Condition

Sarcoma clinical trials and research

• 112Clinical trials
• 150NIH research projects
• 17Countries

Newest Sarcoma clinical trials

All recruiting trials (112)

• MIGHTY: CAR T cells targeting B7-H3 for pediatric, teen, and young adult sarcoma

  This Phase 1 trial tests autologous hBRCA84D CAR T cells in kids, teens, and young adults (1–24) with relapsed or refractory RMS, ES, or DSRCT to see if the therapy is feasible and safe.

  Recruiting at 2 sites Phase 1 University College, London · London and 1 other locations · NCT07751380

• Lifileucel (Tumor-infiltrating lymphocytes) for advanced soft tissue sarcoma

  This study tests lifileucel, a cell therapy made from a patient’s own tumor cells, in adults with unresectable or metastatic soft tissue sarcoma who have had prior treatments to see if it helps shrink tumors and improve outcomes.

  Recruiting at 2 sites Phase 2 Iovance Biotherapeutics, Inc. · Tampa, Florida and 1 other locations · NCT07741877

• Domatinostat with Sirolimus for relapsed or refractory sarcoma and osteosarcoma

  This study tests whether the cancer drugs domatinostat and sirolimus together can help adolescents and adults whose sarcoma or osteosarcoma has come back or stopped responding to standard therapy.

  Recruiting at 2 sites Phase 1/2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 3 other locations · NCT07725380

• Clonal Hematopoiesis Effects with Chemo and Radiation in Solid Cancers

  This study tests whether clonal hematopoiesis affects outcomes for adults with solid cancers who are receiving chemotherapy or radiation.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07675967

• AYA Sarcoma Survivors: Personalized Exercise Program Pilot

  This pilot tests a personalized 12-week exercise program for adolescents and young adults with sarcoma to see if a triage tool can connect them with the right rehabilitation and exercise services.

  Recruiting at 3 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT07662239

• Fluorescence-guided surgery to reduce unexpected positive margins in high-grade sarcoma

  This phase II trial tests whether adding fluorescence-guided surgery with indocyanine green can lower unexpected positive margins in patients with high-grade sarcoma compared to standard surgery.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT07650656

• Hypnosis to help adolescents and young adults cope with cancer and chemotherapy

  This study tests whether hypnosis can reduce anxiety and chemotherapy-related symptoms in young people with sarcoma, germ cell tumors, or breast cancer.

  Recruiting Institut Bergonié · Bordeaux · NCT07614620

• Risvutatug Rezetecan in advanced sarcoma: a first-in-cohort study for adolescents and adults

  This study tests Risvutatug Rezetecan (Ris-Rez) to see if it can help people with unresectable, advanced osteosarcoma or soft tissue sarcoma who have already received treatment.

  Recruiting at 13 sites Phase 1/2 GlaxoSmithKline · West Valley City, Utah and 12 other locations · NCT07602777

• LRRC15-targeted PET imaging for more precise diagnosis and staging of pancreatic, breast, lung, sarcoma and head-and-neck cancers

  This project tests whether an LRRC15-targeted PET scan can better detect and stage LRRC15-expressing cancers and measures how the tracer behaves in healthy adults.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07552467

• Preoperative spatially fractionated radiation for large limb and trunk soft tissue sarcoma

  This trial tests whether a short, five-fraction course of spatially fractionated radiation given before surgery helps adults with large (≥5 cm) limb or trunk soft tissue sarcoma stay disease-free longer.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501026

• Safety and dosing of 177Lu-INN805 in patients with malignant solid tumors

  This early-phase, single-arm study tests different dose levels of 177Lu-INN805 to see if it can be safely given and if it shows signs of activity in adults with hard-to-treat solid tumors.

  Recruiting Early Phase 1 FindCure Biosciences (ZhongShan) Co., Ltd. · Wuxi, Jiangsu · NCT07459283

• Riluzole to prevent thinking and memory problems during chemotherapy

  This pilot trial tests whether riluzole can prevent thinking and memory problems in adults with cancer receiving anthracycline- or platinum-based chemotherapy.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07447050

• Personalised neoadjuvant therapy planning for adults with high‑risk soft tissue sarcoma

  This project tests whether analyzing tumor tissue and clinical data can help guide neoadjuvant chemotherapy decisions for adults with high‑risk soft tissue sarcomas.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07432932

• EBNK-001 allogeneic NK cell therapy with low-dose IL-15, with or without pembrolizumab, for advanced solid tumors

  This treatment tests an off-the-shelf NK cell product (EBNK-001) given with low-dose IL-15, either alone or with pembrolizumab, in adults with advanced or metastatic solid tumors who have exhausted standard options.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07410676

• Navigation program for young cancer survivors

  This project tests an adapted navigation program to help adolescent and young adult cancer survivors get timely care within Kaiser Permanente Southern California.

  Recruiting Kaiser Permanente · Pasadena, California · NCT07406087

• Pain patterns and opioid use in adolescent and young adult sarcoma survivors

  This project tests whether a 3-month smartphone-based daily survey can work for adolescents and young adult sarcoma survivors who have ongoing pain or use opioids.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07402577

• Multimodal exercise to support chemotherapy for newly diagnosed pediatric and AYA sarcoma patients

  This trial will test whether a tailored exercise program helps newly diagnosed pediatric and AYA sarcoma patients start and stay on their planned chemotherapy.

  Recruiting University of Miami · Miami, Florida · NCT07359911

• Paclitaxel polymer micelles with gemcitabine and targeted drugs for advanced sarcoma

  This Phase 2 study tests whether combining a new paclitaxel formulation with gemcitabine and a targeted drug can help people with advanced or metastatic bone or soft tissue sarcoma that progressed after first-line chemotherapy.

  Recruiting Phase 2 Shanghai 6th People's Hospital · Shanghai, CH · NCT07359053

• PROMIS questionnaires and smartphone mobility tracking after sarcoma surgery

  This project tests whether PROMIS questionnaires together with a new smartphone app can track recovery and mobility in adults undergoing surgery for sarcoma or giant cell tumor of bone.

  Recruiting at 2 sites University of Calgary · Phoenix, Arizona and 3 other locations · NCT07227961

• Hypofractionated radiation plus B7-H3 CAR T cells for children and young adults with relapsed sarcoma

  This will test whether short-course radiation given before B7-H3 CAR T-cell therapy is safe for children and young adults (≤21) with relapsed or refractory B7-H3–positive sarcomas.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07222735

• Zanidatamab for solid tumors with HER2 changes

  This study will try zanidatamab, an anti-HER2 drug, in adults with advanced endometrial, colorectal, head and neck, sarcoma, or non-small cell lung cancer whose tumors have specific HER2 changes.

  Recruiting at 2 sites Phase 2 Unicancer · Angers and 3 other locations · NCT07192068

• 177Lu-BetaBart treatment for relapsed, inoperable, or metastatic solid tumors

  This trial will test a radioactive antibody called 177Lu-BetaBart in adults whose solid tumors have progressed after prior treatment, including castration-resistant prostate, colorectal, lung, ovarian, or cervical cancer.

  Recruiting at 5 sites Phase 1/2 Radiopharm Theranostics, Ltd · Dothan, Alabama and 4 other locations · NCT07189871

• Quality of life and medical care for long-term sarcoma survivors in Germany (PROSa+)

  This project will ask adults in Germany who were diagnosed with sarcoma at least five years ago to complete questionnaires and some interviews to see how cancer and its treatments affect their quality of life and medical care.

  Recruiting at 4 sites Technische Universität Dresden · Dresden, Saxony and 4 other locations · NCT07148193

• Fluorescence-guided surgery to optimize sarcoma margins

  This will try using an injected fluorescent dye (ICG) during surgery to see if it reduces positive margins and reoperations for adults having curative surgery for intermediate-to-high grade soft tissue sarcoma of the trunk or limbs.

  Recruiting at 2 sites University of Aarhus · Aarhus N and 1 other locations · NCT07134192

• Registry of pediatric proton and photon radiation therapy

  This registry will collect detailed 3D radiation dose data and health outcomes from children and young adults treated with proton or photon therapy to see how treatment type relates to long-term side effects and quality of life.

  Recruiting at 2 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT07129317

• Weekly low-dose doxorubicin for older adults with advanced leiomyosarcoma

  This trial will test whether giving doxorubicin at a lower dose once a week helps people aged 65–100 with advanced or metastatic leiomyosarcoma keep their cancer from getting worse.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT07125183

• Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors

  This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.

  Recruiting at 18 sites AstraZeneca · Birmingham, Alabama and 17 other locations · NCT07124000

• Making MDT meetings more effective and safer with Salutare One Referral software

  This project will try the Salutare One Referral software with NHS MDT members and coordinators to see if it speeds up meetings and improves the information used for treating solid tumors and sarcoma.

  Recruiting Salutare Group Ltd. · London · NCT07104955

• Pembrolizumab for ultra-rare sarcomas

  This trial will test whether pembrolizumab can help people with certain ultra-rare sarcomas and cause only mild side effects.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07089992

• Short-course radiotherapy before surgery for soft tissue sarcoma

  This study tests whether a shorter course of radiation given before surgery (a 14 x 3 Gy schedule or an even shorter regimen) works as well and is safe for adults with intermediate- to high-grade soft tissue sarcoma.

  Recruiting at 2 sites The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT07071727

• Sequential CD146- and HER2-targeted CAR T-cell therapy for advanced sarcoma

  This treatment will test whether giving a patient's own CAR T cells that target CD146 and HER2, one after the other, can shrink tumors in children and adults with relapsed or refractory advanced sarcoma.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07066982

• Virtual exercise program to preserve function and prevent disability during chemotherapy

  This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

  Recruiting at 29 sites Alliance for Clinical Trials in Oncology · Dublin, California and 29 other locations · NCT07059884

• Wearable AI to monitor heart function after lymphoma or sarcoma treatment

  This project will test whether a smartwatch-based AI ECG combined with periodic echocardiograms can find early heart damage in lymphoma or sarcoma survivors treated with anthracycline chemotherapy.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07058064

• ABSK043, an oral PD-L1 inhibitor for angiogenic sarcomas

  This trial will test whether the oral PD-L1 drug ABSK043 can help adults with advanced angiogenic sarcomas that cannot be removed or have spread.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07014137

• Combining STC-15 with Toripalimab for Advanced Cancers

  This study is testing whether combining a new cancer drug, STC-15, with toripalimab can help people with advanced cancers feel better and improve their treatment outcomes.

  Recruiting at 11 sites Phase 1/2 STORM Therapeutics LTD · San Francisco, California and 13 other locations · NCT06975293

• Liquid biopsy (ctDNA) blood test for bone and soft tissue sarcoma

  This study will test whether low-pass whole genome sequencing of a blood liquid biopsy can detect tumor DNA in adults and children with bone or soft tissue sarcomas.

  Recruiting at 2 sites Wake Forest University Health Sciences · Charlotte, North Carolina and 1 other locations · NCT06958107

• Super1 TCR-T for NY-ESO-1–positive advanced solid tumors

  This trial tests whether a single infusion of Super1 TCR-T can help people with advanced sarcoma, lung cancer, or melanoma whose tumors are HLA-A*02 positive and express NY-ESO-1.

  Recruiting Phase 1 Guangzhou FineImmune Biotechnology Co., LTD. · Guangzhou, Gaungdong · NCT06942143

• Preventing wound complications after limb sarcoma surgery with a single-use negative-pressure dressing

  This test will try a single-use negative-pressure wound dressing (PICO14) to see if it reduces wound complications after limb high-grade soft tissue sarcoma surgery in adults who received preoperative radiotherapy.

  Recruiting Istituto Oncologico Veneto IRCCS · Padova, Italy/Padova · NCT06941194

• IDOV-Immune for advanced solid tumors

  This trial will try a single IV infusion of an engineered oncolytic vaccinia virus called IDOV-Immune in adults with advanced solid tumors that no longer respond to standard treatments.

  Recruiting at 5 sites Phase 1 ViroMissile, Inc. · St Louis, Missouri and 4 other locations · NCT06910657

• Using modified T cells to treat advanced melanoma and sarcoma

  This study is testing a new treatment that uses modified T-cells to see if it can help people with advanced melanoma and sarcoma fight their cancer better.

  Recruiting Phase 1 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud and 1 other locations · NCT06889766

• Educational videos for people newly diagnosed with sarcoma

  This project will test whether watching four short sarcoma-specific videos before the first oncology visit helps newly diagnosed adults (or their caregivers) better understand the disease and treatment options.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT06805773

• Early palliative care for patients with advanced sarcoma

  This study tests if adding early palliative care to standard treatment can improve the quality of life for people with advanced soft tissue sarcoma.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT06805669

• Investigating OKN4395 and Pembrolizumab for Solid Tumors

  This study is testing a new drug called OKN4395, alone and with another drug called pembrolizumab, to see if it can help people with solid tumors who have run out of other treatment options.

  Recruiting at 10 sites Phase 1 Epkin · Beverly Hills, California and 9 other locations · NCT06789172

• Targeted therapy using Lead-212 for solid tumors

  This study is testing a new targeted radiation treatment for patients with solid tumors that have a specific protein to see if it can effectively treat their cancer while protecting healthy tissue.

  Recruiting at 16 sites Phase 1/2 Perspective Therapeutics · Los Angeles, California and 15 other locations · NCT06710756

• Testing a new drug combination for treating relapsed or refractory sarcomas in adolescents and young adults

  This study is testing a new combination of drugs to see if it can help adolescents and young adults with tough-to-treat sarcomas feel better and improve their chances of recovery.

  Recruiting Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT06709495

• Using Ivocizumab to treat various advanced rare tumors

  This study is testing if a new treatment called Ivocizumab can help people with different types of advanced rare tumors feel better and live longer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06683846

• Understanding recovery in children after cancer surgery

  This study looks at how children aged 3-18 and their families recover after cancer surgery by using smartwatches and surveys to gather information over a year.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06674811

• Testing DS-2243a for advanced solid tumors

  This study is testing a new treatment called DS-2243a to see if it helps people with advanced solid tumors like certain types of sarcoma, lung cancer, and bladder cancer.

  Recruiting at 7 sites Phase 1 Daiichi Sankyo · Boston, Massachusetts and 6 other locations · NCT06644755

• Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues

  This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06580002

• All-trans retinoic acid (ATRA) plus cemiplimab for advanced leiomyosarcoma

  This trial will try combining oral all-trans retinoic acid with the immunotherapy cemiplimab to see if it can shrink tumors or slow progression in adults with metastatic or unresectable leiomyosarcoma after standard chemotherapy.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06528769

• Injecting a virus directly into tumors to treat advanced cancers

  This study is testing whether injecting a special virus directly into tumors can be safe and help people with advanced solid cancers.

  Recruiting Phase 1 GONGCHU Biotechnology Co., Ltd · Zhengzhou, Henan · NCT06508307

• Using a new imaging agent to detect various cancers

  This study is testing a new imaging agent to see if it can better detect certain cancers in adults compared to standard imaging methods.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06503146

• Using modified T cells to treat certain solid tumors in children and young adults

  This study is testing a new treatment using modified T cells to see if it can help children and young adults with tough-to-treat solid tumors.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT06500819

• Understanding the long-term effects of sarcoma on survivors

  This study is trying to understand how surviving sarcoma affects people's health and wellbeing over time by looking at their activity levels, health data, and personal experiences.

  Recruiting Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT06482957

• Helping adolescent and young adult cancer survivors manage symptoms and stay engaged in post-treatment care

  This trial will test whether AYA STEPS, a six-session digital program, can help adolescent and young adult cancer survivors reduce symptoms and keep up with recommended follow-up care.

  Recruiting Duke University · Durham, North Carolina · NCT06371768

• Using 64Cu-LNTH-1363S for imaging in patients with sarcoma or gastrointestinal cancers

  This study is testing a new imaging agent called 64Cu-LNTH-1363S in patients with metastatic sarcoma or gastrointestinal cancers to see how safe it is and how well it works for imaging their tumors.

  Recruiting at 5 sites Phase 1/2 Lantheus Medical Imaging · Duarte, California and 4 other locations · NCT06298916

• Evaluating comprehensive molecular testing for advanced cancer patients

  This study is testing whether a new genetic test can help doctors choose better treatments for patients with advanced cancers like breast cancer and melanoma.

  Recruiting at 7 sites BostonGene · Rogers, Arkansas and 6 other locations · NCT06272864

• Testing MGC026 in patients with advanced solid tumors

  This study is testing a new treatment called MGC026 to see if it can help adults with advanced solid tumors that can't be removed or have spread to other parts of the body.

  Recruiting at 12 sites Phase 1 MacroGenics · Los Angeles, California and 11 other locations · NCT06242470

• Digital peer support for young adults with cancer

  This study is testing a digital support program to see if it can help young adults who have finished cancer treatment by connecting them with trained peers for guidance and encouragement.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06193369

• Assessing early psychiatric referral effects on mental health in sarcoma patients

  This study tests whether getting early mental health support helps sarcoma patients feel less anxious and depressed while recovering from surgery.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06129903

• Treatment of advanced bone and soft tissue sarcoma with VG161 injections

  This study is testing if VG161 injections can help people with advanced bone and soft tissue sarcoma who haven't responded to other treatments.

  Recruiting Phase 2 CNBG-Virogin Biotech (Shanghai) Ltd. · Beijing · NCT06126510

• Using palbociclib and pembrolizumab for treating undifferentiated pleomorphic sarcoma

  This study is testing if a combination of two drugs, palbociclib and pembrolizumab, can help improve treatment for people with undifferentiated pleomorphic sarcoma by looking at changes in their tumors after a few weeks.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT06113809

• Combining local ablative therapy with ongoing systemic treatment for certain cancers

  This study is testing whether adding local treatments to ongoing cancer therapy can help people with certain solid tumors live longer without their disease getting worse.

  Recruiting University of California, Davis · Sacramento, California · NCT06103669

• Combining PARP inhibitors, immunotherapy, and targeted radiation for advanced sarcoma

  This study is testing a new treatment that combines two drugs and targeted radiation to see if it can help people with advanced bone and soft tissue sarcomas feel better and improve their outcomes.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06074692

• GRID therapy for treating extremity soft tissue sarcoma

  This study is testing a new type of radiation therapy called GRID to see if it can safely help people with high-risk soft tissue sarcoma before they have surgery.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06073067

• Testing a new drug called CRD3874-SI for solid tumors

  This study is testing a new drug called CRD3874-SI to see if it is safe and what the best dose is for people with advanced solid tumors like sarcoma and Merkel Cell Carcinoma.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06021626

• New bispecific antibody treatment for colorectal cancer

  This study is testing a new antibody treatment for people with advanced colorectal cancer who haven't had success with other therapies to see if it can help their immune system fight the cancer better.

  Recruiting Phase 1 German Cancer Research Center · Tübingen, Baden-Wurttemberg · NCT05999396

• Evaluating HTL0039732 for Advanced Solid Tumours

  This study is testing a new drug called HTL0039732, alone and with another treatment, to see if it can help people with advanced solid tumors by boosting their immune response against cancer.

  Recruiting at 6 sites Phase 1/2 Cancer Research UK · Cambridge and 5 other locations · NCT05944237

• Creating immune organoids to study pediatric cancers

  This study is trying to create mini immune systems from kids' tissues to see how they respond to different types of pediatric cancers.

  Recruiting at 2 sites Gustave Roussy, Cancer Campus, Grand Paris · Villejuif and 1 other locations · NCT05890781

• Investigating cognitive impairment in young cancer patients during and after chemotherapy

  This study is testing how chemotherapy affects memory and attention in children and young adults with cancer to better understand their cognitive challenges during and after treatment.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05840575

• Comparing two radiation therapy techniques for advanced solid tumors

  This study is testing whether a new type of radiation therapy works better than the standard method for treating advanced solid tumors that have spread, to see if it can improve outcomes for patients needing palliative care.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05837767

• HS-20093 treatment for patients with relapsed or refractory osteosarcoma and other sarcomas

  This study is testing a new treatment called HS-20093 to see if it can help patients with relapsed or hard-to-treat osteosarcoma and other types of sarcomas feel better.

  Recruiting at 11 sites Phase 2 Hansoh BioMedical R&D Company · Beijing and 10 other locations · NCT05830123

• Monitoring disease outcomes and side effects in patients with gastrointestinal cancers and sarcomas

  This study is trying to see how standard treatments for gastrointestinal cancers and sarcomas affect patients' health and side effects over time.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT05743426

• Treatment for lung cancer using targeted chemotherapy delivery

  This study is testing a new way to deliver chemotherapy directly to lung tumors in patients with hard-to-treat lung cancer to see if it helps control tumor growth better than standard treatments.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT05672108

• Exploring a new cancer treatment using PeptiCRAd-1 and checkpoint inhibitors

  This study is testing a new cancer treatment that combines a special virus with immune therapy to see if it can help people with advanced cancer who haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Valo Therapeutics Oy · Frankfurt and 6 other locations · NCT05492682

• Observational study on bone and soft tissue sarcoma in the Netherlands

  This study is collecting health information and experiences from people in the Netherlands who have bone or soft tissue sarcoma to help improve their treatment and care.

  Recruiting at 2 sites Radboud University Medical Center · Arnhem and 1 other locations · NCT05373810

• Validation of a blood test for early cancer detection and monitoring

  This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.

  Recruiting at 3 sites Adela, Inc · Duarte, California and 16 other locations · NCT05366881

• Selumetinib plus ZEN-3694 with durvalumab for certain sarcomas and NF1-associated MPNST

  This trial tests a combination of medicines to see if they can help adults with unresectable or metastatic sarcomas, including NF1-associated MPNST.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05253131

• Testing if lab drug screening can predict cancer treatment responses

  This study is testing if a new way of checking how tumors respond to different cancer treatments can help doctors choose the best options for patients with solid tumors like bladder or kidney cancer.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT05231655

• Combination therapy using checkpoint inhibitors for advanced solid tumors

  This study is testing a new combination treatment using special antibodies for people with advanced solid tumors like lung and liver cancer to see if it can be safer and more effective than current options.

  Recruiting Phase 1/2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05187338

• Using cabozantinib to prevent recurrence in high-risk pediatric solid tumors

  This study is testing if the drug cabozantinib can help prevent high-risk pediatric solid tumors, like neuroblastoma and sarcoma, from coming back after treatment.

  Recruiting at 6 sites Phase 2 Nationwide Children's Hospital · Birmingham, Alabama and 5 other locations · NCT05135975

• Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma

  This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04995003

• Predicting treatment for sarcomas and melanomas using patient-derived models

  This study is trying to see if creating models from tumor samples can help find the best drug combinations for patients with sarcomas and melanomas after their usual treatments haven't worked.

  Recruiting National Cancer Centre, Singapore · Singapore · NCT04986748

• A project to collect and analyze data on sarcoma patients

  This study is collecting and analyzing information from sarcoma patients to help improve understanding and treatment of this type of cancer.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT04758325

• Using fluorescent dye to improve tumor margin examination during sarcoma surgery

  This study is testing if a special dye can help surgeons see tumor edges better during sarcoma surgery to make sure they remove all the cancerous tissue.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT04719156

• Combining Retifanlimab with chemotherapy for advanced soft tissue sarcoma

  This study is testing if adding Retifanlimab to chemotherapy can help people with advanced soft tissue sarcoma fight their cancer better than the usual treatments.

  Recruiting Phase 1/2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT04577014

• Pre-operative rehabilitation for patients with limb sarcoma

  This study is testing a pre-surgery rehab program to see if it helps people with limb sarcoma recover better and regain their independence after surgery.

  Recruiting Phase 2 Institut Claudius Regaud · Toulouse · NCT04515459

• Using stereotactic body radiotherapy for patients with rare oligometastatic cancers

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.

  Recruiting at 13 sites European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht and 12 other locations · NCT04498767

• Improving recovery after surgery for extremity sarcoma

  This study is testing a new recovery plan for people having surgery for extremity sarcoma to see if it helps them manage pain better and recover faster without using narcotics.

  Recruiting Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT04461171

• Creating a database for sarcoma research

  This study is creating a database to collect blood and tissue samples from people with liposarcoma to help researchers learn more about the disease and find new treatments.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier, Herault · NCT04458792

• Treatment of advanced solid tumors with T3011 and pembrolizumab

  This study is testing a new treatment called T3011, given as an injection, alone and with another drug called pembrolizumab, to see if it helps people with advanced solid tumors like melanoma and head and neck cancer.

  Recruiting at 8 sites Phase 1/2 ImmVira Pharma Co. Ltd · Gilbert, Arizona and 8 other locations · NCT04370587

• Using blood tests to assess early treatment response in cancer patients

  This study is testing if blood tests that look for cancer DNA can help doctors see how well treatment is working for patients with different types of solid tumors.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT04354064

• Combining pembrolizumab with local chemotherapy for sarcoma treatment in limbs

  This study is testing if combining an immunotherapy drug with local chemotherapy can help people with advanced sarcoma in their limbs live longer without their disease getting worse.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT04332874

• Developing a prediction model for selecting patients with sarcoma

  This study is trying to create a model that helps doctors choose the best treatment options for people with sarcoma based on their individual characteristics and tumor types.

  Recruiting at 8 sites Kantonsspital Winterthur KSW · Winterthur, Canton of Zurich and 7 other locations · NCT04300257

• Effects of Atezolizumab on Cancer Patients with Sensitive Tumor DNA or RNA

  This study is testing if atezolizumab can help cancer patients with certain tumor types that show they might respond well to the treatment.

  Recruiting Phase 2 British Columbia Cancer Agency · Vancouver, British Columbia and 1 other locations · NCT04273061

• Using MRI scans to monitor cancer treatment response during radiation therapy

  This study is testing if regular MRI scans can help doctors see how well radiation therapy is working for patients with advanced cancers like glioblastoma and esophageal cancer.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04188535

• Registry for patients with sarcoma and carcinosarcoma in Germany

  This study is gathering information from patients with sarcoma and carcinosarcoma in Germany to better understand their treatments and improve care for these rare tumors.

  Recruiting at 21 sites Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Tübingen, Baden-Wurttemberg and 20 other locations · NCT04122872

• Using Apatinib to treat advanced or metastatic sarcoma with a specific genetic marker

  This study is testing if the drug Apatinib can help people with advanced bone and soft tissue sarcoma who have a specific genetic marker feel better and have fewer side effects.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT04072042

• Analysis of blood tumor markers for cancer diagnosis and treatment monitoring

  This study is testing whether a simple blood test can replace traditional tissue biopsies to help diagnose cancer and monitor how well treatments are working.

  Recruiting at 2 sites Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier and 1 other locations · NCT04025541

• National database for sarcoma patients in France

  This study is creating a national database to help doctors understand how to better treat sarcoma patients in France by tracking their care and outcomes over time.

  Recruiting at 3 sites Institut Bergonié · Bordeaux and 2 other locations · NCT03978039

• Combination therapy for advanced sarcoma using three different treatments

  This study is testing a combination of three treatments for advanced sarcoma to see if they can help patients live longer without their cancer getting worse.

  Recruiting Phase 2 Sarcoma Oncology Research Center, LLC · Santa Monica, California · NCT03886311

• Stereotactic Body Radiation Therapy with Immunotherapy for Oligometastatic Sarcoma

  This study is testing if combining a special type of radiation therapy with an immunotherapy drug can help people with oligometastatic soft tissue sarcoma live longer and feel better compared to just using radiation alone.

  Recruiting at 4 sites Phase 2 Centre Antoine Lacassagne · Bordeaux and 16 other locations · NCT03548428

• Using Nivolumab after Half-Matched Bone Marrow Transplant for Sarcoma

  This study is testing if a new drug called Nivolumab can help prevent or delay the return of high-risk sarcomas in children and adults after they receive a special type of bone marrow transplant.

  Recruiting at 3 sites Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · St. Petersburg, Florida and 3 other locations · NCT03465592

• Creating a database for cancer research and treatment

  This study is creating a detailed database to help researchers understand different types of cancer better and improve treatments for patients.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier · NCT03449264

• Evaluating the best methods for reattaching hip muscles after femur replacement

  This study is testing different ways to reattach hip muscles after femur replacement surgery to see if one method helps patients recover better than others.

  Recruiting Duke University · Durham, North Carolina · NCT03261544

• Biobanking study to understand cancer and immune response

  This study is collecting tumor and blood samples from cancer patients to see how their tumors and immune responses change during treatment.

  Recruiting at 5 sites Institut Curie · Bordeaux and 5 other locations · NCT03017573

• Testing TURALIO(R) for treating hard-to-treat cancers in young people

  This study is testing if TURALIO(R) can safely help children and young adults with tough-to-treat cancers by seeing how well it works to shrink tumors or stop them from growing.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02390752

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Molecular testing for personalized cancer therapy at MD Anderson

  This study is testing if looking at the genetic makeup of tumors in cancer patients can help find the best personalized treatments and match them with suitable clinical trials.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT01772771

• Collecting and storing samples from children and adults with common childhood cancers

  This study is collecting and storing samples from children and adults with common childhood cancers to help researchers learn more about these diseases and find better treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 4 other locations · NCT01109394

• Investigating biochemical and molecular factors in soft tissue sarcoma

  This study is trying to find out if certain markers in tissue and blood samples from patients with soft tissue sarcoma can help predict how well they will respond to treatment.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT00579566

• Collecting specimens and data for early detection and prevention of ovarian cancer

  This study is trying to find better ways to detect and prevent ovarian cancer early by collecting blood and tissue samples from people at high risk.

  Recruiting Northwestern University · Chicago, Illinois · NCT00005095

NIH-funded research (newest 40 of 150)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Testing new therapies for pediatric and young adult sarcoma, kidney, and liver cancers

  Researchers are testing new drugs and smart combinations in models of pediatric cancers to help guide future treatments for kids and young adults.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11538882

• Precision 3D Imaging to Monitor Kaposi Sarcoma (KS) with SkinScan3D

  A new portable 3D imaging tool called SkinScan3D will help doctors measure KS skin lesions more accurately and quickly, especially in people living with HIV.

  NIH research Washington University · Saint Louis, United States · NIH-11535366

• Precision 3D Imaging to Track Kaposi Sarcoma (KS) with SkinScan3D

  A new 3D imaging tool called SkinScan3D helps doctors monitor Kaposi sarcoma lesions more accurately and quickly, especially in settings with high KS burden like East Africa and in U.S. clinics with HIV patients.

  NIH research Washington University · Saint Louis, United States · NIH-11535365

• Rapid, bedside KS diagnosis in Africa with KS-COMPLETE

  A fast, point-of-care test using skin biopsies to diagnose Kaposi’s sarcoma in sub-Saharan Africa, helping patients get results in about an hour.

  NIH research Cornell University · Ithaca, United States · NIH-11535338

• Kaposi Sarcoma care and research in Africa during ART era

  A collaborative program to better understand and improve diagnosis, treatment, and prevention of Kaposi sarcoma for people living with HIV in Zambia and Tanzania.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11535231

• Kaposi Sarcoma in Africa: ART Era Research Network

  A collaborative program in Africa and the United States will study Kaposi sarcoma in people living with HIV on ART to improve diagnosis, treatment, and prevention.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11535230

• Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors

  A program uses mouse tumor models to identify promising drug candidates for children with sarcoma and other solid tumors.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11534528

• Improving outcomes for sarcoma patients through subtype-specific NCI trials

  A Mayo Clinic-led effort to run and complete targeted sarcoma clinical trials that focus on specific histologic subtypes to better tailor treatment for patients.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11447867

• Multimodal approach to understand CIC::DUX4 sarcoma in mice

  A study using mouse models of CIC::DUX4 sarcoma to uncover how this aggressive cancer starts, grows, and responds to treatments.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11447311

• AI-powered prognostic model for Ewing sarcoma using digital pathology

  Researchers are building an AI tool to predict survival for children and adults with Ewing sarcoma using digitized pathology slides.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11440620

• RAPID: A patient-centered, fast-tracked drug trial platform for young people with relapsed Ewing sarcoma and DSRCT

  A patient-friendly, open-label phase 2 platform trial tests promising drug combinations for teens and young adults whose Ewing sarcoma or DSRCT has come back or not responded to treatment.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11440318

• B7-H3 fluorescent probe to guide sarcoma surgery

  A new B7-H3-targeted fluorescent probe is being developed to help surgeons see and remove all cancerous tissue during sarcoma operations.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11436823

• TGFβ brakes immune evasion and metastasis in Ewing sarcoma during radiation

  A physician-scientist will study whether blocking TGFβ during radiation can help CAR T cells fight Ewing sarcoma and improve patient outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11435865

• Targetable Epigenetic and Immuno-Oncologic Vulnerabilities in Synovial Sarcoma

  A cancer research project at Sloan Kettering aims to find epigenetic and immune vulnerabilities in synovial sarcoma to guide future treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11419133

• SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients

  A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11419123

• Kaposi Sarcoma in Africa in the ART Era

  This grant supports research to improve how Kaposi sarcoma is detected, treated, and understood in people living with HIV in Zambia and Tanzania during ART, with collaboration between African hospitals and a U.S. center.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11417959

• Faster detection and connection to care for people with HIV who develop Kaposi sarcoma in East Africa

  This project aims to speed up finding people with HIV diagnosed with Kaposi sarcoma in East Africa and help them get linked to care more quickly.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11416376

• Rapid case finding to connect people with HIV and Kaposi sarcoma to care in East Africa

  This project works to find people with HIV who develop Kaposi sarcoma more quickly and help them get into medical care sooner.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11416317

• Faster diagnosis and care for HIV-related Kaposi sarcoma in East Africa

  This project helps identify people with HIV who develop Kaposi sarcoma in East Africa and connects them quickly to medical care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11416275

• Kaposi sarcoma care and research in Zambia and Tanzania

  Researchers are working with hospitals in Zambia and Tanzania to improve how Kaposi sarcoma is found, treated, and understood for people living with HIV on antiretroviral therapy.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11412992

• Kaposi sarcoma care and research partnership in Zambia and Tanzania

  This program connects hospitals in Zambia, Tanzania, and the U.S. to improve how Kaposi sarcoma is found, treated, and understood in people living with HIV on antiretroviral therapy.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11412991

• Defining Key Vulnerable Targets to Prevent KSHV-Related Diseases

  Aiming to map the parts of the Kaposi sarcoma-associated herpesvirus (KSHV) that antibodies should target to block infection and disease, with samples from people living with HIV.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11411253

• Function and Targeting of ETV6 in Ewing Sarcoma

  A scientist at Case Western Reserve University is studying a specific protein, ETV6, that helps a rare bone cancer called Ewing sarcoma, with the goal of finding targeted therapies that could spare healthy cells.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11408636

• Precision 3D imaging to monitor Kaposi sarcoma (KS) with SkinScan3D

  A new portable 3D imaging tool uses AI to measure KS skin lesions more quickly and objectively, helping people withKS and their clinicians track treatment.

  NIH research Washington University · Saint Louis, United States · NIH-11402685

• How gut bacteria affect AIDS-related Kaposi’s sarcoma and its treatment

  This project looks at how the bacteria in the body may influence KS cancer risk and treatment outcomes in people with HIV/AIDS.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11401413

• 3D skin imaging for Kaposi sarcoma care

  This project will use a portable 3D imaging device with AI to measure Kaposi sarcoma skin lesions more accurately for people receiving treatment in East Africa.

  NIH research Washington University · Saint Louis, United States · NIH-11400582

• Precision 3D imaging to improve Kaposi sarcoma care

  A portable 3D camera with built-in AI will be used to measure Kaposi sarcoma skin lesions more precisely for people getting KS care in East Africa.

  NIH research Washington University · Saint Louis, United States · NIH-11400231

• Cohort study to understand sarcoma survivorship across life

  A large Vanderbilt-led project will follow about 2,100 people who survived sarcoma to learn how treatment, lifestyle, and biology affect long-term health and quality of life.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11397780

• MD Anderson Sarcoma SPORE: advanced immunotherapy and targeted treatments for sarcoma across ages

  A multi-institutional effort is testing immune-based and targeted therapies to reduce illness and death from sarcoma for patients of all ages.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11397753

• Targeting immune markers in Ewing Sarcoma to guide safer, more effective therapies

  A funded project at Stanford aims to use immune markers on Ewing Sarcoma to develop targeted immunotherapies that work in children and adults with this cancer.

  NIH research Stanford University · Stanford, United States · NIH-11396515

• Rapid, at-a-glance KS diagnosis in Africa using KS-COMPLETE

  A new, simple, point‑of‑care test will quickly diagnose Kaposi’s sarcoma from skin biopsies in sub-Saharan Africa to help people get faster treatment.

  NIH research Cornell University · Ithaca, United States · NIH-11391217

• Fast, point-of-care test for Kaposi's sarcoma in sub-Saharan Africa

  This will create a fast, easy skin-biopsy test that tells patients in sub-Saharan Africa whether they have Kaposi's sarcoma in about an hour.

  NIH research Cornell University · Ithaca, United States · NIH-11384056

• Ewing sarcoma: how DNA repair weaknesses affect risk and treatment

  A clinician-researcher team at Dana-Farber is studying how DNA damage repair weaknesses help drive Ewing sarcoma in kids and teens, with the goal of better predicting risk and guiding therapy.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11383129

• Novel OTUD7A inhibitors to treat Ewing sarcoma

  A scientist team is developing new small-molecule drugs that block OTUD7A to slow or stop Ewing sarcoma in children and young adults.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11381166

• Targeting transcription-driven cancer with small molecules

  A research project at UT Southwestern aims to create and test small drugs that jam the cancer-causing drive of fusion proteins in certain pediatric/adolescent cancers.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11370639

• Radiation-boosted treatment ideas for high-risk Ewing sarcoma with STAG2 loss

  A Mayo Clinic team is studying how combining radiation with new treatments may better help kids and teens with aggressive Ewing sarcoma that has lost STAG2.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11366203

• Targeting PAK4 in Ewing sarcoma to improve outcomes

  A new approach aims to block PAK4, a protein that helps Ewing sarcoma spread, to improve survival for patients with this pediatric bone cancer.

  NIH research Emory University · Atlanta, United States · NIH-11365885

• Understanding how USP1 helps Ewing sarcoma cells bypass replication stress

  Researchers are studying how a protein called USP1 lets Ewing sarcoma cells survive stress that would normally stop cancer growth.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362462

• Targeted therapies for HIV-related Kaposi sarcoma and lymphoma

  A patient-focused look at new targets and drug combinations to treat Kaposi sarcoma and AIDS-related lymphomas in people living with HIV.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11357655

• How transcription and RNA processing drive Ewing sarcoma

  Researchers are looking at how a fusion gene causes abnormal RNA transcription and splicing in Ewing sarcoma in children and young adults.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11330324

Related topics

Quick answers

How many Sarcoma clinical trials are recruiting right now?

112, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (64 trials), China (14 trials), France (13 trials), United Kingdom (9 trials), Canada (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 26, Phase 1: 16, Phase 1/2: 14, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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