Clinical trial Recruiting at 1 site Observational Ages 18 and up

Investigating how environmental factors affect thyroid cancer

Official title: The Role of Environmental Factors in Thyroid Cancer

Run by Icahn School of Medicine at Mount Sinai · NCT05172921 · Data updated 2026-11-12

This study is trying to see how different environmental factors might influence the development and progression of thyroid cancer in adults who have been diagnosed with it.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorIcahn School of Medicine at Mount Sinai
Academic / other
Drugs / interventionsradiation
Locations1 site (New York, New York)
StatusRecruiting
StartedFebruary 3, 2022
Main results expectedJune 2030
Study endsJune 2035
Registry record updatedJune 17, 2026
Trial IDNCT05172921 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with a Bethesda category III, IV, V, or VI thyroid nodule.

Probably not a fit

Patients with a history of thyroid cancer or those who are not surgical candidates will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the increasing incidence of thyroid cancer and the potential role of environmental risk factors in its etiology and progression. By utilizing exposomics, the study will analyze health-relevant chemical exposures and their metabolic impacts on individuals diagnosed with thyroid cancer. Participants will include adults aged 18 and older who have been categorized as Bethesda III, IV, V, or VI following Fine Needle Aspiration. The study will also collect data and samples from benign tumor patients for future research.

Why it matters

Potential benefit: If successful, this study could enhance understanding of environmental influences on thyroid cancer, potentially leading to improved prevention strategies.

How similar studies have gone: While the approach of studying environmental factors in thyroid cancer is gaining interest, this specific exposomics methodology is relatively novel and has not been extensively tested in similar studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* Bethesda category III, IV, V or VI following Fine Needle Aspiration; if a patient has a benign tumor following surgery, patient data/ samples will be stored to serve as benign control in potential future projects.
* Age 18 years and older
* Surgical candidate
* Ability to provide informed consent

Exclusion criteria:

* History of thyroid cancer
* Completion surgery candidate
* Pregnant women or other vulnerable patients (e.g. wards of the state, prisoners)

Where it's running

  • Icahn School of Medicine at Mount Sinai
    New York, New York, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.