Clinical trial Recruiting at 1 site Interventional Ages 18 to 100

Using radiofrequency ablation to treat low-risk thyroid cancer

Official title: Thermo-Ablation With Radiofrequency Medical Technologies to Treat Thyroid Cancers

Run by University Health Network, Toronto · NCT06929650 · Data updated 2026-11-12

This study is testing if a new treatment called radiofrequency ablation can safely help people with low-risk thyroid cancer that is 2 cm or smaller instead of traditional surgery.

Quick facts

Study typeInterventional
Ages18 Years to 100 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity Health Network, Toronto
Academic / other
Locations1 site (Toronto, Ontario)
StatusRecruiting
StartedApril 20, 2023
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedApril 16, 2025
Trial IDNCT06929650 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 100 with thyroid nodules ≤2 cm that are classified as Bethesda 5/6.

Probably not a fit

Patients under 18, pregnant women, those with invasive or metastatic thyroid cancer, or those previously treated for thyroid cancer may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the safety and feasibility of radiofrequency ablation (RFA) for treating low-risk thyroid cancers that are 2 cm or smaller. Participants will undergo pre-procedural scans and the RFA procedure, followed by three follow-up appointments at 4 weeks, 6 months, and 12 months to monitor their recovery and any potential complications. The study is conducted at the University Health Network in Toronto and seeks to determine if RFA can be a viable alternative to traditional surgery for these patients.

Why it matters

Potential benefit: If successful, this approach could provide a less invasive treatment option for patients with low-risk thyroid cancer, potentially preserving their quality of life.

How similar studies have gone: Other studies have shown promising results with radiofrequency ablation for similar conditions, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1\. Patients with:

* Nodule less than or equal to 2cm in size

  a. Specifically: Bethesda 5/6
* Their age is ≥18 years and ≤100 years
* Able to provide written consent
* Able to attend required follow-ups as per the protocol

Exclusion Criteria:

* Patients \<18 years old
* Pregnant women
* Any concern for invasive or metastatic thyroid cancer
* Previously treated for thyroid cancer

Where it's running

  • University Health Network
    Toronto, Ontario, Canada
    Recruiting

Study contacts

  • Principal investigator: Jesse D Pasternak, MD, MPH — University Health Network (UHN) Toronto
  • Study coordinator: Jesse Pasternak
  • Email: jesse.pasternak@uhn.ca
  • Phone: (416) 340-4792

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Low calcium after thyroid removal

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    Recruiting Minia University · Minya, Minya Governorate · NCT07428057

  • Active monitoring for small Bethesda IV thyroid nodules

    This program will try active monitoring with scheduled ultrasounds and clinic visits instead of immediate surgery for adults with a single Bethesda IV thyroid nodule under 2 cm.

    Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07370675

  • Improving prediction for challenging thyroid surgeries

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    Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06738888

  • Developing a scoring tool for robotic thyroid surgery performance

    This study is trying to create a scoring tool to help doctors measure how well they perform robotic thyroid surgeries, with the aim of improving patient care.

    Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06730321

  • Immediate biopsy versus active ultrasound monitoring for suspicious thyroid nodules

    This will try immediate biopsy versus careful ultrasound monitoring to see which causes less anxiety and better thyroid-related quality of life for adults with newly found suspicious thyroid nodules (TI‑RADS 4–5) that are 2 cm or smaller.

    Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06220656

  • Examining quality of life in thyroid cancer and tumours

    This study looks at how surgery for thyroid cancer and tumors affects the quality of life for patients over time.

    Recruiting Oslo University Hospital · Oslo · NCT03676348

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.