Regulation of blood clotting by C1 inhibitor
Official title: Regulation of coagulation and thrombosis by C1 inhibitor
Funded at Beth Israel Deaconess Medical Center · NIH-11396243 · Data updated 2026-11-12
Researchers are studying how C1 inhibitor controls a specific blood-clotting pathway and how this affects risk of blood clots in people who have a deficiency or related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $690,184 |
| NIH project number | 5R01HL171042-03 |
| Project ID | NIH-11396243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with C1 inhibitor deficiency or related coagulation abnormalities, particularly those at risk for venous thromboembolism.
✕Less likely to help
General population without C1 inhibitor–related coagulation issues may not directly benefit.
What this research studies
This project looks at how the body's natural anticoagulant C1 inhibitor helps regulate the contact pathway of coagulation, which can contribute to venous clots. Using mouse models and patient-derived plasma, the team will examine how deficiencies or alterations in C1 inhibitor influence clot formation and whether certain anticoagulants can correct these effects. The work aims to identify mechanisms and potential interventions that could reduce clot risk in affected patients. The study is rooted in observations from hereditary angioedema patients who show increased coagulation activity and thrombotic risk.
Why it matters
Potential benefit: If successful, findings could lead to better strategies to prevent or treat blood clots in people with C1 inhibitor-related conditions.
How similar studies have gone: Prior work in animals and human plasma suggests that modifying the contact pathway can alter thrombosis risk, supporting potential translation to patients.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Grover, Steven P. — Beth Israel Deaconess Medical Center
- Study coordinator: Grover, Steven P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.