Thrombosis risk in teens and young adults starting estrogen
Official title: Thrombosis Risk in Adolescents and Young Adults Starting Estrogen
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11418883 · Data updated 2026-11-12
This project follows young people prescribed estrogen to understand how it changes blood-clotting factors and how doctors decide on preventive care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $544,227 |
| NIH project number | 5R01HL161153-05 |
| Project ID | NIH-11418883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adolescents and young adults (and older adults as applicable) who are prescribed estrogen and have personal or family risk factors for thrombosis may be eligible.
✕Less likely to help
Patients without risk factors or those not initiating estrogen therapy may derive limited direct benefit.
What this research studies
Young patients starting estrogen will be followed to observe biological changes that might raise clot risk. Researchers will also survey and interview clinicians to learn what influences decisions about giving clot-prevention medicines. The study uses prospectively collected blood tests and clinical data to map risk patterns and inform future guidance for care. The goal is to reduce variations in practice and improve safety for youth on estrogen therapy.
Why it matters
Potential benefit: If successful, findings could help tailor safer estrogen use in youth and guide clinicians on when thromboprophylaxis might be appropriate.
How similar studies have gone: Prior work has explored thrombosis risk factors with estrogen in broader populations, but this project focuses specifically on youth and clinician decision-making, offering novel insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Mullins, Tanya L. Kowalczyk — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Mullins, Tanya L. Kowalczyk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.