Hemostasis and Thrombosis: How Blood Clotting Enzymes Work
Official title: Hemostasis and Thrombosis: Chemistry, Biology and Physiology
Funded at Children's Hosp of Philadelphia · NIH-11383542 · Data updated 2026-11-12
A multi-project NIH grant at Children’s Hospital of Philadelphia explores how blood-clotting enzymes function and are regulated at the molecular level, with potential implications for better treatments of clotting disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2018 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,950,099 |
| NIH project number | 5P01HL139420-08 |
| Project ID | NIH-11383542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing trial; however, findings may eventually translate to improved treatments for people with coagulation disorders.
✕Less likely to help
No direct patient participation in this basic science program.
What this research studies
This program brings together several projects to understand how blood coagulation enzymes work on cell membranes and how their activity can be controlled. Researchers will study the prothrombinase complex, factor V conversion to factor Va, and innovative RNA aptamer inhibitors to block active sites while keeping the system reversible. The work uses advanced techniques to look at enzyme structure, interactions with cofactors, and how membranes influence function. The goal is to uncover fundamental mechanisms that could lead to more precise therapies for abnormal clotting.
Why it matters
Potential benefit: If successful, this work could inform the design of safer and more targeted therapies for blood-clotting disorders.
How similar studies have gone: Previous research has shown that understanding enzyme complexes can reveal new regulatory mechanisms in coagulation.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Krishnaswamy, Sriram — Children's Hosp of Philadelphia
- Study coordinator: Krishnaswamy, Sriram
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.