Using radiofrequency ablation to treat low-risk thyroid cancer
Official title: Thermo-Ablation With Radiofrequency Medical Technologies to Treat Thyroid Cancers
Run by University Health Network, Toronto · NCT06929650 · Data updated 2026-11-12
This study is testing if a new treatment called radiofrequency ablation can safely help people with low-risk thyroid cancer that is 2 cm or smaller instead of traditional surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | April 20, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | April 16, 2025 |
| Trial ID | NCT06929650 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 100 with thyroid nodules ≤2 cm that are classified as Bethesda 5/6.
✕Probably not a fit
Patients under 18, pregnant women, those with invasive or metastatic thyroid cancer, or those previously treated for thyroid cancer may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the safety and feasibility of radiofrequency ablation (RFA) for treating low-risk thyroid cancers that are 2 cm or smaller. Participants will undergo pre-procedural scans and the RFA procedure, followed by three follow-up appointments at 4 weeks, 6 months, and 12 months to monitor their recovery and any potential complications. The study is conducted at the University Health Network in Toronto and seeks to determine if RFA can be a viable alternative to traditional surgery for these patients.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive treatment option for patients with low-risk thyroid cancer, potentially preserving their quality of life.
How similar studies have gone: Other studies have shown promising results with radiofrequency ablation for similar conditions, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Patients with: * Nodule less than or equal to 2cm in size a. Specifically: Bethesda 5/6 * Their age is ≥18 years and ≤100 years * Able to provide written consent * Able to attend required follow-ups as per the protocol Exclusion Criteria: * Patients \<18 years old * Pregnant women * Any concern for invasive or metastatic thyroid cancer * Previously treated for thyroid cancer
Where it's running
-
University Health Network
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Jesse D Pasternak, MD, MPH — University Health Network (UHN) Toronto
- Study coordinator: Jesse Pasternak
- Email: jesse.pasternak@uhn.ca
- Phone: (416) 340-4792
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Immediate biopsy versus active ultrasound monitoring for suspicious thyroid nodules
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This study looks at how surgery for thyroid cancer and tumors affects the quality of life for patients over time.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.