Piezo1’s role in blood clotting across vessels
Official title: Vascular Piezo1 in Thrombosis
Funded at Beth Israel Deaconess Medical Center · NIH-11451422 · Data updated 2026-11-12
Researchers are exploring how a tiny sensor in blood vessels called Piezo1 influences clot formation, with the aim of reducing clotting risks without causing dangerous bleeding.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 10, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $164,484 |
| NIH project number | 1K08HL181191-01A1 |
| Project ID | NIH-11451422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with thrombotic or bleeding risk conditions who may participate in future translational studies or related clinical trials, pending further validation.
✕Less likely to help
Patients without thrombotic or bleeding risk issues or those not eligible for future Piezo1-targeted approaches may not benefit.
What this research studies
This project looks at how mechanical forces in different vessels affect clotting through Piezo1. By using lab models and genetic tools, the team will see how Piezo1 activity changes thrombosis signals under varying flow conditions. The goal is to identify new targets that can fine-tune clotting locally rather than systemically. The work could pave the way for safer anticoagulant strategies that work with the body’s own flow cues.
Why it matters
Potential benefit: If successful, patients could benefit from safer anticoagulant therapies that minimize bleeding by targeting Piezo1-related pathways.
How similar studies have gone: Prior studies suggest Piezo1 influences coagulation pathways, supporting a potentially translateable approach, though this area is still emerging.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Sack, Kelsey — Beth Israel Deaconess Medical Center
- Study coordinator: Sack, Kelsey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.