Understanding genetic risks for thyroid cancer
Hereditary Risk Factors for Thyroid Cancer
This study is trying to find out if certain genes passed down in families can increase the risk of thyroid cancer by looking at the family and medical histories of people with thyroid cancer or nodules.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Sex | All |
| Sponsor | Dana-Farber Cancer Institute Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT02747888 on ClinicalTrials.gov |
What this trial studies
This research focuses on identifying hereditary risk factors for thyroid cancer by studying families with a history of the disease. Participants, including children and adults with known or suspected thyroid cancer or nodules, will provide family and medical history information along with blood or saliva samples for genetic analysis. The study aims to perform DNA sequencing to uncover genetic alterations that may contribute to thyroid cancer development. By understanding these genetic factors, researchers hope to improve risk assessment and management for affected families.
Who should consider this trial
Good fit: Ideal candidates include pediatric and adult patients with a history of thyroid cancer or nodules, particularly those from families with a strong suspicion of hereditary cancer.
Not a fit: Patients without a family history of thyroid cancer or those who do not have current or past thyroid cancer/nodules may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better screening and prevention strategies for individuals at risk of hereditary thyroid cancer.
How similar studies have performed: Other studies have shown success in identifying genetic factors associated with various cancers, suggesting that this approach may yield valuable insights into hereditary thyroid cancer.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).
* Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).
* Individuals from families with a high suspicion of hereditary thyroid cancer:
* Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (\<18 years old).
* Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include:
* Families with thyroid cancer in multiple individuals
* Families with thyroid cancer and a known genetic syndrome
* Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)
Exclusion Criteria:
* Individuals who are unable to give informed consent.
* Individuals who are unable to complete study materials.
Where this trial is running
Boston, Massachusetts
- Dana Farber Cancer Institute — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Junne Kamihara, MD, PhD — Dana-Farber Cancer Institute
- Study coordinator: Junne Kamihara, MD, PhD
- Email: junne_kamihara@dfci.harvard.edu
- Phone: 617.632.3044
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.