Engineered nitric oxide releasing IV catheters with solid slippery surfaces to prevent infection and clotting
Official title: Engineering Nitric Oxide Releasing Intravascular Catheters with Solid Slippery Surfaces to Combat Infection and Thrombosis
Funded at Nytricx INC. · NIH-11313954 · Data updated 2026-11-12
A patient-facing overview of a new coating for short-term vascular access catheters that aims to lower risk of infection and blood clots.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nytricx INC. NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $314,337 |
| NIH project number | 1R43HL184590-01 |
| Project ID | NIH-11313954 on NIH RePORTER |
Who could benefit from this research
✓Could help
People requiring short-term vascular access devices (e.g., central venous or midline catheters) who may benefit from reduced infection and thrombosis risk.
✕Less likely to help
Patients not needing short-term vascular access or who already have well-protected catheters may see less direct benefit.
What this research studies
This project develops advanced catheter surfaces that steadily release nitric oxide and incorporate solid slippery coatings to resist bacteria and protein buildup. By combining NO release with slippery, low-friction surfaces, the approach aims to reduce infections and thrombosis in people who need short-term central lines. If successful, these coatings could extend catheter life and lower antibiotic use without requiring new patient procedures. The research involves translating lab findings into materials that could be used in human care with iterative testing and optimization.
Why it matters
Potential benefit: If successful, patients could experience fewer catheter-related infections and clots, potentially shorter hospital stays and less antibiotic exposure.
How similar studies have gone: Prior work shows NO-releasing materials can reduce infection and clotting; this project explores a robust solid slippery coating to enhance protection.
Where this research is happening
-
Nytricx INC.
Athens, United States Active
Researchers
- Principal investigator: Shebuski, Ronald J. — Nytricx INC.
- Study coordinator: Shebuski, Ronald J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.