How changing thyroid hormone levels affects blood sugar, lipids, and energy use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare people whose thyroid hormone levels are intentionally lowered for Graves' disease with people whose thyroid hormones are raised as part of thyroid cancer care. Oral glucose tolerance tests will be done before treatment, two weeks after starting treatment, and three months after starting treatment to track changes over time. Metabolic measures will include blood glucose, insulin secretion and sensitivity, lipid levels, resting energy expenditure, respiratory quotient, and measures of liver fat, eating, and physical activity. The goal is to clarify how clinical changes in thyroid hormone levels alter human glucose and energy metabolism.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with initial diagnosis of graves disease OR
* patients with initial diagnosis of thyroid carcinoma

Exclusion Criteria:

* contraindications for oral glucose tolerance test
* Diabetes mellitus
* Fasting glucose level ≥ 200 mg/dL
* Exogenous insulin administration with action at the time of the test
* Current disease with activation of stress hormones
* Post-aggressive metabolism
* Acute infectious disease

Where it's running

• Ulm University Hospital
  Ulm, Baden-Wurttemberg, Germany Recruiting

Study contacts

• Principal investigator: Martin Heni — University of Ulm
• Study coordinator: Martin Heni, Prof
• Email: martin.heni@uniklinik-ulm.de
• Phone: +4973150044505

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Early risk stratification of thyroid eye disease in newly diagnosed Graves' disease

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• Selective coverage radiotherapy vs. full coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer

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  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07777536

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.