Personalized blood-thinner plan for leg artery disease after repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study tests whether a TARGET plan that uses thromboelastography with platelet mapping (TEG-PM) to customize antiplatelet therapy improves outcomes after lower-extremity revascularization for PAD. Participants are randomized to the personalized plan or standard treatment and receive blood tests at 1 week and at 1, 3, 6, 9, and 12 months to guide medication adjustments. The study looks at whether the personalized approach reduces graft/stent thrombosis, amputation, repeat procedures, bleeding, and death over 12 months. TEG-PM provides real-time profiling of coagulation and platelet response to antiplatelet drugs to inform therapy changes. Preliminary data suggest significant variability in platelet inhibition among PAD patients, supporting the need for individualized thromboprophylaxis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with a named arterial extremity injury or named vessel revascularization for atherosclerosis requiring open and/or closed revascularization.
* Patients at the age of 18 or older

Exclusion Criteria:

* Patients who are younger than 18 years old
* Known pregnancy (females of childbearing potential will have a pregnancy test prior to surgery as per standard of care)
* Prisoners, defined as those who have been directly admitted from a correctional facility.
* No atherosclerosis
* Subject has active stomach ulcers
* Subject has severe hepatic impairment
* Subject has a recent history of intracranial hemorrhage. If the patient has a history of cerebral hemorrhage with no new central nervous system disease of \>1 year, the study team will consult with the

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• Salem Hospital (Mass General Brigham)
  Salem, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Anahita Dua, MBCHB, MBA, MSC
• Email: adua1@mgh.harvard.edu
• Phone: 262-565-8247

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.