Imaging blood clots in heart arteries to improve heart attack diagnosis
Non-invasive Coronary Thrombus Imaging to Define the Cause of Acute Myocardial Infarction
This study is testing a new imaging method to see if it can help doctors find blood clots in heart arteries to better diagnose heart attacks in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 1 site (Edinburgh) |
| Trial ID | NCT06113510 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate a new non-invasive imaging technique that can detect blood clots in the heart arteries, which are a common cause of acute myocardial infarction. By utilizing hybrid 18F-GP1 positron emission tomography and coronary computed tomography angiography, the study seeks to provide clearer insights into the underlying causes of heart attacks. The goal is to ensure patients receive accurate diagnoses and appropriate treatments, potentially improving their outcomes. The study will recruit 80 participants who meet specific clinical criteria.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older presenting with chest pain, elevated cardiac troponin levels, and non-obstructive coronary arteries.
Not a fit: Patients under 18, those with specific heart conditions like Takotsubo cardiomyopathy or myocarditis, and individuals with renal failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and tailored treatments for patients experiencing heart attacks.
How similar studies have performed: While this approach is innovative, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and females ≥ 18 years of age * Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria Exclusion Criteria: * \<18 years of age * Takatsubo cardiomyopathy * Myocarditis * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Woman of child-bearing potential who are pregnant or breastfeeding * Known allergy or contraindication to iodinated contrast or radiotracer * Patients unable to tolerate the supine position * Patients unable to provide informed consent
Where this trial is running
Edinburgh
- Royal Infirmary of Edinburgh — Edinburgh, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.