Condition

Hemophilia B clinical trials and research

• 21Clinical trials
• 1NIH research projects
• 39Countries

Newest Hemophilia B clinical trials

All recruiting trials (21)

• SR604: a new treatment tested in adults with Hemophilia A/B or congenital Factor VII deficiency

  This study tests a single and multiple doses of SR604 to see if it is safe and effective for adults with Hemophilia A or B, with or without inhibitors, and for those with congenital Factor VII deficiency.

  Recruiting at 7 sites Phase 1/2 Shanghai RAAS Blood Products Co., Ltd. · Changsha and 8 other locations · NCT07644832

• Single-dose CSL222 gene therapy for adolescent males (12–17) with severe or moderately severe hemophilia B.

  This will give a single dose of CSL222 gene therapy to adolescent males with severe or moderately severe hemophilia B to see if it raises factor IX activity and reduces bleeding.

  Recruiting at 17 sites Phase 3 CSL Behring · Orange, California and 16 other locations · NCT07080905

• ATHNdataset registry for people with bleeding and clotting disorders

  This registry collects health, treatment, and patient-reported information from people with bleeding and clotting disorders seen at ATHN-affiliated centers to help improve care and outcomes.

  Recruiting American Thrombosis and Hemostasis Network · Hickory, North Carolina · NCT06820515

• Is synovial proliferation in haemophilia joints active or inactive?

  This project will test whether ultrasound, MRI and elastography can tell if subclinical synovial proliferation in people with severe haemophilia is currently active so clinicians can treat earlier.

  Recruiting UMC Utrecht · Utrecht · NCT06809972

• Observational study of blood clotting and bleeding disorders in Chinese patients

  This study looks at blood clotting and bleeding problems in Chinese patients to see how common they are and what factors might affect them.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality and 4 other locations · NCT06727669

• Comparing ANB-002 to standard treatment for hemophilia B

  This study is testing a new treatment called ANB-002 to see if it works as well as the standard treatment for adults with hemophilia B who have low FIX activity and no FIX inhibitors.

  Recruiting at 11 sites Phase 3 Biocad · Chelyabinsk and 13 other locations · NCT06700096

• Gene therapy for treating hemophilia B

  This study is testing a new gene therapy to see if it can help people with severe or moderately severe hemophilia B produce their own clotting factor IX and how safe it is for both adults and kids.

  Recruiting at 52 sites Phase 1/2 Regeneron Pharmaceuticals · Phoenix, Arizona and 51 other locations · NCT06379789

• Evaluating the safety and effects of SR604 in healthy individuals and those with Hemophilia A or B

  This study is testing a new drug called SR604 to see if it's safe and effective for healthy people and those with Hemophilia A or B.

  Recruiting at 8 sites Phase 1 Equilibra Bioscience LLC · Glendale, California and 9 other locations · NCT06349473

• Non-invasive prenatal diagnosis for single gene disorders

  This study is testing a new way to safely diagnose single-gene disorders in unborn babies using a simple blood test from the mother, starting as early as 9 weeks into the pregnancy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06147414

• Investigating ANB-002 for treating Hemophilia B

  This study is testing a new treatment called ANB-002 to see if it can safely help people with Hemophilia B manage their condition better.

  Recruiting at 17 sites Phase 1/2 Biocad · Homyel and 16 other locations · NCT06120582

• Observational study on the effectiveness and safety of HEMGENIX in hemophilia B patients

  This study is testing how well and safely HEMGENIX works for people with hemophilia B who are also getting Factor IX treatment.

  Recruiting at 12 sites CSL Behring · Rochester, New York and 11 other locations · NCT06008938

• Gene therapy for adults with Hemophilia B and specific antibodies

  This study is testing a new gene therapy called CSL222 to see if it can help adults with Hemophilia B who have certain antibodies reduce their bleeding risks.

  Recruiting at 32 sites Phase 3 CSL Behring · San Diego, California and 31 other locations · NCT06003387

• Gene therapy for teenagers with Hemophilia B

  This study is testing a new gene therapy for teenagers with Hemophilia B to see if a single treatment can help their bodies produce more of the factor IX protein they need.

  Recruiting Phase 1 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT05709288

• Evaluating ZS801 for treating Hemophilia B in adults

  This study is testing a new treatment called ZS801 to see if it can safely help adults with hemophilia B improve their blood-clotting factor levels.

  Recruiting Phase 1/2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT05641610

• Evaluating ZS801 for treating Hemophilia B in Chinese patients

  This study is testing a new treatment called ZS801 to see if it can help men with Hemophilia B manage their bleeding better.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT05630651

• Testing marstacimab for treating hemophilia in children

  This study is testing a new medication called marstacimab to see if it can help children with severe hemophilia control their bleeding and improve their health.

  Recruiting at 51 sites Phase 3 Pfizer · Salt Lake City, Utah and 62 other locations · NCT05611801

• Evaluating the safety and effectiveness of gene therapies for Hemophilia A and B

  This study is testing two gene therapies for Hemophilia A and B to see how safe and effective they are for patients who have already taken part in previous trials.

  Recruiting at 36 sites Phase 3 Pfizer · Rancho Cordova, California and 38 other locations · NCT05568719

• Long-term treatment with marstacimab for hemophilia patients

  This study is testing a long-term treatment called marstacimab to see if it can safely help people with severe hemophilia A or B manage their condition better.

  Recruiting at 68 sites Phase 3 Pfizer · Iowa City, Iowa and 77 other locations · NCT05145127

• Long-term study of blood diseases in patients in China

  This study is trying to gather detailed information from patients in China with blood diseases like leukemia and multiple myeloma to better understand how these conditions affect their lives and treatment options.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT04645199

• International registry for patients with hemophilia and bleeding disorders

  This study is collecting information from patients with hemophilia and bleeding disorders around the world to help improve treatment and understanding of these conditions.

  Recruiting World Federation of Hemophilia · Montreal, Quebec · NCT03327779

• Database for pediatric hemophilia treatment and outcomes

  This study is collecting information on how children with hemophilia A and B are treated and how it affects their lives to help improve their care and outcomes.

  Recruiting Goethe University · Frankfurt am Main, Hesse · NCT02912143

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Liver-directed gene delivery to restore clotting factor in hemophilia B and other inherited liver diseases

  This research uses a liver-targeted viral gene delivery approach to help adults with hemophilia B produce the missing clotting protein and could be applied to other inherited liver disorders.

  NIH research Stanford University · Stanford, United States · NIH-11257294

Related topics

Quick answers

How many Hemophilia B clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 39 countries. The most sites are in United States (9 trials), China (8 trials), Canada (7 trials), Australia (6 trials), France (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 1/2: 4, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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