Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
Official title: The Role of Rheology and Transfusion on Microvascular Thrombosis in Sepsis
Funded at Emory University · NIH-11629726 · Data updated 2026-11-12
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 12, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $69,999 |
| NIH project number | 3K38HL181374-02S1 |
| Project ID | NIH-11629726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with sepsis or ICU admission where microvascular issues and clotting are concerns; future trials would focus on those with suspected endothelial injury and coagulopathy.
✕Less likely to help
Patients without sepsis or microvascular complications may not benefit from this line of investigation.
What this research studies
This grant explores how the physical properties of blood in the smallest vessels affect organ function during sepsis. Researchers will use microfluidic tests to study how red blood cell clumping and cell membrane flexibility influence the endothelial cells that line blood vessels, and how this relates to clotting and tissue injury. The project also considers whether adjusting blood properties through transfusion could improve perfusion and reduce clot formation in septic patients. The aim is to identify markers and interventions that could guide future therapies for those in the ICU with sepsis.
Why it matters
Potential benefit: If successful, it could lead to new ways to prevent organ failure in septic patients by guiding transfusion practices and therapies that improve microvascular flow.
How similar studies have gone: Earlier work suggests microvascular flow and cell interactions influence outcomes in sepsis, with some promising links between rheology and endothelial function.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Iffrig, Elizabeth M — Emory University
- Study coordinator: Iffrig, Elizabeth M
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.