Optimizing Levothyroxine Dosage for Patients After Thyroid Surgery
Official title: Patient-centered Decision Support Tool for Levothyroxine Dosage
Run by University Hospital of North Norway · NCT06455371 · Data updated 2026-11-12
This study is testing a new tool that helps find the right dose of levothyroxine faster for people who have had their thyroid removed, to see if it improves their health and ability to work compared to regular care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | University Hospital of North Norway Academic / other |
| Locations | 3 sites (Bergen and 2 other locations) |
| Status | Recruiting |
| Started | December 20, 2024 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | September 10, 2025 |
| Trial ID | NCT06455371 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who have had a total thyroidectomy for differentiated thyroid cancer or benign thyroid nodules.
✕Probably not a fit
Patients with anaplastic thyroid cancer, thyroid cancer with distant metastasis, Graves' disease, toxic nodules, or those who are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a decision support tool designed to predict the optimal dosage of levothyroxine for patients who have undergone total thyroidectomy. By analyzing repeated blood samples within the first two weeks of therapy, the tool aims to facilitate quicker dosage adjustments compared to the standard practice of adjusting every two months. The study will compare the outcomes of patients using this tool against those receiving conventional care, focusing on patient-reported outcomes and work ability.
Why it matters
Potential benefit: If successful, this approach could lead to faster and more effective management of levothyroxine therapy, improving patient quality of life.
How similar studies have gone: While the use of decision support tools in medication management is gaining traction, this specific approach for levothyroxine dosage adjustment is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Total or completion thyroidectomy for differentiated thyroid cancer og benign thyroid nodules at Norwegian hospitals Exclusion Criteria: * Anaplastic thyroid cancer, thyroid cancer with distant metastasis, graves disease, toxic nodules, pregnancy
Where it's running
-
Haukeland University Hospital
Bergen, Norway Recruiting -
Oslo University Hospital
Oslo, Norway Recruiting -
University Hospital of North Norway
Tromsø, Norway Recruiting
Study contacts
- Study coordinator: Vegard Brun, PhD
- Email: vegard.heimly.brun@unn.no
- Phone: 0047 77669260
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.