Endothelial TSP1 and anti-thrombotic protection in DVT
Official title: Regulatory Mechanisms of the Vessel Wall in Thrombosis
Funded at University of Wisconsin-Madison · NIH-11431068 · Data updated 2026-11-12
A research team at UW–Madison is studying how a protein on blood vessel linings, TSP1, helps prevent clots in veins and what happens when it’s missing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $743,131 |
| NIH project number | 1R01HL187968-01 |
| Project ID | NIH-11431068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with or at risk for deep vein thrombosis and who could benefit from new anti-clot strategies in the future.
✕Less likely to help
Patients not at risk for DVT or those whose condition is unrelated to endothelial TSP1 signaling may not benefit.
What this research studies
The project uses a mouse model of deep vein thrombosis to explore how endothelial cells control clotting, focusing on thrombospondin-1 (TSP1) and its effect on inflammation and oxygen-sensing pathways. Researchers will test whether blocking or boosting HIF1α signaling can reverse the worsened clotting seen when endothelial TSP1 is deleted, and they will study these mechanisms in human iPSC-derived endothelial cells. The study combines animal experiments with cellular models to map the signaling pathway that keeps veins from forming dangerous clots. If successful, this work could reveal new targets to reduce clots without increasing bleeding risk.
Why it matters
Potential benefit: Understanding endothelial TSP1’s protective role could lead to safer anticoagulant strategies that minimize bleeding.
How similar studies have gone: Previous approaches using endothelial signaling pathways have shown promise in reducing thrombosis without excessive bleeding, but this specific TSP1–HIF1α axis is novel.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Zhou, Ting — University of Wisconsin-Madison
- Study coordinator: Zhou, Ting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.