Investigating a new suppressor of thyroid cancer metastasis
Official title: RCAN 1.4 metastasis suppressor in thyroid cancer
Funded at Ohio State University · NIH-10828373 · Data updated 2026-11-12
This study is looking at how thyroid cancer spreads and aims to find ways to stop it, focusing on a new factor called RCAN1.4 that could help develop better treatments for people with advanced thyroid cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $431,712 |
| NIH project number | 5R01CA240302-05 |
| Project ID | NIH-10828373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced or metastatic thyroid cancer.
✕Less likely to help
Patients with early-stage thyroid cancer or non-thyroid cancers may not benefit from this research.
What this research studies
This research focuses on understanding how thyroid cancer spreads and identifying key factors that can prevent this progression. By analyzing genetic changes in metastatic thyroid cancer tissues, the team has discovered a new metastasis suppressor called RCAN1.4. They are using advanced techniques, including genomic analysis and studies in human cell lines and mouse models, to explore how the loss of RCAN1.4 affects cancer cell behavior and immune responses. The goal is to uncover mechanisms that could lead to new treatments for patients with advanced thyroid cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent the spread of thyroid cancer, improving survival rates for patients.
How similar studies have gone: Other research has shown success in identifying metastasis suppressors in various cancers, suggesting that this approach could yield valuable insights for thyroid cancer as well.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Ringel, Matthew D — Ohio State University
- Study coordinator: Ringel, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.