Bilateral neck block during thyroid surgery to see if stress markers change
Official title: The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy
Run by University Hospital Dubrava · NCT07600580 · Data updated 2026-11-12
Researchers will test whether adding a bilateral intermediate cervical plexus block to the anesthesia during total thyroidectomy helps reduce the surgical stress response in adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | University Hospital Dubrava Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Zagreb, City of Zagreb) |
| Status | Recruiting |
| Started | May 13, 2024 |
| Main results expected | February 3, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07600580 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with euthyroid status, ASA I–II, scheduled for total thyroidectomy, who provide informed consent.
✕Probably not a fit
Patients with contraindications to nerve block, thyroid disease outside euthyroid status, or those who do not receive the block may not experience reduced stress biomarkers.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two anesthesia strategies in adults undergoing total thyroidectomy: standard total intravenous anesthesia (TIVA) alone versus TIVA plus a bilateral intermediate cervical plexus block with levobupivacaine. The trial will measure stress and inflammatory biomarkers in saliva and blood to assess the surgical stress response. It is conducted at University Hospital Dubrava and plans to enroll 48 participants, randomized 1:1. The study is single-blinded for participants, with outcomes focused on objective biomarker changes related to surgical stress. If the block reduces the stress response, it could support updating anesthetic protocols for thyroid surgery.
Why it matters
Potential benefit: If successful, the approach could lessen the physiological stress of thyroidectomy and improve postoperative recovery markers.
How similar studies have gone: Previous work has explored regional blocks to modulate surgical stress, but this specific bilateral intermediate cervical plexus block with biomarkers in thyroidectomy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patienets of both sexes * 18 years of age and older * ASA I or ASA II * euthyroid status * signed informed consent Exclusion Criteria: * patients who refuse to sign the informed consent form * infection at the block injection site * hypersensitivity or contraindications to the medications used in the study * hypothyroidism or hyperthyroidism at the time of surgery * presence of substernal goiter * additional surgical interventions during the procedure * history of previous neck surgery or radiation * coagulopathy * uncontrolled respiratory disease * diabetes mellitus * autoimmune disease * chronic corticosteroid therapy * smokers * pregnant women.
Where it's running
-
University Hospital Dubrava
Zagreb, City of Zagreb, Croatia Recruiting
Study contacts
- Study coordinator: Antonija Mihelčić
- Email: antonijamihelcic@yahoo.com
- Phone: +385996830715
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.