Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Surgery for thyroid cancer using autofluorescence imaging

Official title: Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism - a Randomized, Controlled Trial

Run by Aarhus University Hospital · NCT06222606 · Data updated 2026-11-12

This study is testing if using special imaging during thyroid cancer surgery can help lower the chances of patients developing low parathyroid hormone levels afterward.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment160 (estimated)
SponsorAarhus University Hospital
Academic / other
Locations1 site (Aarhus, Denmark)
StatusRecruiting
StartedJanuary 1, 2024
Main results expectedJanuary 2027
Study endsJanuary 2027
Registry record updatedOctober 6, 2025
Trial IDNCT06222606 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 years old with a suspicion or diagnosis of thyroid cancer who are scheduled for total or completion thyroidectomy.

Probably not a fit

Patients requiring simultaneous parathyroid surgery or those with severe kidney impairment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether the use of autofluorescence imaging during surgery for thyroid cancer can reduce the risk of developing hypoparathyroidism. Patients undergoing total thyroidectomy or completion hemithyroidectomy will be enrolled to assess the effectiveness of this imaging technique. The goal is to minimize treatment-related complications and improve patient outcomes following thyroid cancer surgery. The study will focus on patients with a confirmed diagnosis of thyroid cancer who are scheduled for surgery.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of hypoparathyroidism in patients undergoing thyroid cancer surgery.

How similar studies have gone: While the use of autofluorescence imaging in surgery is a relatively novel approach, preliminary studies have shown promise in reducing complications in similar surgical contexts.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age\>18 years and able to give informed consent.
* Suspicion or diagnosis of thyroid cancer.
* Planned total thyroidectomy or completion thyroidectomy.
* Normocalcemia prior to surgery.

Exclusion Criteria:

* Planned simultaneous parathyroid surgery.
* Treatment with active vitamin D analogues.
* eGFR \< 30.

Where it's running

  • Aarhus University Hospital
    Aarhus, Denmark, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.