Condition

Bleeding clinical trials and research

• 29Clinical trials
• 42NIH research projects
• 17Countries

Newest Bleeding clinical trials

All recruiting trials (29)

• Antiplatelet-Only versus Antiplatelet plus Low-Dose Rivaroxaban after Heart Events

  In adults 65 or older with prior heart events and certain arterial diseases, this study tests whether continuing clopidogrel alone is no worse than adding low-dose rivaroxaban to aspirin-based therapy.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07796217

• Multi-omics search for clotting and bleeding markers in coronary heart disease

  This project will test whether combining proteins, metabolites, genes, sugar tags, and heart images can better predict clotting and major bleeding in people with coronary heart disease on dual antiplatelet therapy.

  Recruiting at 3 sites Chinese Academy of Medical Sciences, Fuwai Hospital · Zhengzhou, Henan and 2 other locations · NCT07523880

• Apixaban vs Warfarin in HeartMate 3 LVAD Patients

  This study tests whether apixaban can replace warfarin to prevent clots and bleeding problems in adults with an implanted HeartMate 3 LVAD for at least 3 months.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07471139

• Safety of perioperative blood thinner management in people with cancer undergoing surgery or procedures

  This study tests how safe current practices are for stopping or continuing blood thinners in adults with cancer who are having surgery or procedures, to see if bleeding or clots are affected.

  Recruiting Ottawa Hospital Research Institute · Ottawa · NCT07372716

• Timing of hip fracture surgery for patients on DOAC blood thinners

  This project will see if operating within 24 hours is as safe as delaying surgery for people with hip fractures who recently took DOAC blood thinners by comparing how often they need blood transfusions.

  Recruiting at 7 sites St. Antonius Hospital · Almelo and 6 other locations · NCT07309848

• Emergency care for brain AVM bleeding using a hybrid neurosurgical operating room

  This study will test whether using a hybrid neurosurgical operating room that combines imaging, endovascular treatment, and microsurgery can provide faster one‑stop emergency care for adults (18–70) with acute brain arteriovenous malformation (AVM) bleeding.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07118631

• Intravenous iron for bleeding symptoms in iron-deficient people with inherited bleeding disorders

  This single-center study will try IV iron infusions to see if they reduce bleeding symptoms and improve quality of life for people over 15 with inherited bleeding disorders and low iron (ferritin <50 ng/mL).

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07083583

• Autologous Cold-Stored Platelets for Complex Cardiac Surgery

  This study tests whether using a patient’s own cold-stored platelets, donated 7–10 days before surgery, improves outcomes for adults undergoing complex cardiac procedures compared with standard allogeneic platelets.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario · NCT07064954

• FEIBA versus fresh frozen plasma as first-line treatment for bleeding after cardiac surgery

  This Phase 2 trial will test whether FEIBA works better than fresh frozen plasma (FFP) as the first treatment for adults who develop coagulopathic microvascular bleeding after non-emergency cardiac surgery with cardiopulmonary bypass.

  Recruiting Phase 2 Northwell Health · Manhasset, New York · NCT07032792

• Late bleeding after invasive gastrointestinal endoscopy in people taking anticoagulants versus those not on anticoagulants

  This study tries to see if adults on oral anticoagulants have more late bleeding after invasive gastrointestinal endoscopic procedures than adults who are not on anticoagulants.

  Recruiting Centro Cardiologico Monzino · Milan · NCT07019077

• How Bleeding Affects Delirium in Older Adults After Hip Fracture

  This trial tests whether early detection of bleeding and prompt blood transfusions can lower delirium risk in people 75 and older with hip fractures.

  Recruiting University of Aarhus · Aarhus, Central Jutland and 1 other locations · NCT06938789

• Best timing for heparin during radial-access coronary procedures

  This research will test whether giving heparin before inserting the radial sheath instead of after lowers the chance of radial artery occlusion in adults having radial-access coronary angiography or PCI.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT06890312

• Using Tranexamic Acid to Reduce Bleeding During Wisdom Tooth Removal

  This study is testing if using tranexamic acid during wisdom tooth removal can help reduce bleeding and swelling for healthy patients who need their impacted teeth taken out.

  Recruiting Bezmialem Vakif University · Istanbul, Fatih · NCT06806241

• Using tranexamic acid to reduce bleeding in major colorectal surgery

  This study is testing if giving tranexamic acid before major colorectal surgery can help reduce bleeding during and after the operation for patients.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06657924

• Evaluating aspirin use in heart failure patients with a heart pump

  This study is testing whether heart failure patients using a heart pump do better with or without aspirin in their blood-thinning treatment to see which option is safer and more effective.

  Recruiting at 3 sites Phase 4 Columbia University · Chicago, Illinois and 2 other locations · NCT06655376

• Comparing apixaban to no anticoagulant in surgery patients

  This study is testing if taking the blood thinner apixaban for 28 days after abdominal or pelvic surgery can help prevent blood clots in patients who are at risk.

  Recruiting Phase 4 Clinical Urology and Epidemiology Working Group · Helsinki · NCT06523959

• Injection of Bupivacaine and Epinephrine for Sinus Surgery

  This study is testing if injecting a mix of bupivacaine and epinephrine during sinus surgery can help doctors see better and reduce bleeding compared to a fake injection.

  Recruiting Phase 2/3 St. Paul's Hospital, Canada · Vancouver, British Columbia · NCT06456255

• Comparing blood thinners for patients on ECMO support

  This study is testing whether two different blood thinners, argatroban and enoxaparin, can work as well as the usual treatment, heparin, for patients on ECMO support.

  Recruiting Phase 4 Medical University of Vienna · Vienna, State of Vienna · NCT06442267

• Reducing surgical bleeding in adults with advanced or acute kidney disease

  This trial will test whether giving tranexamic acid or desmopressin before noncardiac surgery reduces bleeding in adults with advanced chronic kidney disease or recent acute kidney injury, including those on dialysis.

  Recruiting at 2 sites Phase 3 Hamilton Health Sciences Corporation · London, Ontario and 2 other locations · NCT06337838

• Using stem cell exosomes to help recover from chemotherapy side effects in leukemia patients

  This study is testing if giving leukemia patients special stem cell treatments can help them recover better from the side effects of chemotherapy.

  Recruiting Phase 1 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06245746

• Using tranexamic acid to reduce bleeding during brain tumor surgery

  This study is testing if giving tranexamic acid during brain tumor surgery can help reduce bleeding and improve safety for patients.

  Recruiting Phase 3 Nova Scotia Health Authority · Halifax, Nova Scotia · NCT06229483

• Evaluating Nafamostat Mesylate for Dialysis Patients at High Risk of Bleeding

  This study is testing if Nafamostat Mesylate can be a safer blood thinner than heparin for dialysis patients who are at high risk of bleeding.

  Recruiting Wonju Severance Christian Hospital · Wŏnju, Kangwondo · NCT05874674

• Comparing preoperative and postoperative blood clot prevention in pancreatic surgery

  This study is testing whether giving blood clot prevention medication before or after pancreatic surgery works better to keep patients safe from clots.

  Recruiting at 5 sites Phase 4 Helsinki University Central Hospital · Toronto and 4 other locations · NCT05245877

• Quick balloon dilation for removing large bile duct stones

  This study is testing if a quick balloon method can help adults get rid of large bile duct stones safely and effectively.

  Recruiting at 2 sites Helsinki University Central Hospital · Helsinki and 1 other locations · NCT05061680

• Comparing preoperative and postoperative blood clot prevention for liver surgery

  This study is testing whether giving blood clot prevention medicine before or after liver surgery works better to keep patients safe from clots.

  Recruiting at 5 sites Phase 4 Helsinki University Central Hospital · Helsinki and 6 other locations · NCT04731558

• Enhancing platelet function to reduce bleeding

  This study is testing if a treatment called Wilate® can help patients in the ICU who are bleeding by improving their platelet function and reducing the need for blood transfusions.

  Recruiting Phase 4 University Hospital, Basel, Switzerland · Basel · NCT04555785

• Optimal antithrombotic strategy for patients with atrial fibrillation undergoing PCI

  This study is testing whether a new blood-thinning treatment for patients with atrial fibrillation undergoing heart procedures is safer and just as effective as the traditional approach that includes more medications.

  Recruiting at 18 sites Phase 4 St. Antonius Hospital · Aalst and 19 other locations · NCT04436978

• Comparing clinical surveillance to anticoagulation for low-risk patients with isolated pulmonary embolism

  This study is testing whether low-risk patients with isolated pulmonary embolism can safely be monitored without blood thinners instead of taking them.

  Recruiting at 29 sites Phase 4 Insel Gruppe AG, University Hospital Bern · Woluwe-Saint-Lambert, Brussels Capital and 39 other locations · NCT04263038

• Evaluating anticoagulation for new atrial fibrillation after heart surgery

  This study is testing if adding a blood thinner to regular heart medication can help patients who develop new atrial fibrillation after heart surgery, while also keeping an eye on any bleeding risks.

  Recruiting at 63 sites Phase 3 Icahn School of Medicine at Mount Sinai · Little Rock, Arkansas and 105 other locations · NCT04045665

NIH-funded research (newest 40 of 42)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Direct measurement of RhD sensitization after early-pregnancy bleeding

  This study tests how often Rh immunoglobulin given after bleeding in early pregnancy prevents RhD sensitization in pregnant people.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11413670

• EpiMAX: a new injectable gel that stops GI bleeding quickly and for days

  A new injectable hydrogel with epinephrine-loaded microparticles is designed to plug GI bleeds and provide immediate and lasting hemostasis for about 72 hours.

  NIH research Origin Endoscopy INC. · Baltimore, United States · NIH-11407431

• Dynamic risk tools to prevent blood clots and bleeding in cancer patients

  A new AI-based approach will predict who among people with cancer starting treatment is at higher risk for blood clots or dangerous bleeding, helping doctors tailor preventive care.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11402709

• Bleeding and Platelet Problems in Ehlers-Danlos Syndrome

  This NIH grant looks at why people with Ehlers-Danlos syndrome bleed more and how platelet function is involved, with goals that could lead to better care during surgery or emergencies.

  NIH research University of Iowa · Iowa City, United States · NIH-11401685

• Long-acting RNA therapy to control fibrinolysis and reduce bleeding

  A new RNA treatment delivered in lipids aims to slow down fibrinolysis and lessen bleeding for people with bleeding disorders or severe hemorrhage.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11380066

• Thrombosis and Bleeding Risk in Medical Inpatients

  A patient-facing program to better predict who is at risk for blood clots or bleeding during and after hospital stays, and to tailor prevention accordingly.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11366383

• Heavy menstrual bleeding treatment for adolescents with bleeding disorders

  A multicenter study will compare two progestin-based treatments for heavy periods in teens and young adults with bleeding disorders to see which helps reduce bleeding and improves well-being.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11361137

• Multiscale computer modeling to predict bleeding risk from blood-contacting heart devices

  A computer model will predict how heart devices that touch blood cause bleeding by affecting von Willebrand factor and platelets, aiming to guide safer device design.

  NIH research Lawrence Technological University · Southfield, United States · NIH-11360751

• Understanding why some people with factor XI deficiency bleed more than others

  A doctor-scientist team is studying why people with low factor XI have very different bleeding risks and is looking for ways to better predict who might bleed.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11332657

• Why people with LVADs bleed: the role of von Willebrand factor and blood-vessel changes

  Researchers will compare blood and vessel changes in people with left ventricular assist devices (LVADs) to find how a clotting protein called von Willebrand factor (VWF) and high blood flow forces lead to bleeding.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11320841

• Commercialization of an intravenous hemostatic nanoparticle for bleeding management

  A new nanoparticle-based treatment called SynthoPlate could help stop dangerous bleeding across many situations, from accidents to surgeries, by mimicking how natural platelets work.

  NIH research Haima Therapeutics, LLC · Cleveland, United States · NIH-11313383

• Anti-microbial platelet-like particles to stop bleeding and boost healing

  A new platelet-like particle treatment is being developed to quickly stop bleeding after trauma and help wounds heal better, especially in severe injuries and brain injuries.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11310844

• New treatment to reduce bleeding in patients with low platelet counts

  This study is testing a new type of treatment that uses tiny particles to help people with low platelet counts, like those undergoing chemotherapy or dealing with autoimmune disorders, by providing a better way to prevent excessive bleeding.

  NIH research Haima Therapeutics, LLC · Cleveland, United States · NIH-11285688

• How blood-contacting devices affect platelets, clots, and bleeding

  They are creating computer models to understand why heart pumps and other blood-contacting devices can make platelets trigger clots or bleeding in people who use them.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11238491

• Bleeding risk from blood thinners in people with cancer

  This project will build a tool to predict how likely people with cancer are to have serious bleeding while taking blood thinners.

  NIH research Washington University · Saint Louis, United States · NIH-11237616

• Rapid blood-stopping adhesive for surgery and patients on blood thinners

  A sticky, biocompatible paste designed to stop surgical bleeding within seconds, including for people taking blood thinners or with bleeding disorders.

  NIH research Sanaheal, INC. · Somerville, UNITED STATES · NIH-11196760

• Treating Heavy Periods in People with Bleeding Disorders

  This project compares two hormone treatments to help young people with bleeding disorders manage heavy periods and improve their quality of life.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11193531

• Understanding bleeding issues in acute promyelocytic leukemia

  This study is looking into why people with acute promyelocytic leukemia often have serious bleeding problems, using special mouse models to help understand the blood issues they face, with the hope of finding better ways to help patients manage these complications.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11175769

• A New Long-Lasting RNA Treatment for Bleeding Disorders

  This work explores how blood clot breakdown contributes to bleeding and aims to create a new, long-acting RNA medicine to help people with bleeding disorders.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11132938

• Treating Bleeding and Improving Life Quality in Hereditary Hemorrhagic Telangiectasia

  This project explores if a medication called bevacizumab can help adults with Hereditary Hemorrhagic Telangiectasia (HHT) by reducing bleeding and improving their daily lives.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11109583

• Sprayable hydrogel sealant to prevent gut bleeding

  This project is developing a sprayable, biodegradable glue doctors could use during endoscopy to seal mucosal wounds and lower the chance of bleeding after procedures like polyp removal.

  NIH research Biodevek INC · Cambridge, UNITED STATES · NIH-11092336

• Blood-safe ECMO tubing using a special coating plus a targeted clotting blocker

  A special surface coating plus a targeted clotting blocker aims to stop blood clots in ECMO machines without causing dangerous bleeding for people on life support with severe lung failure.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11091479

• Using platelet-like particles to stop bleeding and improve healing

  This study is looking at a new treatment using tiny particles that act like platelets to help stop bleeding and heal wounds better for people who have been injured, especially those at risk of bleeding too much or getting infections.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11090495

• Understanding bleeding risks in people with factor XI deficiency

  This study is looking into why some people with factor XI deficiency bleed more than others, and it aims to create better tests to help predict who might be at risk, so that treatments can be improved for those affected.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11089557

• Investigating bleeding issues related to heart support devices

  This study is looking at why some patients with advanced heart disease who use heart pumps (LVADs) have problems with bleeding, and it hopes to find ways to help these patients feel better and stay healthier.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11080772

• A new paste to quickly stop bleeding without relying on blood clotting

  This study is working on a special paste that helps stop bleeding quickly for patients who take blood thinners or have bleeding disorders, making it safer for them during surgeries.

  NIH research Sanaheal, INC. · Somerville, UNITED STATES · NIH-11007752

• Understanding joint bleeding in people with hemophilia

  This study looks at how bleeding in the joints affects how people with hemophilia move, using special technology to measure their movements, so we can help them make safer choices for staying active and reduce the chances of future bleeding.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11005040

• Using electronic health records to identify complications after heart procedures

  This study is working on a smart way to spot problems that can happen after a common heart procedure called PCI, using computer programs to look at health records, so that doctors can better keep you safe and provide the best care possible.

  NIH research Yale University · New Haven, United States · NIH-11001500

• Investigating the causes of bleeding in the brain related to amyloid buildup

  This study is looking at how a buildup of a protein in the brain's blood vessels can cause bleeding and other problems, especially in older adults, to help find better ways to prevent these issues for people with this condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10991800

• Modeling how medical devices affect blood platelets and bleeding risks

  This study is looking at how certain medical devices that come into contact with your blood can affect platelets, which are important for clotting, and it aims to find ways to make these devices safer for patients like you.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10986121

• Understanding bleeding risks from blood thinners in cancer patients

  This study is looking to create a helpful tool that can predict which cancer patients on blood thinners might be at risk for serious bleeding, so doctors can make safer choices about their treatment.

  NIH research Washington University · Saint Louis, United States · NIH-10983348

• Using AI to improve risk assessment for patients with acute gastrointestinal bleeding

  This study is working on a new tool that uses advanced technology to help doctors better understand the risk of patients having sudden stomach bleeding, so they can make smarter decisions about who needs to be hospitalized and when.

  NIH research Yale University · New Haven, United States · NIH-10918333

• Investigating a new RNA therapy to reduce bleeding by controlling fibrinolysis

  This study is looking at how a process that breaks down blood clots can lead to too much bleeding in people with bleeding disorders, and it aims to help these patients by using special RNA treatments that could make bleeding easier to manage.

  NIH research Versiti Wisconsin, INC. · Milwaukee, United States · NIH-10907802

• Investigating bleeding risks in women who are carriers of Hemophilia A

  This study is looking at why some women who carry Hemophilia A experience unusual bleeding, even when their blood tests seem normal, and it aims to create a tool to help predict their bleeding risk so they can get better care.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10907656

• Identifying and preventing blood clots in hospitalized children

  This study is looking to find out which hospitalized kids are most likely to develop blood clots, so we can better prevent them and keep kids safe during their hospital stay.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10892650

• Using antiangiogenic therapy to reduce bleeding in patients with hereditary hemorrhagic telangiectasia

  This study is looking at whether a medication called bevacizumab can help people with hereditary hemorrhagic telangiectasia (HHT) by reducing bleeding episodes and making their lives better.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10886041

• Investigating how aging affects bleeding risk in von Willebrand disease

  This study is looking at how age affects bleeding risk in adults with von Willebrand disease, and it aims to help improve care for people living with this condition by understanding their bleeding tendencies better.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10877727

• Understanding differences in care and outcomes for patients with gastrointestinal bleeding

  This study is looking at how different hospitals treat patients with gastrointestinal bleeding to find ways to improve care and outcomes, so that everyone gets the best help possible no matter where they go.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10833004

• Improving blood flow measurement in patients with cirrhosis to prevent dangerous bleeding

  This study is testing a new, safe MRI method to check blood flow in people with cirrhosis, helping to spot dangerous varices without needing any invasive procedures, so patients can avoid the risks of traditional monitoring.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10747919

• Investigating the role of tissue factor in bleeding and clotting risks

  This study is looking at how a protein called tissue factor affects bleeding and clotting problems, and it's for people who have conditions like heart attacks or strokes, with the goal of finding better ways to understand and manage these issues.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10695220

Related topics

Quick answers

How many Bleeding clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in Canada (8 trials), United States (6 trials), Finland (4 trials), Netherlands (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 9, Phase 3: 4, Phase 2/3: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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