Imaging blood clots in heart arteries to improve heart attack diagnosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate a new non-invasive imaging technique that can detect blood clots in the heart arteries, which are a common cause of acute myocardial infarction. By utilizing hybrid 18F-GP1 positron emission tomography and coronary computed tomography angiography, the study seeks to provide clearer insights into the underlying causes of heart attacks. The goal is to ensure patients receive accurate diagnoses and appropriate treatments, potentially improving their outcomes. The study will recruit 80 participants who meet specific clinical criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males and females ≥ 18 years of age
* Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria

Exclusion Criteria:

* \<18 years of age
* Takatsubo cardiomyopathy
* Myocarditis
* Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
* Woman of child-bearing potential who are pregnant or breastfeeding
* Known allergy or contraindication to iodinated contrast or radiotracer
* Patients unable to tolerate the supine position
* Patients unable to provide informed consent

Where it's running

• Royal Infirmary of Edinburgh
  Edinburgh, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.