Role of blood group antigens in how platelets help or hinder bleeding and clots
Official title: Defining the Role of Platelet ABO(H) Blood Group Antigens in Hemostasis and Thrombosis
Funded at Brigham and Women's Hospital · NIH-11325438 · Data updated 2026-11-12
A study at Brigham and Women’s Hospital will look at how ABO blood group sugars on platelets affect bleeding risk and clotting risk in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $426,023 |
| NIH project number | 5R00HL177820-02 |
| Project ID | NIH-11325438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with different ABO blood types who participate in platelet studies or provide blood samples.
✕Less likely to help
People not contributing blood samples or without interest in platelet testing or blood type-related risk may not benefit.
What this research studies
This project investigates why blood type may influence bleeding and clotting by focusing on platelets and their surface antigens. Researchers will compare how platelets from people with different ABO types interact with key clotting factors using ELISA and binding measurements. The goal is to understand whether ABO(H) sugars on platelet proteins change the way platelets stick to Von Willebrand Factor and related molecules. Findings could reveal mechanisms behind why some people bleed more or form clots more readily, guiding future treatments.
Why it matters
Potential benefit: If successful, this work could lead to better risk assessment and tailored therapies for bleeding or clotting disorders based on a patient’s blood type.
How similar studies have gone: Previous studies have linked ABO type to bleeding and clotting risk, but the exact platelet mechanisms are not yet defined, making this approach novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hollenhorst, Marie — Brigham and Women's Hospital
- Study coordinator: Hollenhorst, Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.