Investigating the role of thrombus in ischaemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the origin and role of thromboembolism in patients with ischaemic stroke, including those with cryptogenic and lacunar strokes. Utilizing a novel thrombus-specific radiotracer, 18F-GP1, the study will assess its effectiveness in identifying thrombus formation and its clinical implications. The research will involve various imaging techniques, including PET/CT and MRI, to provide insights into the mechanisms behind stroke and improve diagnostic accuracy. By understanding the thrombus's role, the study seeks to enhance patient management and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males and females ≥18 years old
* Diagnoses of acute ischaemic stroke (within 21 days of symptom onset) as per American Heart and Stroke Association guidelines

Exclusion Criteria:

* Inability or unwillingness to provide informed written consent (ie lack capacity)
* Inability to undergo the scanning protocol including ability to transfer onto the scanner
* Women of child- bearing potential in whom pregnancy cannot be excluded
* Contraindication to PET-CT scanning including estimated glomerular filtration rate \<30 mL/min/1.73 m2
* Participation in the study would result in a delay to carotid endarterectomy surgery
* Known allergy to iodinated contrast or radiotracer
* Severe or significant comorbidity precluding ability to complete study procedures.
* Haemorrhagic stroke
* Contra-indication to Magnetic Resonance imaging for those patients requiring a MRI Head

Where it's running

• Clinical Research Facility
  Edinburgh, United Kingdom Recruiting

Study contacts

• Study coordinator: Beth Whittington, MD
• Email: bwhittin@ed.ac.uk
• Phone: 01312426200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.