Condition

Thyroid Nodule clinical trials and research

• 17Clinical trials
• 3NIH research projects
• 8Countries

Newest Thyroid Nodule clinical trials

All recruiting trials (17)

• NIRAF-guided identification of parathyroids during thyroidectomy

  A wearable near-infrared autofluorescence device is being tested to help surgeons find and protect the parathyroid glands during thyroid surgery in adults.

  Recruiting Ss. Cyril and Methodius University of Skopje · Skopje · NCT07617584

• Combining ultrasound and cytology whole-slide images to predict cancer risk in indeterminate (Bethesda III) thyroid nodules

  This project will test whether a deep learning model that merges ultrasound pictures and cytology whole-slide images can better predict which Bethesda III thyroid nodules are cancerous.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangzhou · NCT07488325

• Low calcium after thyroid removal

  This project will see if clinical, lab, and surgical factors predict low calcium after thyroid surgery in adults treated at Minia University Hospital from 2014–2024.

  Recruiting Minia University · Minya, Minya Governorate · NCT07428057

• Active monitoring for small Bethesda IV thyroid nodules

  This program will try active monitoring with scheduled ultrasounds and clinic visits instead of immediate surgery for adults with a single Bethesda IV thyroid nodule under 2 cm.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07370675

• Multiparametric ultrasound imaging for pancreatic risk screening and thyroid nodules

  This project will try multiparametric ultrasound (mpUS) to see if it gives clearer pictures of pancreatic tissue for people at high risk for pancreatic cancer and of thyroid nodules for people being evaluated for those lumps.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07270237

• Using radiofrequency ablation to treat low-risk thyroid cancer

  This study is testing if a new treatment called radiofrequency ablation can safely help people with low-risk thyroid cancer that is 2 cm or smaller instead of traditional surgery.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06929650

• Improving prediction for challenging thyroid surgeries

  This study is testing a new way to predict how challenging thyroid surgeries will be by looking at different health factors to help doctors perform the surgery better.

  Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06738888

• Treatment for indeterminate thyroid nodules using myo-inositol and selenium

  This study is testing if a six-month treatment with a supplement of myo-inositol and selenium can help reduce the size and improve the elasticity of certain thyroid nodules in patients.

  Recruiting Regina Elena Cancer Institute · Rome · NCT06736015

• Ultrasound-guided thermal ablation for certain thyroid nodules

  This study tests whether a special heat treatment using ultrasound can safely help people with certain thyroid nodules who can't or don't want to have surgery.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06733753

• Developing a scoring tool for robotic thyroid surgery performance

  This study is trying to create a scoring tool to help doctors measure how well they perform robotic thyroid surgeries, with the aim of improving patient care.

  Recruiting Shanghai 6th People's Hospital · Shanghai · NCT06730321

• Evaluating quality of life and emotions in patients with thyroid nodules

  This study is testing how treatment for thyroid nodules affects the emotional well-being and quality of life of patients before and after they receive either thermal ablation or surgery.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT06610604

• Prunella oral liquid for treating benign thyroid nodules

  This trial will try two doses of Prunella oral liquid versus placebo to see if it is safe and can shrink benign thyroid nodules in adults.

  Recruiting at 22 sites Phase 4 Xintian Pharmaceutical · Chongqing, Chongqing Municipality and 21 other locations · NCT06423235

• Immediate biopsy versus active ultrasound monitoring for suspicious thyroid nodules

  This will try immediate biopsy versus careful ultrasound monitoring to see which causes less anxiety and better thyroid-related quality of life for adults with newly found suspicious thyroid nodules (TI‑RADS 4–5) that are 2 cm or smaller.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06220656

• Contrast-enhanced ultrasound to improve scoring for thyroid cancer diagnosis

  This project will test whether adding contrast-enhanced ultrasound to gray-scale ultrasound helps doctors better tell which thyroid nodules are cancerous for patients who have had biopsies.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06146764

• Radiofrequency ablation for benign thyroid nodules in LatinX patients

  This study is testing if a new, less invasive treatment called radiofrequency ablation can safely help LatinX patients with bothersome benign thyroid nodules feel better.

  Recruiting Northwell Health · New York, New York · NCT05903196

• Education on managing thyroid nodules

  This study is testing how providing information on managing small thyroid nodules helps patients feel more satisfied with their treatment choices.

  Recruiting Stony Brook University · Stony Brook, New York · NCT05264857

• Examining quality of life in thyroid cancer and tumours

  This study looks at how surgery for thyroid cancer and tumors affects the quality of life for patients over time.

  Recruiting Oslo University Hospital · Oslo · NCT03676348

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Optimizing thyroid nodule care to reduce thyroid cancer burden

  A doctor-scientist at a major university is exploring better ways to manage thyroid nodules in adults to lower the risk and impact of thyroid cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11376160

• Personalized Treatment for Thyroid Nodules

  This project uses computer modeling to find the best ways to treat thyroid nodules and cancer, aiming to help many people in the U.S.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11179274

• Optimizing treatment for thyroid nodules using personalized approaches

  This study is looking at how to better treat thyroid nodules, which many people have, by using computer models to find the best personalized treatment options, so patients with harmless nodules can avoid unnecessary procedures while ensuring those with more serious conditions get the right care.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10799193

Related topics

Quick answers

How many Thyroid Nodule clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (7 trials), United States (4 trials), Canada (1 trial), Denmark (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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