Understanding thyroid tumors and their treatment
Official title: Studies on Thyroid Nodules and Thyroid Cancer
Run by National Institutes of Health Clinical Center (CC) · NCT00001160 · Data updated 2026-11-12
This study is trying to learn more about thyroid nodules and cancer by looking at how well current treatments work and testing new ways to diagnose and treat these conditions in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Months to 98 Years |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | June 1, 1977 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT00001160 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults and children aged 6 months and older with known or suspected thyroid nodules or thyroid cancer.
✕Probably not a fit
Patients with serious underlying medical conditions that limit diagnostic testing or therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients diagnosed with or suspected to have thyroid nodules or thyroid cancer. It aims to enhance the understanding of diagnostic and treatment methods for thyroid conditions by utilizing standard medical care alongside new techniques. Participants will undergo various diagnostic procedures, including imaging and biopsies, while blood and tissue samples will be collected for research purposes. The study will also evaluate the effectiveness of radioiodine therapy and the significance of serum thyroglobulin measurements in diagnosing tumor recurrence.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for thyroid cancer, enhancing patient outcomes.
How similar studies have gone: Other studies have shown success in similar approaches to understanding thyroid cancer, but this study also incorporates novel techniques and methodologies.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Male or female, adults or children \>= 6 months+. 2. Patients with known or suspected thyroid nodules and/or thyroid cancer. 3. At risk family members of patients who have a genetic susceptibility to developing thyroid cancer. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1\. Serious underlying medical conditions that restrict diagnostic testing or therapy such as renal failure, congestive cardiac failure or active coexisting non-thyroid carcinoma requiring intervention before thyroid cancer is addressed.
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Joanna Klubo-Gwiezdzinska, M.D. — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Study coordinator: Padmasree Veeraraghavan, R.N.
- Email: padmasree.veeraraghavan@nih.gov
- Phone: (301) 451-7710
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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MRG003 added to ongoing treatment after progression in EGFR-positive advanced thyroid cancer
In this study, researchers test whether adding MRG003 to a patient’s current thyroid cancer treatment can shrink tumors for those whose cancer initially responded but later progressed.
-
Selective coverage radiotherapy vs. full coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer
This trial tests whether covering only the tumor-affected area with radiation is as effective as full-area coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer, while aiming to reduce side effects and improve quality of life.
-
Trop-2 Targeted PET/CT for Recurrent and Metastatic Thyroid Cancer
This study tests whether a Trop-2 targeted PET/CT scan can better detect recurrent or metastatic thyroid cancer in adults than another PET/CT scan (FAPI).
-
WeChat-supported neck exercises after thyroidectomy
A telehealth program using a WeChat mini program tests if guided neck exercises after thyroid surgery help early recovery and quality of life.
-
Pralsetinib Drug Interaction Study in RET Fusion/MUTATION Positive Solid Tumors
This trial tests whether pralsetinib changes how the body processes certain medicines in adults with RET fusion- or mutation-positive advanced solid tumors.
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AI chatbot to guide thyroid cancer patients through perioperative education
A new AI chatbot is being tested to see if it helps thyroid cancer patients better prepare for discharge, recover well, and stay engaged in their care compared with traditional education.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.