Investigating how environmental factors affect thyroid cancer
Official title: The Role of Environmental Factors in Thyroid Cancer
Run by Icahn School of Medicine at Mount Sinai · NCT05172921 · Data updated 2026-11-12
This study is trying to see how different environmental factors might influence the development and progression of thyroid cancer in adults who have been diagnosed with it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Icahn School of Medicine at Mount Sinai Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | February 3, 2022 |
| Main results expected | June 2030 |
| Study ends | June 2035 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT05172921 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with a Bethesda category III, IV, V, or VI thyroid nodule.
✕Probably not a fit
Patients with a history of thyroid cancer or those who are not surgical candidates will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the increasing incidence of thyroid cancer and the potential role of environmental risk factors in its etiology and progression. By utilizing exposomics, the study will analyze health-relevant chemical exposures and their metabolic impacts on individuals diagnosed with thyroid cancer. Participants will include adults aged 18 and older who have been categorized as Bethesda III, IV, V, or VI following Fine Needle Aspiration. The study will also collect data and samples from benign tumor patients for future research.
Why it matters
Potential benefit: If successful, this study could enhance understanding of environmental influences on thyroid cancer, potentially leading to improved prevention strategies.
How similar studies have gone: While the approach of studying environmental factors in thyroid cancer is gaining interest, this specific exposomics methodology is relatively novel and has not been extensively tested in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Bethesda category III, IV, V or VI following Fine Needle Aspiration; if a patient has a benign tumor following surgery, patient data/ samples will be stored to serve as benign control in potential future projects. * Age 18 years and older * Surgical candidate * Ability to provide informed consent Exclusion criteria: * History of thyroid cancer * Completion surgery candidate * Pregnant women or other vulnerable patients (e.g. wards of the state, prisoners)
Where it's running
-
Icahn School of Medicine at Mount Sinai
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Maaike van Gerwen, MD, PhD — Msh
- Study coordinator: Maaike van Gerwen, MD, PhD
- Email: maaike.vangerwen@mountsinai.org
- Phone: 2126599620
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
MRG003 added to ongoing treatment after progression in EGFR-positive advanced thyroid cancer
In this study, researchers test whether adding MRG003 to a patient’s current thyroid cancer treatment can shrink tumors for those whose cancer initially responded but later progressed.
-
Selective coverage radiotherapy vs. full coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer
This trial tests whether covering only the tumor-affected area with radiation is as effective as full-area coverage radiotherapy for poorly differentiated and anaplastic thyroid cancer, while aiming to reduce side effects and improve quality of life.
-
Trop-2 Targeted PET/CT for Recurrent and Metastatic Thyroid Cancer
This study tests whether a Trop-2 targeted PET/CT scan can better detect recurrent or metastatic thyroid cancer in adults than another PET/CT scan (FAPI).
-
WeChat-supported neck exercises after thyroidectomy
A telehealth program using a WeChat mini program tests if guided neck exercises after thyroid surgery help early recovery and quality of life.
-
Pralsetinib Drug Interaction Study in RET Fusion/MUTATION Positive Solid Tumors
This trial tests whether pralsetinib changes how the body processes certain medicines in adults with RET fusion- or mutation-positive advanced solid tumors.
-
AI chatbot to guide thyroid cancer patients through perioperative education
A new AI chatbot is being tested to see if it helps thyroid cancer patients better prepare for discharge, recover well, and stay engaged in their care compared with traditional education.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.