Mitochondrial calcium in platelets and stroke risk
Official title: The role of mitochondrial calcium uniporter in platelet function and thrombosis
Funded at Washington University · NIH-11434662 · Data updated 2026-11-12
A grant is exploring how mitochondrial calcium channels in platelets affect clotting and stroke outcomes, with the goal of finding new ways to treat ischemic stroke patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $803,772 |
| NIH project number | 1R01HL188233-01 |
| Project ID | NIH-11434662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have experienced or are at risk of ischemic stroke, or who have acquired brain injury related conditions, may be eligible for related future studies or samples.
✕Less likely to help
People without stroke or platelet-related conditions may not directly benefit from this specific research.
What this research studies
This project looks at how the mitochondrial calcium uniporter in platelets influences platelet activation and clot formation in ischemic stroke. Researchers will study platelet signaling, procoagulant platelets, and interactions with immune cells to understand how MCU affects stroke pathology. The work combines human data from stroke patients with animal and cellular models to uncover potential targets for therapy.
Why it matters
Potential benefit: If successful, the findings could lead to new approaches to reduce harmful clotting in stroke patients and improve outcomes.
How similar studies have gone: Preliminary data suggest MCU influences platelet activation, but its exact role in stroke is still being explored and remains a promising but unproven target.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Campbell, Robert a — Washington University
- Study coordinator: Campbell, Robert a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.