Understanding why some CKD patients have more blood clots after vascular procedures
Official title: Disease-specific risk factors for thrombosis following vascular interventions
Funded at Boston Medical Center · NIH-11378494 · Data updated 2026-11-12
This NIH grant explores why people with chronic kidney disease are more prone to blood clots after vascular interventions and how to prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $660,794 |
| NIH project number | 5R01HL166608-04 |
| Project ID | NIH-11378494 on NIH RePORTER |
Who could benefit from this research
✓Could help
CKD patients undergoing or needing vascular interventions (e.g., angioplasty or vascular surgery)
✕Less likely to help
Patients without CKD or those not undergoing vascular interventions may not directly benefit
What this research studies
The project focuses on CKD patients who need procedures like angioplasty or vascular surgery and howuremic toxins may drive clotting. Researchers will look at human-relevant pathways and use models to study tissue factor and other coagulation changes after interventions. The aim is to identify targets that could reduce post-procedure clots and improve safety for CKD patients. Results could guide new treatments or strategies to lower complication risks after vascular care.
Why it matters
Potential benefit: If successful, this work could lead to safer vascular procedures for CKD patients by reducing post-procedure thrombosis risk.
How similar studies have gone: Prior data show a link between uremic toxins and prothrombotic changes, supporting this line of investigation
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Chitalia, Vipul C — Boston Medical Center
- Study coordinator: Chitalia, Vipul C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.