Understanding the genetics of thyroid cancer to improve diagnosis
Official title: Genetic architecture of thyroid cancer and its clinical utility
Funded at University of Colorado Denver · NIH-11061086 · Data updated 2026-11-12
This study is looking at the genes linked to thyroid cancer to help doctors better tell the difference between harmless and harmful thyroid nodules, which could mean fewer unnecessary biopsies and less worry for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $182,325 |
| NIH project number | 5R21CA282380-02 |
| Project ID | NIH-11061086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with thyroid nodules who are undergoing evaluation for potential thyroid cancer.
✕Less likely to help
Patients without thyroid nodules or those who have already been diagnosed with thyroid cancer may not benefit from this research.
What this research studies
This research investigates the genetic factors associated with thyroid cancer to enhance the risk assessment of thyroid nodules. By analyzing genetic data from thousands of patients, the study aims to develop a classifier that can better distinguish between benign and malignant nodules, potentially reducing unnecessary biopsies. Patients with thyroid nodules may benefit from improved diagnostic accuracy and reduced anxiety related to invasive procedures. The research employs advanced genetic analysis techniques, including genome-wide association studies (GWAS), to identify key biomarkers.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of thyroid nodules, reducing unnecessary biopsies and improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using genetic markers for cancer risk assessment, indicating potential success for this approach.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Pozdeyev, Nikita — University of Colorado Denver
- Study coordinator: Pozdeyev, Nikita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.