Impact of nerve monitoring on voice quality after thyroid surgery

Intraoperative Neuromuscular Monitoring and Its Impact on Pre- and Postoperative Acoustic Outcomes in Thyroid Surgery

Observational Fujian Medical University · NCT06254859

This study tests whether using nerve monitoring during thyroid surgery can help improve voice quality for patients after the operation.

Quick facts

Study typeObservational
Enrollment100 (estimated)
SexAll
SponsorFujian Medical University Academic / other
Locations1 site (Fuzhou, Fujian)
Trial IDNCT06254859 on ClinicalTrials.gov

What this trial studies

This study examines how changes in intraoperative recurrent laryngeal nerve monitoring signals affect the voice quality of patients undergoing thyroid surgery. By analyzing surgical data and postoperative voice recordings, the research aims to identify patterns in these signals and their correlation with voice outcomes. The goal is to enhance surgical practices and improve patient well-being by providing insights into nerve function during surgery. This comprehensive analysis seeks to contribute valuable knowledge to the field of thyroid surgery.

Who should consider this trial

Good fit: Ideal candidates are adults aged 20-60 scheduled for conventional unilateral thyroid lobectomy with isthmus resection and central compartment lymph node dissection.

Not a fit: Patients with a history of head and neck surgeries, vocal cord disorders, or neurological conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical techniques that enhance voice quality after thyroid surgery.

How similar studies have performed: Other studies have shown success in using intraoperative nerve monitoring to improve surgical outcomes, indicating a promising approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 20-60 years old.
* Planned conventional unilateral thyroid lobectomy + isthmus resection + central compartment lymph node dissection.

Exclusion Criteria:

* History of past head and neck surgeries.
* Pronunciation system defect and disorder history.
* History of vocal cord polyps or nodules.
* History of upper respiratory tract infection in the 2 weeks before surgery or postoperative infection history.
* History of neurological disorders.
* Abnormalities in the throat.
* Preoperative damage to throat morphology or motor function.
* Preoperative functional voice or language disorders, noticeable hoarseness, or difficulty in pronunciation.
* Pre- and postoperative laryngoscopic examination showing vocal cord paralysis and arytenoid joint dislocation.
* Neurological disorders causing abnormal throat function.
* Patient unable to cooperate with VHI (Voice Handicap Index) assessment and voice spectrum examination.

Where this trial is running

Fuzhou, Fujian

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Thyroid CancerThyroid Cancer, Papillaryacoustic analysisthyroid cancer
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.