead of traditional surgery.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06929650

• Sacituzumab govitecan for advanced salivary gland and differentiated thyroid cancers

  This study will try sacituzumab govitecan in adults whose salivary gland cancer or radioactive-iodine–refractory differentiated thyroid cancer has spread or come back and cannot be removed by surgery.

  Recruiting Phase 2 National University Hospital, Singapore · Singapore · NCT06923826

• Using an educational video to improve understanding and confidence in thyroid surgery

  This study tests if watching a short video about thyroid surgery can help people with thyroid nodules feel more confident and satisfied compared to just getting information from their doctor.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT06918223

• Combining XL092 and cemiplimab for BRAF V600E–wildtype anaplastic thyroid cancer

  This trial will test whether giving XL092 plus cemiplimab before surgery is safe and doable for adults with BRAF V600E–wildtype anaplastic thyroid cancer.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Boston, Massachusetts and 1 other locations · NCT06902376

• Analyzing genetic changes in different types of thyroid cancer

  This study is testing how genetic changes in different types of thyroid cancer can help improve diagnosis and treatment for adults with these cancers.

  Recruiting Irccs Synlab Sdn · Naples · NCT06878534

• Treatment of advanced thyroid cancer with AL2846 capsules

  This study is testing if AL2846 capsules can help people with advanced thyroid cancer that hasn't responded to other treatments live longer without their cancer getting worse.

  Recruiting Phase 3 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Hefei, Anhui and 34 other locations · NCT06860971

• ImmunoPET imaging for solid tumors targeting Trop2

  This study is testing a new imaging method to see if it can help diagnose solid tumors like bladder and prostate cancer better than current methods.

  Recruiting Phase 2/3 RenJi Hospital · Shanghai · NCT06851663

• Evaluating the Idylla ThyroidPrint Assay for Indeterminate Thyroid Nodules

  This study is testing if the Idylla ThyroidPrint Assay can help doctors better understand indeterminate thyroid nodules by comparing its results to those from surgery.

  Recruiting Royal Cornwall Hospitals Trust · Truro, Cornwall · NCT06849284

• High-resolution imaging to check if tumors are completely removed during surgery

  This study is testing if high-resolution imaging during surgery can help make sure all tumors are removed in patients with different types of cancer, like breast, prostate, and thyroid, to improve their treatment outcomes.

  Recruiting Algemeen Ziekenhuis Maria Middelares · Ghent, Oost Vlaanderen · NCT06835426

• Using 68Ga-FAPI PET/CT to find thyroid cancer recurrence after surgery

  This study is testing if a special type of scan can help find thyroid cancer that has come back after surgery in patients who are at risk for recurrence.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06800768

• Radiofrequency ablation vs hemithyroidectomy for small thyroid cancers

  This trial tests whether radiofrequency ablation can treat small thyroid cancers as effectively as hemithyroidectomy in adults with tumors under 2 cm.

  Recruiting University of Aarhus · Aarhus · NCT06796348

• Combining Donafenib and Anti-PD-1 Antibody for Treating Advanced Thyroid Cancer

  This study is testing if combining Donafenib with an anti-cancer antibody can help shrink tumors in patients with advanced thyroid cancer before they have surgery.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06787911

• Improving prediction for challenging thyroid surgeries

  This study is testing a new way to predict how challenging thyroid surgeries will be by looking at different health factors to help doctors perform the surgery better.

  Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06738888

• Evaluating 68Ga-FAPI PET/CT for Thyroid Cancer with Lymph Node Metastases

  This study is testing a new type of imaging called 68Ga-FAPI PET/CT to see if it helps doctors better assess thyroid cancer in patients with lymph node spread before surgery.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06730529

• Developing a scoring tool for robotic thyroid surgery performance

  This study is trying to create a scoring tool to help doctors measure how well they perform robotic thyroid surgeries, with the aim of improving patient care.

  Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06730321

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Examining the impact of iodine nutrition on thyroid cancer outcomes

  This study looks at how iodine levels in different areas affect the outcomes and characteristics of thyroid cancer in patients who have had thyroid surgery.

  Recruiting Shandong Provincial Hospital · Jinan, Shandong · NCT06623500

• Using radiotherapy alongside radioiodine for high-risk thyroid cancer

  This study tests if adding radiotherapy to radioiodine treatment can help people with high-risk thyroid cancer live longer without their cancer coming back after surgery.

  Recruiting Phase 3 Fudan University · Shanghai · NCT06558981

• Selective versus modified neck dissection for papillary thyroid cancer

  This study tests whether removing only selected lateral neck lymph nodes (selective neck dissection) gives similar cancer control but better quality of life than a more extensive modified neck dissection for people with papillary thyroid cancer who have 1–2 small metastatic nodes in the lateral neck.

  Recruiting Phase 3 Fudan University · Shanghai · NCT06554652

• Using RET inhibitors before surgery for advanced thyroid cancer

  This study is testing whether using RET inhibitors before surgery can help people with advanced thyroid cancer that has specific genetic changes.

  Recruiting Fudan University · Shanghai · NCT06530316

• Observing the effects of radiotherapy in advanced thyroid cancer

  This study is testing if adding radiotherapy after surgery can help people with advanced thyroid cancer avoid their cancer coming back.

  Recruiting Fudan University · Shanghai · NCT06524167

• Registry of outcomes for patients with advanced thyroid cancer

  This study looks at how well different treatments work for people with advanced thyroid cancer, comparing those treated at MD Anderson Cancer Center to those treated elsewhere, while also checking how these treatments affect their quality of life.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06507878

• Optimizing Levothyroxine Dosage for Patients After Thyroid Surgery

  This study is testing a new tool that helps find the right dose of levothyroxine faster for people who have had their thyroid removed, to see if it improves their health and ability to work compared to regular care.

  Recruiting at 3 sites University Hospital of North Norway · Bergen and 2 other locations · NCT06455371

• Using I-124 PET/CT imaging for thyroid cancer evaluation

  This study is testing a new type of imaging to see if it can help doctors better understand and treat thyroid cancer in both newly diagnosed patients and those with ongoing concerns.

  Recruiting Miami Cancer Research Center, Inc. · North Miami, Florida · NCT06443866

• Impact of nerve monitoring on voice quality after thyroid surgery

  This study tests whether using nerve monitoring during thyroid surgery can help improve voice quality for patients after the operation.

  Recruiting Fujian Medical University · Fuzhou, Fujian · NCT06254859

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• Exploring the unmet needs of cancer survivors in Reggio Emilia

  This study is trying to find out what cancer survivors need most after finishing their treatment to help improve their care and quality of life.

  Recruiting University of Modena and Reggio Emilia · Reggio Emilia, Reggio Emilia · NCT06236373

• Surgery for thyroid cancer using autofluorescence imaging

  This study is testing if using special imaging during thyroid cancer surgery can help lower the chances of patients developing low parathyroid hormone levels afterward.

  Recruiting Aarhus University Hospital · Aarhus, Denmark · NCT06222606

• Immediate biopsy versus active ultrasound monitoring for suspicious thyroid nodules

  This will try immediate biopsy versus careful ultrasound monitoring to see which causes less anxiety and better thyroid-related quality of life for adults with newly found suspicious thyroid nodules (TI‑RADS 4–5) that are 2 cm or smaller.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06220656

• Observing symptoms after thyroid surgery in cancer patients

  This study looks at how patients with thyroid cancer feel and recover after thyroid surgery to see how well their symptoms are managed and what factors might affect their recovery.

  Recruiting at 3 sites Ilsan Cha hospital · Gyeonggi-do and 2 other locations · NCT06158360

• Comparing neck dissection techniques for thyroid cancer treatment

  This study is testing two different surgical methods for removing lymph nodes in patients with thyroid cancer to see which one causes fewer problems afterward.

  Recruiting Centro de Excelencia en Enfermedades de Cabeza y Cuello · Medellín, Antioquia · NCT06149637

• Thyroxine therapy after thyroid surgery for low-risk cancer

  This study tests if taking thyroxine after surgery for low-risk thyroid cancer can help keep patients healthy and prevent the cancer from coming back.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06087068

• Prophylactic central neck dissection for low-risk papillary thyroid cancer

  This study is testing if a specific type of surgery can help people with low-risk thyroid cancer live longer and have fewer recurrences of the disease.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06082180

• Combination treatment for thyroid cancer using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help patients with hard-to-treat thyroid cancer feel better and have more options for their treatment.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06007924

• Using artificial tears to prevent tear duct blockage after thyroid cancer treatment

  This study tests if using artificial tears can help prevent tear duct blockages in people who have had radioactive iodine treatment for thyroid cancer.

  Recruiting Phase 3 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05999630

• Investigating the role of ctDNA in advanced thyroid cancer

  This study is trying to see if analyzing blood samples for tumor DNA can help doctors better understand and treat advanced thyroid cancer.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT05837260

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

• Evaluating the impact of treatments and clinical factors on thyroid cancer outcomes

  This study looks at how different treatments and health factors affect the outcomes for people with thyroid cancer to help identify which patients might need less aggressive treatment.

  Recruiting Istituto Auxologico Italiano · Milan · NCT05752604

• Collecting information on redifferentiating medications for thyroid cancer treatment

  This study is trying to see how well new medications for thyroid cancer work for patients who haven't responded to standard treatments and how they affect future therapies.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT05733013

• Metformin and fertility after 131I treatment for thyroid cancer

  This study tests whether metformin can help preserve or improve fertility in women of reproductive age who have thyroid cancer treated with radioactive iodine.

  Recruiting at 2 sites Phase 3 Medical University of Bialystok · Bialystok and 1 other locations · NCT05468554

• Validation of a blood test for early cancer detection and monitoring

  This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.

  Recruiting at 3 sites Adela, Inc · Duarte, California and 16 other locations · NCT05366881

• Investigating how environmental factors affect thyroid cancer

  This study is trying to see how different environmental factors might influence the development and progression of thyroid cancer in adults who have been diagnosed with it.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT05172921

• Improving care for rural patients with solid tumors

  This study is testing a new support program to see if it helps rural patients with solid tumors start and finish their treatment faster compared to usual care.

  Recruiting at 14 sites University of Colorado, Denver · Aurora, Colorado and 13 other locations · NCT04916990

• Comparing two methods of radioiodine treatment for thyroid cancer

  This study is testing two different ways to give radioiodine treatment to people with thyroid cancer to see which method works better for them after surgery.

  Recruiting at 28 sites Phase 3 Centre Francois Baclesse · Pointe à Pitre, Guadeloupe and 28 other locations · NCT04290663

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Database for patients treated with metabolic radiotherapy

  This study is creating a database to collect information and samples from patients with thyroid, prostate, and neuroendocrine tumors who are receiving targeted radiation therapy, to see how it works and improve treatment.

  Recruiting at 3 sites Institut du Cancer de Montpellier - Val d'Aurelle · Bordeaux, Aquitaine and 3 other locations · NCT04104529

• Using advanced imaging to improve treatment for thyroid cancer

  This study is testing a new imaging method to see if it can help doctors give the right amount of radioactive iodine treatment to people with high-risk thyroid cancer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03841617

• Registration of patients with thyroid cancer

  This study is collecting information on adults with different types of thyroid cancer to better understand their experiences and outcomes.

  Recruiting Grupo Espanol de Tumores Neuroendocrinos · Barcelona, Barcelona · NCT03765333

• Examining quality of life in thyroid cancer and tumours

  This study looks at how surgery for thyroid cancer and tumors affects the quality of life for patients over time.

  Recruiting Oslo University Hospital · Oslo · NCT03676348

• Exploring new MRI techniques for head and neck cancers

  This study is testing new MRI techniques to see if they can give better details about head and neck tumors in patients getting treatment for cancer.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT03483337

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Understanding genetic risks for thyroid cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of thyroid cancer by looking at the family and medical histories of people with thyroid cancer or nodules.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT02747888

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Understanding thyroid tumors and their treatment

  This study is trying to learn more about thyroid nodules and cancer by looking at how well current treatments work and testing new ways to diagnose and treat these conditions in patients.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001160

NIH-funded research (35)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• WTC Dust and Thyroid Cancer Progression in Human Organoids

  This grant tests how World Trade Center dust might influence thyroid cancer progression using human thyroid organoids to model real-life exposure.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11578742

• Integrating molecular signals to guide thyroid cancer care

  A doctor-scientist team at Brigham and Women’s Hospital is studying how tumor biology and the immune environment can guide personalized monitoring and treatment for differentiated thyroid cancer.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11452026

• Metabolic Imaging to Track Treatment Response in Aggressive Thyroid Cancer

  This grant explores a new way to watch how aggressive thyroid cancers respond to treatment using a special MRI technique that tracks tumor metabolism.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11420949

• Adoptive T-cell Therapy for Anaplastic Thyroid Cancer

  A patient-focused program explores using patient immune cells engineered to target and fight anaplastic thyroid cancer, especially for those whose cancer has stopped responding to standard treatments.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11420948

• Overcoming Resistance to BRAF Inhibitors in Aggressive Thyroid Cancers

  A patient-focused research effort to find new ways to treat difficult thyroid cancers that no longer respond to current BRAF inhibitors.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11420947

• Improving Treatment of Anaplastic Thyroid Cancer with New Therapies and Early Response Checks

  This NIH grant aims to advance treatment for a rare, aggressive thyroid cancer by testing new approaches and measuring how tumors respond early in treatment to tailor care.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11420945

• Optimizing thyroid nodule care to reduce thyroid cancer burden

  A doctor-scientist at a major university is exploring better ways to manage thyroid nodules in adults to lower the risk and impact of thyroid cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11376160

• Preference-based value of thyroid cancer treatments for small tumors

  This grant asks how patients feel about different PTMC treatments (watchful waiting, partial/total thyroidectomy, or radiofrequency ablation) and how those feelings affect overall care decisions.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11369995

• Targeting clonal blood cell changes to overcome therapy resistance in thyroid cancer

  This research tests how clonal blood cell changes influence treatment response in elderly patients with aggressive thyroid cancer and aims to improve outcomes when MAPK inhibitors are used.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11366718

• Mortalin's role in thyroid cancer metabolism and therapy

  This project looks at how mortalin supports thyroid cancer cell metabolism and whether targeting these metabolic pathways could kill cancer cells.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11349702

• Online support for people with differentiated thyroid cancer after radioactive iodine treatment

  A web-based program to help people with differentiated thyroid cancer manage side effects and improve quality of life after radioactive iodine treatment.

  NIH research Georgetown University · Washington, United States · NIH-11311315

• Tailored follow-up care for thyroid cancer survivors

  This project will create personalized follow-up plans to reduce unneeded tests and worry for people who have finished treatment for thyroid cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11300961

• Decision tool to help you choose radioactive iodine after intermediate-risk thyroid cancer

  A patient-friendly decision aid will help people with intermediate-risk thyroid cancer weigh the benefits and risks of adding radioactive iodine after surgery.

  NIH research Georgetown University · Washington, United States · NIH-11294188

• AI-enhanced optical imaging to improve thyroid nodule diagnosis

  This project uses advanced, label-free optical imaging plus AI to help doctors tell which thyroid nodules are harmless and which need treatment.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11251733

• A web-based support tool for patients with thyroid cancer after treatment

  This study is testing a helpful online tool called iSupport for people with differentiated thyroid cancer who have had radioactive iodine treatment, to provide them with useful information and support to make their recovery easier and improve their quality of life.

  NIH research Georgetown University · Washington, United States · NIH-11231962

• DNA methylation test to distinguish benign from cancerous thyroid nodules

  This project is testing a DNA methylation-based test to help people with unclear thyroid nodules find out if they are benign or cancerous.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11231264

• Helping patients with intermediate-risk thyroid cancer make decisions about radioactive iodine treatment

  This study is here to help people with intermediate-risk thyroid cancer understand the pros and cons of using radioactive iodine treatment after surgery, so they can make informed choices about their care.

  NIH research Georgetown University · Washington, United States · NIH-11225699

• Finding better treatments for anaplastic thyroid cancer based on genetic mutations

  This study is looking at how certain gene changes in patients with anaplastic thyroid cancer can affect how well radiation therapy works, with the goal of finding better treatment options that are tailored to each person's unique genetic makeup.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11159515

• Understanding Mortalin's Role in Thyroid Cancer

  This project explores how a protein called mortalin helps thyroid cancer grow, hoping to find new ways to stop it.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11146416

• Understanding Thyroid Cancer in World Trade Center Survivors

  This project looks at how exposure to World Trade Center dust might be connected to thyroid cancer in people who were there, especially those who were children or teenagers at the time.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11081609

• Improving care for thyroid cancer survivors by assessing their risk of recurrence

  This study is looking to improve the follow-up care for people who have survived thyroid cancer by finding a better way to understand their chances of the cancer coming back, so they can get the right level of care without unnecessary stress.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11075898

• A new method to personalize treatment for iodine-refractory thyroid cancer

  This study is looking for better ways to treat patients with iodine-refractory thyroid cancer by creating tiny models of the cancer to test new treatments that might help the cancer cells absorb radioactive iodine again, which could lead to more personalized and effective care for you.

  NIH research Stanford University · Stanford, United States · NIH-11075322

• Understanding the genetics of thyroid cancer to improve diagnosis

  This study is looking at the genes linked to thyroid cancer to help doctors better tell the difference between harmless and harmful thyroid nodules, which could mean fewer unnecessary biopsies and less worry for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11061086

• Enhancing the effectiveness of radioiodine treatment for thyroid cancer

  This study is looking at how to make radioiodine therapy work better for people with advanced thyroid cancer who haven't had much success with other treatments, by adding special medications that might help the cancer cells absorb the iodine more effectively.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11051244

• Improving thyroid cancer diagnosis using advanced AI technology

  This study is working on a new way to help doctors better diagnose thyroid cancer using advanced imaging technology, which could lead to more accurate results and fewer unnecessary procedures for patients with thyroid nodules.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11047378

• Testing new biomarkers to improve thyroid cancer diagnosis

  This study is testing a new DNA test that looks at specific patterns to help doctors tell the difference between harmless and cancerous thyroid nodules, so patients can avoid unnecessary surgeries.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-10991407

• Evaluating treatment options for low-risk thyroid cancer

  This study is looking at how different treatment options for low-risk thyroid cancer, like active monitoring or surgery, affect patients' experiences and preferences, so we can better understand what matters most to you when choosing a treatment.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10947007

• Investigating genetic risks for aggressive thyroid cancer in male veterans

  This study is looking at how genes and environmental factors, like exposure to toxins, affect aggressive thyroid cancer in veterans, especially men, to help find better ways to diagnose and treat this condition.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-10919300

• Investigating the link between World Trade Center exposure and thyroid cancer in survivors

  This study is looking at whether breathing in dust from the World Trade Center affects the risk of thyroid cancer in kids and teens who were exposed, and it aims to understand how this exposure might lead to more serious cases of the disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10903700

• Reducing unnecessary surgeries for low-risk thyroid cancer patients

  This study is looking to help people with low-risk papillary thyroid cancer by giving them clear information about their treatment choices, so they can talk with their doctors and feel confident in choosing less invasive options instead of having unnecessary surgery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10895437

• Understanding how mortalin affects thyroid cancer

  This study is looking at a protein called mortalin in thyroid cancer to see how it helps cancer cells survive and manage energy, with the hope that finding ways to target this protein could lead to new treatments for patients.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10884160

• Targeting a specific cell death pathway in a type of aggressive thyroid cancer.

  This study is looking at a new treatment for anaplastic thyroid cancer that has a specific mutation, aiming to see if combining two types of drugs can help make the cancer cells die more effectively, which could lead to better results for patients facing this tough condition.

  NIH research Stanford University · Stanford, United States · NIH-10877833

• Investigating a new suppressor of thyroid cancer metastasis

  This study is looking at how thyroid cancer spreads and aims to find ways to stop it, focusing on a new factor called RCAN1.4 that could help develop better treatments for people with advanced thyroid cancer.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10828373

• Understanding and reducing unnecessary thyroid cancer diagnoses

  This study is looking at how we can reduce the number of people diagnosed with thyroid cancer that they don’t actually need treatment for, by using math and engineering to understand what causes these overdiagnoses and how changes in medical practices can help keep patients from getting unnecessary treatments.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10827894

• Improving thyroid cancer imaging with a new camera technology

  This study is testing a new type of camera that helps doctors see thyroid nodules more clearly, which can lead to earlier and more accurate diagnoses of thyroid cancer, all while keeping radiation exposure low for patients.

  NIH research University of Massachusetts Lowell · Lowell, United States · NIH-10286795

Related topics

Quick answers

How many Thyroid Cancer clinical trials are recruiting right now?

80, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (28 trials), China (27 trials), France (5 trials), Italy (5 trials), Spain (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 12, Phase 3: 7, Phase 1: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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