Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Official title: Local anti-inflammatory steroid therapy and molecular imaging to improve deep vein thrombosis (DVT)resolution and reduce the post-thrombotic syndrome (PTS)
Funded at Massachusetts General Hospital · NIH-11446647 · Data updated 2026-11-12
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $674,408 |
| NIH project number | 1R01HL182795-01A1 |
| Project ID | NIH-11446647 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with acute DVT who could participate in future trials or receive localized anti-inflammatory therapy.
✕Less likely to help
Patients with constraints that prevent catheter-based treatment or those unlikely to benefit from anti-inflammatory approaches may see no direct benefit.
What this research studies
This grant focuses on improving how DVT is treated by combining a local anti-inflammatory drug with catheter-based approaches and advanced imaging. Researchers will study how direct delivery of dexamethasone affects clot breakdown, vein wall scarring, and inflammation in mouse models, using PET/CT imaging to track inflammation. The goal is to find strategies that both help the clot dissolve and prevent the later problems like post-thrombotic syndrome. Results could guide new therapies that protect vein function after a DVT.
Why it matters
Potential benefit: If successful, patients with DVT could experience better clot resolution and fewer long-term vein complications.
How similar studies have gone: Previous studies suggest that targeting inflammation can influence clot resolution and vein healing, but mechanisms and imaging tracking remain areas of active investigation.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Jaffer, Farouc Amin — Massachusetts General Hospital
- Study coordinator: Jaffer, Farouc Amin
Related research
Other NIH-funded projects on the same topics.
-
Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
-
Oscillatory blood flow and vein valve health to prevent clots
Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.
-
Neutrophil integrin α9 and blood clots after stroke in aging
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
-
Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
-
Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
-
Understanding how blood clots in deep veins can lead to long-term complications
This study is looking into how deep vein thrombosis (DVT) affects healing and can lead to long-term problems like post-thrombotic syndrome (PTS), with the goal of finding better treatments for people dealing with these issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.