Neutrophil integrin α9 and blood clots after stroke in aging
Official title: Mechanisms for Deep Vein Thrombosis following Stroke
Funded at Louisiana State Univ Hsc Shreveport · NIH-11396538 · Data updated 2026-11-12
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $435,343 |
| NIH project number | 5R01HL158546-05 |
| Project ID | NIH-11396538 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have had an acute ischemic stroke, especially older adults, may be eligible to contribute samples or participate in related studies.
✕Less likely to help
If you have not had a stroke or are not in the target age range, direct benefits may be limited.
What this research studies
If you’ve had a stroke and are aging, you’re at higher risk for blood clots in the legs and lungs. Researchers will study how the protein integrin α9 on neutrophils contributes to clot formation after stroke and aging, using human data and animal models. They’ll explore whether blocking this pathway could reduce clot risk without causing excessive bleeding. The study aims to uncover new ideas for safer prevention alongside standard anticoagulants.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that lower post-stroke clot risk with fewer bleeding side effects.
How similar studies have gone: Previous work suggests neutrophils and α9 integrin are involved in clot formation, with promising signals in early studies.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Dhanesha, Nirav — Louisiana State Univ Hsc Shreveport
- Study coordinator: Dhanesha, Nirav
Related research
Other NIH-funded projects on the same topics.
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Understanding how stroke increases the risk of blood clots in veins
This study is looking at how certain white blood cells and a specific protein might cause blood clots in older adults who have had a stroke, with the goal of finding safer ways to prevent these clots from forming.
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Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
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Oscillatory blood flow and vein valve health to prevent clots
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Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
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Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
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Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.