Condition

Thrombosis clinical trials and research

• 29Clinical trials
• 126NIH research projects
• 13Countries

Newest Thrombosis clinical trials

All recruiting trials (29)

• Thromboelastometry to Predict Thrombosis and Survival in Glial Tumor Surgery

  Aimed at people with glial tumors undergoing surgery, the study tests whether thromboelastometry and other blood tests can predict blood-clot risk and survival.

  Recruiting Fundacion Clinic per a la Recerca Biomédica · Barcelona · NCT07813377

• Personalized blood-thinner plan for leg artery disease after repair

  A personalized plan using a blood test to tailor antiplatelet therapy is being tested against standard treatment in adults with PAD after a procedure to restore blood flow.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07613840

• Multi-omics search for clotting and bleeding markers in coronary heart disease

  This project will test whether combining proteins, metabolites, genes, sugar tags, and heart images can better predict clotting and major bleeding in people with coronary heart disease on dual antiplatelet therapy.

  Recruiting at 3 sites Chinese Academy of Medical Sciences, Fuwai Hospital · Zhengzhou, Henan and 2 other locations · NCT07523880

• Gruticibart to Prevent Catheter-Related Blood Clots

  This phase II trial tests whether a single dose of gruticibart can prevent blood clots caused by a central venous catheter in adults.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT07498517

• Apixaban vs Warfarin in HeartMate 3 LVAD Patients

  This study tests whether apixaban can replace warfarin to prevent clots and bleeding problems in adults with an implanted HeartMate 3 LVAD for at least 3 months.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07471139

• Safety of perioperative blood thinner management in people with cancer undergoing surgery or procedures

  This study tests how safe current practices are for stopping or continuing blood thinners in adults with cancer who are having surgery or procedures, to see if bleeding or clots are affected.

  Recruiting Ottawa Hospital Research Institute · Ottawa · NCT07372716

• Longitudinal multi-omic platelet volunteer program

  This program will collect regular blood samples and health data from healthy adults to test how platelets, genes, and proteins change over time.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07137429

• Full-dose versus low-dose rivaroxaban for superficial vein clots in the leg

  This pilot will try full-dose rivaroxaban against the usual low dose (followed by placebo) in adults with superficial vein clots in the leg to see if the plan can recruit and run well.

  Recruiting Phase 2/3 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT06965998

• Assessing stroke risk in patients with newly diagnosed atrial fibrillation

  This study is testing how to identify stroke risk in people who have just been diagnosed with atrial fibrillation to see who might need blood-thinning medication to prevent strokes.

  Recruiting University of Southern Denmark · Esbjerg, Region Syddanmark · NCT06949319

• ATHNdataset registry for people with bleeding and clotting disorders

  This registry collects health, treatment, and patient-reported information from people with bleeding and clotting disorders seen at ATHN-affiliated centers to help improve care and outcomes.

  Recruiting American Thrombosis and Hemostasis Network · Hickory, North Carolina · NCT06820515

• Observational study of blood clotting and bleeding disorders in Chinese patients

  This study looks at blood clotting and bleeding problems in Chinese patients to see how common they are and what factors might affect them.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality and 4 other locations · NCT06727669

• Investigating adverse drug events in patients taking blood thinners in the emergency department

  This study looks at how often patients on blood thinners experience problems like bleeding or blood clots when they come to the emergency room.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT06692504

• Testing platelet transfusion thresholds in extremely preterm infants

  This study is testing if giving platelet transfusions at a lower level can help extremely premature babies survive without major bleeding during their first week of life.

  Recruiting at 20 sites NICHD Neonatal Research Network · Birmingham, Alabama and 19 other locations · NCT06676904

• Profiling micro RNA in newborns with congenital heart disease

  This study is trying to understand how certain molecules in the blood of newborns with severe congenital heart disease affect their risk of blood clots during surgery.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06434207

• Thrombin generation testing to predict bleeding in cancer patients on anticoagulants for thrombosis

  This project will test whether a thrombin generation blood test can help predict which cancer patients treated with anticoagulants for a recent deep vein thrombosis or pulmonary embolism are more likely to have bleeding within six months.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Clermont-Ferrand and 3 other locations · NCT06386107

• Preventing blood clots in patients with leg injuries in casts or splints

  This study is testing whether giving tablets or injections to prevent blood clots can help people with leg injuries in casts or splints feel safer compared to standard care.

  Recruiting at 5 sites Phase 3 Queen Mary University of London · Carshalton, Surrey and 4 other locations · NCT06370273

• Examining the link between anti-factor Xa activity and blood clots in critically ill patients

  This study looks at how a specific blood-thinning activity relates to blood clots in critically ill patients in the ICU to see if it affects their health and recovery.

  Recruiting at 3 sites Medical University of Vienna · Graz, Styria and 2 other locations · NCT06357403

• Imaging blood clots in heart arteries to improve heart attack diagnosis

  This study is testing a new imaging method to see if it can help doctors find blood clots in heart arteries to better diagnose heart attacks in patients.

  Recruiting University of Edinburgh · Edinburgh · NCT06113510

• Registry for Endovascular Treatment of Acute Ischemic Stroke

  This study is trying to see how safe and effective a specific treatment for stroke is in helping patients recover after a blocked blood vessel.

  Recruiting Changhai Hospital · Shanghai · NCT05864638

• Imaging and analyzing blood clots in the brain

  This study is testing how brain imaging of blood clots can help doctors understand treatment outcomes for patients with blocked arteries in the brain and neck.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT05663281

• Investigating the role of thrombus in ischaemic stroke

  This study is trying to see how blood clots affect people who have had an ischaemic stroke, using special imaging to better understand their role and improve treatment.

  Recruiting University of Edinburgh · Edinburgh · NCT05636748

• Biorepository for cardiovascular and metabolic disease research

  This study is collecting blood, urine, and stool samples from people with heart and metabolic diseases to help researchers better understand these conditions and improve care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05628948

• Comparing preoperative and postoperative blood clot prevention in pancreatic surgery

  This study is testing whether giving blood clot prevention medication before or after pancreatic surgery works better to keep patients safe from clots.

  Recruiting at 5 sites Phase 4 Helsinki University Central Hospital · Toronto and 4 other locations · NCT05245877

• Using dexamethasone to reduce inflammation after blood clot removal in the leg

  This study is testing if giving dexamethasone directly around the veins after removing a blood clot can help reduce inflammation and improve symptoms for people with deep vein thrombosis.

  Recruiting at 18 sites Phase 2 Mercator MedSystems, Inc. · Scottsdale, Arizona and 21 other locations · NCT04862468

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Long-term observation of non-cancer blood disorders

  This study is tracking people with blood disorders like hemophilia and thrombosis for at least 15 years to see how their conditions change over time and gather useful information for doctors and researchers.

  Recruiting at 74 sites American Thrombosis and Hemostasis Network · Phoenix, Arizona and 75 other locations · NCT04398628

• Registry for patients with Antiphospholipid Syndrome treated with direct oral anticoagulants

  This study is collecting information from adults with Antiphospholipid Syndrome who have been taking blood thinners called direct oral anticoagulants to see how safe and effective they are for these patients.

  Recruiting Central Hospital, Nancy, France · Nancy · NCT04262492

• Imaging thrombosis using a new radiotracer

  This study is testing a new imaging tool to see if it can safely and accurately help detect blood clots in patients with conditions like atrial fibrillation, COVID-19, and cancer.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT03830320

• Evaluating platelet activation in patients with heart support devices

  This study is testing how well platelets work in patients with severe heart failure who are getting or have received a heart support device to see if it can help prevent complications.

  Recruiting Scientific Institute San Raffaele · Milan, MI · NCT03255928

NIH-funded research (newest 40 of 126)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots

  A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.

  NIH research Emory University · Atlanta, United States · NIH-11629726

• Understanding how DVT forms and heals to prevent vein scarring

  This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11522579

• Piezo1’s role in blood clotting across vessels

  Researchers are exploring how a tiny sensor in blood vessels called Piezo1 influences clot formation, with the aim of reducing clotting risks without causing dangerous bleeding.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11451422

• Oscillatory blood flow and vein valve health to prevent clots

  Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.

  NIH research Washington University · Saint Louis, United States · NIH-11448544

• Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT

  Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11446647

• Precision risk tools for blood clots and bleeding in critically ill children

  A pediatric-focused project will use existing data from many hospitals to build and test a risk model that helps doctors decide which very sick kids might benefit from clot-prevention therapies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11445625

• Complement and clotting in JAK2V617F myeloproliferative neoplasms

  A short, patient-friendly study will look at how a specific mutation in blood cells may trigger the body’s complement system to cause clots in people with myeloproliferative neoplasms.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11437026

• Mitochondrial calcium in platelets and stroke risk

  A grant is exploring how mitochondrial calcium channels in platelets affect clotting and stroke outcomes, with the goal of finding new ways to treat ischemic stroke patients.

  NIH research Washington University · Saint Louis, United States · NIH-11434662

• Endothelial TSP1 and anti-thrombotic protection in DVT

  A research team at UW–Madison is studying how a protein on blood vessel linings, TSP1, helps prevent clots in veins and what happens when it’s missing.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11431068

• Understanding how blood and vessel cells drive inflammation, clotting, and atherosclerosis

  A large NIH grant aims to uncover how immune cells and blood vessels interact at the molecular level to influence inflammation, clotting, and heart disease, with findings that could lead to new treatments.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11423184

• Thrombosis risk in teens and young adults starting estrogen

  This project follows young people prescribed estrogen to understand how it changes blood-clotting factors and how doctors decide on preventive care.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11418883

• Role of blood flow properties and transfusion on tiny vessel clots in sepsis

  This grant looks at how the behavior of blood in small vessels and the effect of transfusions might influence clotting and organ failure in people with sepsis.

  NIH research Emory University · Atlanta, United States · NIH-11415830

• Targeting NINJ1 to Prevent Blood Clots Linked to Inflammation

  A study exploring how a specific cell-death process in immune cells worsens clotting during infections and how blocking it could reduce dangerous blood clots.

  NIH research University of Kentucky · Lexington, United States · NIH-11413657

• Dynamic risk tools to prevent blood clots and bleeding in cancer patients

  A new AI-based approach will predict who among people with cancer starting treatment is at higher risk for blood clots or dangerous bleeding, helping doctors tailor preventive care.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11402709

• Targeting cellular metabolism to reduce blood clots without raising bleeding risk

  Researchers are testing a new approach that adjusts how certain blood cells use energy to prevent dangerous clots in arteries, while aiming to keep bleeding risk low.

  NIH research University of Iowa · Iowa City, United States · NIH-11399989

• CD39-bearing tiny vesicles may guard lungs in SCD patients

  A study in people with sickle cell disease explores whether extracellular vesicles carrying CD39 protect the lungs from blood clots during acute illness.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11397728

• Neutrophil integrin α9 and blood clots after stroke in aging

  This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11396538

• Regulation of blood clotting by C1 inhibitor

  Researchers are studying how C1 inhibitor controls a specific blood-clotting pathway and how this affects risk of blood clots in people who have a deficiency or related conditions.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11396243

• Ultra-thin, strong drug-eluting sutures to prevent clotting after microsurgery

  A Johns Hopkins team is testing ultra-thin, strong sutures that release medicine locally to keep tiny blood vessels open after microsurgery.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11396231

• Endothelial contribution to blood-clotting in myeloproliferative neoplasms

  This project explores how the lining of blood vessels may drive dangerous clots in people with myeloproliferative neoplasms (MPNs).

  NIH research University of Minnesota · Minneapolis, United States · NIH-11392884

• Computational modeling of platelets and blood flow to predict cerebral aneurysm treatment outcomes

  A researchers at UW are using computer models of blood flow and platelets to better predict whether an aneurysm treatment will work.

  NIH research University of Washington · Seattle, United States · NIH-11385494

• Hemostasis and Thrombosis: How Blood Clotting Enzymes Work

  A multi-project NIH grant at Children’s Hospital of Philadelphia explores how blood-clotting enzymes function and are regulated at the molecular level, with potential implications for better treatments of clotting disorders.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11383542

• Hypoxia-inducible factors and neutrophil diversity in blood clotting in myeloproliferative neoplasms

  A physician-scientist is training over five years to uncover how low-oxygen signals and diverse neutrophils drive dangerous clots in people with myeloproliferative neoplasms, with the goal of finding new treatment targets.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11380793

• Sodium Pump, Sex Hormones, and Blood Clots

  A study to understand how a common “sodium pump” protein and sex hormones affect the risk of blood clots in people.

  NIH research Marshall University · Huntington, UNITED STATES · NIH-11378808

• Treating long-standing leg clots with ultrasound-powered therapy and clot-busting drugs

  A doctor-scientist team is testing a combo of ultrasound-based tissue disruption and clot-busting medicine to improve treatment for people with chronic DVT.

  NIH research University of Chicago · Chicago, United States · NIH-11378531

• Understanding why some CKD patients have more blood clots after vascular procedures

  This NIH grant explores why people with chronic kidney disease are more prone to blood clots after vascular interventions and how to prevent them.

  NIH research Boston Medical Center · Boston, United States · NIH-11378494

• Venous clots after trauma: finding who’s at risk and how to prevent them

  This grant aims to understand why people who have experienced serious injuries develop dangerous blood clots after leaving the hospital, and how to predict and prevent those events.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11378463

• Contact Pathway Inhibitor to Prevent Catheter-Related Thrombosis

  A new treatment approach uses AB023 (gruticibart) aimed at preventing blood clots and inflammation around central venous catheters to keep them working safely in cancer patients.

  NIH research Aronora, INC. · Portland, UNITED STATES · NIH-11375995

• Metabolic tricks to prevent and heal dangerous blood clots in the leg

  A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.

  NIH research University of Iowa · Iowa City, United States · NIH-11375490

• Thrombosis and Bleeding Risk in Medical Inpatients

  A patient-facing program to better predict who is at risk for blood clots or bleeding during and after hospital stays, and to tailor prevention accordingly.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11366383

• Slippery coating to keep vascular grafts clear and clean

  A new, super-slick coating is being tested to prevent clotting and infection on artificial blood vessels used in leg procedures.

  NIH research Cerulean Scientific INC. · Lancaster, United States · NIH-11364195

• Gut bacteria and heart disease: promising new pathways to reduce atherosclerosis and clots

  A researchers team is studying how certain gut bacteria make chemicals that may influence heart disease and clotting, with findings that could lead to new ways to prevent or treat these conditions.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11335426

• A new slippery coating for vascular grafts to prevent blockages and infections

  This project is developing a special coating for blood vessel grafts to help them stay open and free from infection in patients with severe circulation problems.

  NIH research Cerulean Scientific INC. · Lancaster, United States · NIH-11326089

• Role of blood group antigens in how platelets help or hinder bleeding and clots

  A study at Brigham and Women’s Hospital will look at how ABO blood group sugars on platelets affect bleeding risk and clotting risk in people.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11325438

• Preventing blood clots by lowering fibrinogen or blocking fibrin clot formation

  Researchers are trying to reduce dangerous arterial and venous blood clots in people at risk by lowering the blood protein fibrinogen or preventing dense fibrin networks that make clots hard to break down.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11321525

• Engineered nitric oxide releasing IV catheters with solid slippery surfaces to prevent infection and clotting

  A patient-facing overview of a new coating for short-term vascular access catheters that aims to lower risk of infection and blood clots.

  NIH research Nytricx INC. · Athens, United States · NIH-11313954

• How platelets release and take in materials to control clots and fight infections

  Looking at how platelets release and absorb materials to help control blood clots and immune responses for people with clotting or immune-related conditions.

  NIH research University of Kentucky · Lexington, United States · NIH-11309170

• Cancer immunotherapy–related blood clots: what we’re learning in mice and people

  Researchers are studying why some cancer patients receiving immune checkpoint inhibitors develop dangerous blood clots and how this could be prevented or treated.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11309103

• Immune cell 'nets' and inflammation in heart and lung scarring

  This project looks at how neutrophil 'nets' and inflammation help form blood clots and cause scarring in the heart and lungs.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11300191

• Blocking the FXIII-fibrinogen kiss to prevent dangerous clots

  A patient-facing research opportunity to explore how stopping a specific clot-strengthening interaction could reduce dangerous blood clots without stopping normal clotting.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11297264

Related topics

Quick answers

How many Thrombosis clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (11 trials), United Kingdom (4 trials), China (4 trials), France (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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