Understanding how DVT forms and heals to prevent vein scarring
Official title: Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis
Funded at Portland VA Medical Center · NIH-11522579 · Data updated 2026-11-12
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| NIH project number | 5IK2CX001720-07 |
| Project ID | NIH-11522579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with deep vein thrombosis or at risk of DVT and its complications may be relevant for related translational studies or future trials.
✕Less likely to help
This grant is focused on researchers and translational work; individual patients may not directly participate in every component.
What this research studies
A vascular surgeon-scientist at the VA and a university partner will combine basic and translational research to understand inflammation and fibrosis during DVT healing. The project emphasizes how clots form, resolve, and sometimes leave lasting vein damage that leads to post-thrombotic syndrome. By studying vein tissue, immune signals, and remodeling, the team aims to identify targets that could reduce scarring and improve recovery after DVT. The work builds on existing clinical observations and uses laboratory and translational approaches to connect biology with patient care.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to prevent vein-wall damage and post-thrombotic syndrome after DVT.
How similar studies have gone: Previous work has shown inflammation and fibrosis influence vein healing; this proposal aims to extend those findings toward new therapeutic approaches.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Nguyen, Khanh P. — Portland VA Medical Center
- Study coordinator: Nguyen, Khanh P.
Related research
Other NIH-funded projects on the same topics.
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Understanding how blood clots in deep veins can lead to long-term complications
This study is looking into how deep vein thrombosis (DVT) affects healing and can lead to long-term problems like post-thrombotic syndrome (PTS), with the goal of finding better treatments for people dealing with these issues.
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Oscillatory blood flow and vein valve health to prevent clots
Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.
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Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
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Neutrophil integrin α9 and blood clots after stroke in aging
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
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Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
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Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.