Contact Pathway Inhibitor to Prevent Catheter-Related Thrombosis
Funded at Aronora, INC. · NIH-11375995 · Data updated 2026-11-12
A new treatment approach uses AB023 (gruticibart) aimed at preventing blood clots and inflammation around central venous catheters to keep them working safely in cancer patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Aronora, INC. NIH-funded |
| Lab location | 1 site (Portland, UNITED STATES) |
| Project start | June 15, 2024 |
| Project end | June 14, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,069,527 |
| NIH project number | 5R44HL170881-03 |
| Project ID | NIH-11375995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cancer who require a central venous catheter (including PICCs or implanted ports) and are at risk for CRT.
✕Less likely to help
Patients not receiving central venous catheter therapy or those without cancer-related CRT risk may not benefit.
What this research studies
This project focuses on people who need long-term central venous catheters for cancer treatment or supportive care. It tests a novel agent that targets the contact activation pathway to reduce catheter-related thrombosis and inflammation, potentially lowering device-related complications. The work builds on a small prior study in cancer patients with catheters and advances toward a larger, practical prevention strategy. If successful, it could lead to safer catheter use and fewer procedure-related problems.
Why it matters
Potential benefit: If successful, patients could experience fewer catheter-related clots and infections, leading to safer and more reliable catheter access for treatment.
How similar studies have gone: Preliminary phase 2 data in cancer patients with catheters suggests potential benefit, justifying further development.
Where this research is happening
-
Aronora, INC.
Portland, United States Active
Researchers
- Principal investigator: Lorentz, Christina U — Aronora, INC.
- Study coordinator: Lorentz, Christina U
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.