Computational modeling of platelets and blood flow to predict cerebral aneurysm treatment outcomes
Official title: Computational modeling of platelets and thrombosis in cerebral aneurysm treatment
Funded at University of Washington · NIH-11385494 · Data updated 2026-11-12
A researchers at UW are using computer models of blood flow and platelets to better predict whether an aneurysm treatment will work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $415,433 |
| NIH project number | 5R01NS105692-09 |
| Project ID | NIH-11385494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cerebral aneurysms undergoing treatment who are under consideration for planning and post-treatment follow-up.
✕Less likely to help
The research is primarily modeling-based and may not directly change care for every patient during the study period.
What this research studies
This project uses advanced computer simulations to combine how blood flows through brain vessels with how platelets and other blood factors might cause clotting after treatment. By merging Eulerian flow metrics with Lagrangian measures like platelet residence time, it aims to forecast treatment success or failure for cerebral aneurysms. The goal is to give clinicians better information before surgery to reduce the chance of recurrence or brain hemorrhage. The work builds on prior CFD modeling to create a holistic view of how treatments interact with the blood and vessels.
Why it matters
Potential benefit: If successful, patients could receive more accurate treatment plans and potentially fewer retreatments or complications.
How similar studies have gone: Earlier modeling efforts showed promise but require further validation with integrated blood-platelet metrics.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Levitt, Michael Robert — University of Washington
- Study coordinator: Levitt, Michael Robert
Related research
Other NIH-funded projects on the same topics.
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Modeling clotting and blood flow in brain aneurysm treatment
This project uses computer models of blood flow and platelets to predict clotting and treatment outcomes for people treated for brain aneurysms.
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Improving predictions for treating cerebral aneurysms using computer models
This study is working to improve computer models that help doctors understand blood flow and how platelets behave in brain aneurysms, so they can better predict how well treatments will work for patients like you.
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Improving predictions for treating cerebral aneurysms using computer models
This study is looking to improve computer models that help doctors understand blood flow and how platelets behave in brain aneurysms, so they can better predict how well treatments will work for patients like you.
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This study is looking at a protein called RIP3 in blood samples from people with aortic aneurysms to see how it affects blood clotting and could help us find new ways to treat this condition.
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WARRIORS: Should women with small abdominal aortic aneurysms get early repair or stay under surveillance?
A large international study is testing whether women with small abdominal aortic aneurysms should have early repair or watchful waiting, to see if earlier treatment improves survival and quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.