Clinical trial Recruiting at 3 sites Interventional Ages 18 and up

Optimizing Levothyroxine Dosage for Patients After Thyroid Surgery

Official title: Patient-centered Decision Support Tool for Levothyroxine Dosage

Run by University Hospital of North Norway · NCT06455371 · Data updated 2026-11-12

This study is testing a new tool that helps find the right dose of levothyroxine faster for people who have had their thyroid removed, to see if it improves their health and ability to work compared to regular care.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment240 (estimated)
SponsorUniversity Hospital of North Norway
Academic / other
Locations3 sites (Bergen and 2 other locations)
StatusRecruiting
StartedDecember 20, 2024
Main results expectedDecember 2026
Study endsDecember 2027
Registry record updatedSeptember 10, 2025
Trial IDNCT06455371 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients who have had a total thyroidectomy for differentiated thyroid cancer or benign thyroid nodules.

Probably not a fit

Patients with anaplastic thyroid cancer, thyroid cancer with distant metastasis, Graves' disease, toxic nodules, or those who are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a decision support tool designed to predict the optimal dosage of levothyroxine for patients who have undergone total thyroidectomy. By analyzing repeated blood samples within the first two weeks of therapy, the tool aims to facilitate quicker dosage adjustments compared to the standard practice of adjusting every two months. The study will compare the outcomes of patients using this tool against those receiving conventional care, focusing on patient-reported outcomes and work ability.

Why it matters

Potential benefit: If successful, this approach could lead to faster and more effective management of levothyroxine therapy, improving patient quality of life.

How similar studies have gone: While the use of decision support tools in medication management is gaining traction, this specific approach for levothyroxine dosage adjustment is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Total or completion thyroidectomy for differentiated thyroid cancer og benign thyroid nodules at Norwegian hospitals

Exclusion Criteria:

* Anaplastic thyroid cancer, thyroid cancer with distant metastasis, graves disease, toxic nodules, pregnancy

Where it's running

  • Haukeland University Hospital
    Bergen, Norway
    Recruiting
  • Oslo University Hospital
    Oslo, Norway
    Recruiting
  • University Hospital of North Norway
    Tromsø, Norway
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.