Condition

Pulmonary Embolism clinical trials and research

• 50Clinical trials
• 24NIH research projects
• 24Countries

Newest Pulmonary Embolism clinical trials

All recruiting trials (50)

• TRiP-cast score test in adults with acute lower-limb injuries requiring immobilization

  This study tests whether the TRiP(cast) score can predict risk of blood clots in adults with acute lower-limb injuries treated as outpatients.

  Recruiting University of Monastir · Monastir · NCT07863115

• Prognostic value of the 2026 AHA/ACC PE classification in ED patients with acute PE

  This study tests whether the 2026 AHA/ACC five-category PE classification helps predict 30-day major adverse pulmonary embolism events in adults with acute PE presenting to the ED.

  Recruiting Marmara University Pendik Training and Research Hospital · Istanbul · NCT07805616

• Right heart dysfunction in acute pulmonary embolism: can echocardiography help predict risk

  This study tests whether transthoracic echocardiography can identify right ventricular dysfunction in adults with acute pulmonary embolism to help gauge risk.

  Recruiting Sohag University · Sohag and 1 other locations · NCT07647497

• Aspiration thrombectomy with the Symphony or Prodigy devices

  This project will try the Symphony and Prodigy aspiration thrombectomy devices to remove arterial, venous, or pulmonary blood clots in adults.

  Recruiting at 13 sites Imperative Care, Inc. · Huntsville, Alabama and 12 other locations · NCT07350499

• PERC and YEARS approaches for diagnosing pulmonary embolism in the emergency department.

  This project will test whether using the PERC score and the YEARS algorithm helps emergency doctors decide which adults need D-dimer blood tests or chest CT scans to diagnose pulmonary embolism.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07313501

• Reperfusion options for acute pulmonary embolism

  This project will try catheter-directed interventions or systemic thrombolysis in adults with acute pulmonary embolism to see which approach leads to better outcomes.

  Recruiting at 12 sites Sahlgrenska University Hospital · Aarhus and 12 other locations · NCT07003646

• Evaluating anticoagulation duration for pulmonary embolism in ICU patients

  This study is testing how long ICU patients with serious pulmonary embolism should be treated with blood thinners to see how well it helps them recover.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06912009

• Timing of anticoagulation for preventing blood clots in patients with brain hemorrhage

  This study is testing whether starting blood-thinning treatment early or later can help prevent blood clots in patients with bleeding in the brain while keeping them safe from more bleeding.

  Recruiting Pirogov Russian National Research Medical University · Moscow · NCT06753786

• Observational study of blood clotting and bleeding disorders in Chinese patients

  This study looks at blood clotting and bleeding problems in Chinese patients to see how common they are and what factors might affect them.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality and 4 other locations · NCT06727669

• Removing lung blood clots with the AlphaVac mechanical aspiration device

  This trial tests whether using the AlphaVac mechanical aspiration device to remove clots helps adults with recent acute pulmonary embolism and signs of right-heart strain or clinical compromise.

  Recruiting Angiodynamics, Inc. · Poznan · NCT06697314

• Home-based exercise program for patients with pulmonary embolism

  This study is testing a home-based exercise program to help people recovering from pulmonary embolism improve their mobility and overall health.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06695247

• Impact of discovering pulmonary emboli during CT scans on patient care

  This study looks at how often doctors find unexpected blood clots in the lungs during chest scans of ICU patients and what that means for their treatment.

  Recruiting Meir Medical Center · Kfar Saba · NCT06622876

• Registry for patients treated with Inari Medical devices for pulmonary embolism

  This study collects information from patients treated for pulmonary embolism using Inari Medical devices to see how well they work and how safe they are in real life.

  Recruiting at 14 sites Inari Medical · Paris and 13 other locations · NCT06600542

• Comparing FlowTriever System to Standard Care for High-Risk Pulmonary Embolism

  This study tests if the FlowTriever System can help people with high-risk pulmonary embolism feel better compared to standard treatment.

  Recruiting at 34 sites Inari Medical · New Haven, Connecticut and 33 other locations · NCT06588634

• Personalized blood thinner treatment for hip and knee replacement patients

  This study is testing if personalized blood thinner treatments can better prevent blood clots and bleeding in patients getting hip or knee replacements compared to standard treatments.

  Recruiting at 12 sites Phase 4 Leiden University Medical Center · Apeldoorn, Gelderland and 12 other locations · NCT06581965

• Using portable dynamic chest X-ray in the ICU

  This study is testing a new portable chest X-ray system in the ICU to see if it can give better pictures of lung movement and function compared to regular X-rays and CT scans for critically ill patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06538376

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Using AI to improve imaging for pulmonary embolism diagnosis

  This study is testing if using advanced imaging and artificial intelligence can help doctors diagnose and manage pulmonary embolism better for patients who might have it.

  Recruiting China-Japan Friendship Hospital · Beijing · NCT06526468

• Evaluating a new decision support tool for diagnosing blood clots

  This study is testing a new tool to help doctors diagnose blood clots in patients who might have conditions like pulmonary embolism or deep vein thrombosis, using fresh blood samples.

  Recruiting at 4 sites Diagnostica Stago R&D · Niort, Sartres and 3 other locations · NCT06480994

• Three-arm treatment test for intermediate-high risk pulmonary embolism in adults

  This trial tests whether catheter-based embolectomy or low-dose thrombolysis or standard heparin alone can reduce clot burden in adults with acute intermediate-high risk pulmonary embolism.

  Recruiting Phase 3 Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT06453876

• BASHIR Endovascular Catheter Therapy for Intermediate-Risk Pulmonary Embolism

  This study tests whether the Bashir endovascular catheter with low-dose rt-PA can safely treat intermediate-risk pulmonary embolism by delivering medication directly into the pulmonary arteries.

  Recruiting at 23 sites Thrombolex, Inc. · Scottsdale, Arizona and 22 other locations · NCT06433011

• Thrombin generation testing to predict bleeding in cancer patients on anticoagulants for thrombosis

  This project will test whether a thrombin generation blood test can help predict which cancer patients treated with anticoagulants for a recent deep vein thrombosis or pulmonary embolism are more likely to have bleeding within six months.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Clermont-Ferrand and 3 other locations · NCT06386107

• Pharmacy-led intervention to improve medication adherence after hospital discharge

  This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital.

  Recruiting University of Tennessee · Knoxville, Tennessee and 1 other locations · NCT06374277

• Using advanced imaging to predict the risk of blood clot recurrence in pulmonary embolism patients

  This study is testing if advanced imaging can help find out which patients with a history of pulmonary embolism are at risk for blood clots coming back, so they can get the right treatment.

  Recruiting at 11 sites University Hospital, Brest · Amiens, France and 12 other locations · NCT06372730

• Comparing a new treatment for pulmonary embolism to a placebo

  This study is testing a new treatment for pulmonary embolism to see if it helps patients feel better without causing serious bleeding, compared to a placebo.

  Recruiting at 21 sites Phase 3 Supergene, LLC · Barnaul, Altayskiy Kray and 23 other locations · NCT06362746

• Monitoring and dosing guidance for anticoagulants in pulmonary embolism patients

  This study is testing a new way to monitor and adjust blood-thinning medication for people with pulmonary embolism to see if it can improve their treatment outcomes.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06362343

• Examining the link between anti-factor Xa activity and blood clots in critically ill patients

  This study looks at how a specific blood-thinning activity relates to blood clots in critically ill patients in the ICU to see if it affects their health and recovery.

  Recruiting at 3 sites Medical University of Vienna · Graz, Styria and 2 other locations · NCT06357403

• Registry of catheter interventions for pulmonary embolism

  This study looks at how safe and effective different catheter treatments are for people with moderate to high-risk pulmonary embolism.

  Recruiting Hospital San Carlos, Madrid · Madrid, Madrid · NCT06348459

• New tool for diagnosing pulmonary embolism in emergency departments

  This study is testing a new tool to help emergency doctors decide when imaging for pulmonary embolism is really needed, aiming to reduce unnecessary scans and radiation exposure for patients.

  Recruiting at 2 sites Queen's University · Hamilton, Ontario and 3 other locations · NCT06320236

• Comparing rivaroxaban and low-molecular weight heparin for preventing blood clots in patients with lower limb trauma

  This study is testing if a new blood thinner called rivaroxaban can prevent blood clots better than a standard treatment in patients with leg injuries who are at high risk for clots.

  Recruiting at 26 sites Phase 3 University Hospital, Angers · Agen and 36 other locations · NCT06195540

• Chair lift test to predict outcomes after non-severe pulmonary embolism

  We will test whether a chair lift test can help predict short-term outcomes for hospitalized adults with non-severe pulmonary embolism.

  Recruiting University Hospital, Rouen · Rouen · NCT06166329

• Ultrasound-assisted treatment for acute pulmonary embolism

  This study is testing if using ultrasound to help break up blood clots in patients with serious pulmonary embolism can reduce the chances of developing high blood pressure in the lungs within six months.

  Recruiting Niguarda Hospital · Milan, Italia · NCT06143969

• Treatment of pulmonary embolism using the Laguna Thrombectomy System

  This study is testing a new device to see if it can safely and effectively treat pulmonary embolism in patients who have had symptoms for 14 days or less.

  Recruiting at 13 sites Innova Vascular, Inc. · Birmingham, Alabama and 20 other locations · NCT06041594

• Structured follow-up model for patients after pulmonary embolism

  This study is testing a new follow-up care plan for people who have had a pulmonary embolism to see if it helps them feel better and use healthcare services more effectively.

  Recruiting Aalborg University Hospital · Aalborg · NCT06037096

• Using supplemental oxygen to treat pulmonary embolism

  This study is testing if giving extra oxygen to people with acute pulmonary embolism can help their heart function better and improve their overall health.

  Recruiting Early Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT05891886

• Study on the safety and performance of Celect Platinum Vena Cava Filters

  This study is testing how safe and effective the Celect Platinum Vena Cava Filters are for patients over time after they've had them placed in their bodies.

  Recruiting at 7 sites Cook Group Incorporated · Los Angeles, California and 6 other locations · NCT05881798

• Using geko device to prevent blood clots in stroke patients

  This study is testing if the geko™ device can help prevent blood clots in stroke patients who can’t move around, compared to the standard treatment they usually get.

  Recruiting at 17 sites Firstkind Ltd · Bury St Edmunds, Suffolk and 17 other locations · NCT05476913

• Treatment of low-risk submassive pulmonary embolism using FlowTriever

  This study is testing if the FlowTriever device can safely treat people with low-risk submassive pulmonary embolism who are stable and have certain health markers.

  Recruiting Northwell Health · Mount Kisco, New York and 1 other locations · NCT05273762

• Early detection of deep vein thrombosis in critically ill patients

  This study tests if regular ultrasound checks can help find blood clots in critically ill patients to see if it can lower the risk of serious complications and improve survival rates.

  Recruiting King Abdullah International Medical Research Center · Riyadh, Riyadh Region · NCT05112705

• Assessing lung function after pulmonary embolism using advanced imaging techniques

  This study is testing advanced imaging techniques to see how well the lungs are working in people who have had a pulmonary embolism and still have trouble breathing, to help improve their rehabilitation.

  Recruiting University Hospital, Brest · Brest · NCT05103670

• Using ultrasound to predict outcomes in emergency patients with pulmonary embolism

  This study is testing whether using ultrasound in the emergency room can help doctors predict how well patients with pulmonary embolism will do in the short term.

  Recruiting WellSpan Health · York, Pennsylvania · NCT05050617

• Improving quality of life with pulmonary rehabilitation after pulmonary embolism

  This study is testing whether a structured pulmonary rehabilitation program can help adults who have had a pulmonary embolism feel better and improve their quality of life, even after taking blood thinners.

  Recruiting at 6 sites University Hospital, Brest · Brest, France and 5 other locations · NCT05015153

• Evaluating the long-term safety and outcomes of the Indigo Aspiration System for pulmonary embolism treatment

  This study is testing how safe and effective the Indigo Aspiration System is for treating pulmonary embolism in patients over the long term.

  Recruiting at 74 sites Penumbra Inc. · Long Beach, California and 78 other locations · NCT04798261

• Investigating the link between clonal hematopoiesis and unprovoked pulmonary embolism

  This study is trying to see if a blood condition called clonal hematopoiesis is common in people who have had a sudden pulmonary embolism without any clear cause.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04711746

• Outpatient pulmonary rehabilitation for patients after pulmonary embolism

  This study is testing whether a 6-week outpatient rehabilitation program can help people recover better and feel healthier after experiencing a pulmonary embolism.

  Recruiting Medical University of Vienna · Vienna · NCT04615130

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Investigating outcomes after treatment for pulmonary embolism

  This study looks at how well different treatments for pulmonary embolism work and how safe they are for patients, using data from a team of experts.

  Recruiting at 2 sites Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern and 1 other locations · NCT04355975

• Comparing clinical surveillance to anticoagulation for low-risk patients with isolated pulmonary embolism

  This study is testing whether low-risk patients with isolated pulmonary embolism can safely be monitored without blood thinners instead of taking them.

  Recruiting at 29 sites Phase 4 Insel Gruppe AG, University Hospital Bern · Woluwe-Saint-Lambert, Brussels Capital and 39 other locations · NCT04263038

• CHIPs-VTE program to prevent hospital-acquired blood clots in hospitalized patients

  This project tests whether a hospital-wide package of risk checks, computer alerts, staff education, and audits can increase appropriate clot-prevention for hospitalized patients in China.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT04211181

• Registry of patients treated for venous thromboembolism

  This study is tracking patients with blood clots to see how different treatments work and to help with future research.

  Recruiting Medalp Private Surgery Clinic · Moscow, Moscow · NCT03881345

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-powered tool to better predict and manage acute pulmonary embolism

  A new AI system uses imaging and patient data to improve how doctors predict short-term risk and tailor treatment for people with acute pulmonary embolism.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11452851

• Endovascular vortex ultrasound to treat blood clots in the lungs

  A new therapy uses a tiny ultrasound device inside the blood vessels to rapidly dissolve clots in the lungs of people with pulmonary embolism, aiming to reduce the need for high doses of clot-busting drugs.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11448155

• Supplemental Oxygen for Pulmonary Embolism: A Mechanistic Look at How Oxygen Helps the Heart and Lungs

  This NIH grant tests how giving extra oxygen affects lung pressure and heart strain in people with acute pulmonary embolism, with supportive animal studies to understand the biology.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11401200

• Pulmonary embolism: catheter-directed clot removal for better outcomes

  This trial tests whether delivering clot-dissolving medication directly to the lungs via a catheter helps people with submassive pulmonary embolism feel better and function better, with fewer bleeding risks.

  NIH research New York University School of Medicine · New York, United States · NIH-11384861

• Pulmonary embolism treatment with catheter-directed thrombus removal versus no catheter therapy

  This study tests whether removing clot with a targeted catheter approach helps people with submassive pulmonary embolism feel better and move more easily, compared with not using catheter therapy.

  NIH research New York University School of Medicine · New York, United States · NIH-11381072

• Molecular and imaging study of blood clots and inflammation in pulmonary embolism

  A research project uses a mouse model to understand how blood clots and inflammatory cells affect pulmonary embolism and its outcomes, with the goal of better diagnosis and treatment for people with PE.

  NIH research Masonic Medical Research Laboratory, INC · Utica, United States · NIH-11333828

• Helping ER doctors use a pulmonary embolism risk tool

  This project adds simple behavioral "nudges" to an electronic pulmonary embolism risk tool to help ER doctors pick the right patients for CT scans, aiming to cut down on unnecessary scans for people with suspected PE.

  NIH research New York University School of Medicine · New York, United States · NIH-11333795

• Safer outpatient care options for low-risk pulmonary embolism after an ER visit

  A program that helps emergency doctors safely treat people with low-risk pulmonary embolism at home with anticoagulant medicines and arranged follow-up.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11257997

• Understanding Blood Clots and Inflammation in Pulmonary Embolism

  This research looks for better ways to understand and treat pulmonary embolism, a serious condition caused by blood clots in the lungs.

  NIH research Masonic Medical Research Laboratory, INC · Utica, United States · NIH-11192923

• Catheter clot removal for submassive pulmonary embolism

  This trial compares catheter-directed clot removal to usual care for adults with submassive pulmonary embolism to help improve breathing and heart function.

  NIH research New York University School of Medicine · New York, United States · NIH-11167711

• Catheter removal of lung blood clots for submassive pulmonary embolism

  This compares catheter-directed clot removal with lower-dose clot-busting medicine to usual care for people who have submassive pulmonary embolism with right-heart strain but normal blood pressure.

  NIH research New York University School of Medicine · New York, United States · NIH-11167691

• Extra oxygen to help people with pulmonary embolism

  Seeing if giving extra oxygen lowers pressure in the lungs and eases right‑heart strain for people with acute pulmonary embolism.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11159758

• Improving how doctors use a tool to predict the risk of pulmonary embolism.

  This study is looking at ways to help doctors in emergency rooms use a special tool that predicts the risk of blood clots in the lungs, so they can make better decisions about whether to do CT scans, which can sometimes be unnecessary and expose patients to extra radiation.

  NIH research New York University School of Medicine · New York, United States · NIH-11051198

• Improving outpatient management for low-risk pulmonary embolism patients

  This study is looking at ways to help doctors in emergency rooms safely send home patients with low-risk pulmonary embolism instead of keeping them in the hospital, making sure they have the right medications and follow-up care they need.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11017732

• Investigating blood clot formation and inflammation in pulmonary embolism

  This study is looking at how blood clots form and cause lung inflammation in people with pulmonary embolism, using a special mouse model to help find better ways to diagnose and treat patients who might be at risk for complications.

  NIH research Masonic Medical Research Laboratory, INC · Utica, United States · NIH-10980911

• Removing blood clots in patients with pulmonary embolism using catheters

  This study is looking at whether a special treatment called catheter-directed therapy can help people with submassive pulmonary embolism breathe better and feel healthier over time, compared to those who don’t receive this treatment.

  NIH research New York University School of Medicine · New York, United States · NIH-10929511

• Removing blood clots in patients with pulmonary embolism using catheter therapy

  This study is looking at how well a special treatment called catheter-directed therapy (CDT) works for people with submassive pulmonary embolism (PE), which is when blood clots block blood flow to the lungs, and it will compare the results of those who get this treatment to those who don’t, all while aiming to help imp

  NIH research New York University School of Medicine · New York, United States · NIH-10928723

• Using supplemental oxygen to treat pulmonary embolism

  This study is looking at how extra oxygen might help people with acute pulmonary embolism by easing pressure in the lungs and helping the heart work better, and it will involve patients in the emergency department at Massachusetts General Hospital as well as some research with pigs to see if the same benefits can apply

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10918051

• Predicting outcomes for patients with pulmonary embolism using imaging and clinical data

  This study is looking at ways to better treat pulmonary embolism (PE) by using computer technology to combine medical records and CT scan images, helping doctors identify patients who might be at higher risk and tailor their treatment for better outcomes.

  NIH research Stanford University · Stanford, United States · NIH-10914037

• Reducing unnecessary imaging for pulmonary embolism in emergency departments

  This study is looking to reduce the number of unnecessary CT scans for blood clots in the lungs by helping doctors understand when these tests are really needed, so patients can stay safer and avoid extra costs and risks.

  NIH research Baystate Medical Center, INC. · Springfield, United States · NIH-10907744

• Using AI to quickly detect pulmonary embolism

  This study is working on a smart computer program that helps doctors quickly and accurately find pulmonary embolism (PE) using a simple heart ultrasound, so even those who aren't specialists can help catch this serious condition early and get patients the treatment they need faster.

  NIH research University of Arizona · Tucson, United States · NIH-10852966

• Evaluating a new method to safely rule out pulmonary embolism in children without using radiation

  This study is testing a new way to help doctors figure out if kids aged 5-17 might have a blood clot in their lungs, called pulmonary embolism, so they can avoid unnecessary scans and still make sure those who need treatment get it quickly.

  NIH research Wayne State University · Detroit, United States · NIH-10841548

• Using technology to help patients recover at home after a pulmonary embolism

  This study is looking at how a special online rehab program can help people recover at home after being in the hospital for a blood clot in the lungs, using wearable devices to track their heart rate and activity so they can get personalized exercise plans to feel better.

  NIH research University of Rochester · Rochester, United States · NIH-10784489

• Using machine learning to improve detection of pulmonary embolism

  This study is working on a new software that helps doctors quickly and accurately find blood clots in the lungs using routine CT scans, making it easier for patients to get the right treatment faster.

  NIH research Minnesota Healthsolutions Corporation · Saint Paul, United States · NIH-10576273

Related topics

Quick answers

How many Pulmonary Embolism clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in France (13 trials), United States (12 trials), United Kingdom (5 trials), China (5 trials), Netherlands (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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