Clinical trial Recruiting at 1 site Observational Ages 6 Months to 98

Understanding thyroid tumors and their treatment

Official title: Studies on Thyroid Nodules and Thyroid Cancer

Run by National Institutes of Health Clinical Center (CC) · NCT00001160 · Data updated 2026-11-12

This study is trying to learn more about thyroid nodules and cancer by looking at how well current treatments work and testing new ways to diagnose and treat these conditions in patients.

Quick facts

Study typeObservational
Ages6 Months to 98 Years
SexAll
Enrollment2500 (estimated)
SponsorNational Institutes of Health Clinical Center (CC)
NIH
Locations1 site (Bethesda, Maryland)
StatusRecruiting
StartedJune 1, 1977
Registry record updatedNovember 9, 2026
Trial IDNCT00001160 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults and children aged 6 months and older with known or suspected thyroid nodules or thyroid cancer.

Probably not a fit

Patients with serious underlying medical conditions that limit diagnostic testing or therapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with or suspected to have thyroid nodules or thyroid cancer. It aims to enhance the understanding of diagnostic and treatment methods for thyroid conditions by utilizing standard medical care alongside new techniques. Participants will undergo various diagnostic procedures, including imaging and biopsies, while blood and tissue samples will be collected for research purposes. The study will also evaluate the effectiveness of radioiodine therapy and the significance of serum thyroglobulin measurements in diagnosing tumor recurrence.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for thyroid cancer, enhancing patient outcomes.

How similar studies have gone: Other studies have shown success in similar approaches to understanding thyroid cancer, but this study also incorporates novel techniques and methodologies.

Who can join: the full rules

Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male or female, adults or children \>= 6 months+.
2. Patients with known or suspected thyroid nodules and/or thyroid cancer.
3. At risk family members of patients who have a genetic susceptibility to developing thyroid cancer.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1\. Serious underlying medical conditions that restrict diagnostic testing or therapy such as renal failure, congestive cardiac failure or active coexisting non-thyroid carcinoma requiring intervention before thyroid cancer is addressed.

Where it's running

  • National Institutes of Health Clinical Center
    Bethesda, Maryland, United States
    Recruiting

Study contacts

  • Principal investigator: Joanna Klubo-Gwiezdzinska, M.D. — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • Study coordinator: Padmasree Veeraraghavan, R.N.
  • Email: padmasree.veeraraghavan@nih.gov
  • Phone: (301) 451-7710

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.