Understanding how mortalin affects thyroid cancer
Official title: The Role of Mortalin in Thyroid Cancer
Funded at Medical College of Wisconsin · NIH-10884160 · Data updated 2026-11-12
This study is looking at a protein called mortalin in thyroid cancer to see how it helps cancer cells survive and manage energy, with the hope that finding ways to target this protein could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $409,836 |
| NIH project number | 5R01CA269452-02 |
| Project ID | NIH-10884160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with thyroid cancer who may benefit from novel therapeutic approaches.
✕Less likely to help
Patients with non-cancerous thyroid conditions or those with advanced thyroid cancer that has not responded to other treatments may not benefit from this research.
What this research studies
This research investigates the role of a protein called mortalin in thyroid cancer, focusing on how it helps tumor cells manage their energy and survive under stress. The team aims to uncover the mechanisms that lead to increased levels of mortalin in these cancer cells and explore whether targeting this protein could be a new way to treat thyroid cancer. By analyzing data from previous studies and conducting experiments on thyroid tumor cell lines, they hope to identify potential therapeutic strategies that could lead to improved outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for thyroid cancer patients by targeting metabolic processes that support tumor growth.
How similar studies have gone: Previous research has shown promising results in targeting metabolic processes in cancer treatment, suggesting that this approach may hold potential for thyroid cancer as well.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Park, Jong-in — Medical College of Wisconsin
- Study coordinator: Park, Jong-in
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.