Understanding how blood and vessel cells drive inflammation, clotting, and atherosclerosis
Official title: Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis
Funded at University of California, San Diego · NIH-11423184 · Data updated 2026-11-12
A large NIH grant aims to uncover how immune cells and blood vessels interact at the molecular level to influence inflammation, clotting, and heart disease, with findings that could lead to new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,363,208 |
| NIH project number | 2P01HL151433-06A1 |
| Project ID | NIH-11423184 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with atherosclerotic cardiovascular disease or vascular inflammation may benefit from future biomarker-guided therapies or preventive strategies.
✕Less likely to help
Individuals without ASCVD or vascular inflammatory conditions may not directly benefit from these findings.
What this research studies
This program will study how adhesion signals and immune pathways shape vascular inflammation and thrombosis. Four projects will test ideas about IL-2 signaling, a low-affinity form of a clotting receptor, chromatin changes in endothelial cells, and neutrophil adhesion. A core unit will help map where and how genes and proteins are active in blood and vascular cells inside tissues. The work combines advanced molecular imaging and multi-omic analyses to understand disease processes that contribute to ASCVD.
Why it matters
Potential benefit: If successful, the research could identify new biomarkers and targets to prevent or treat inflammatory vascular diseases and thrombosis.
How similar studies have gone: This approach builds on prior work in leukocyte signaling and endothelial biology, with a strong likelihood of yielding new mechanistic insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Ginsberg, Mark Howard — University of California, San Diego
- Study coordinator: Ginsberg, Mark Howard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.