Condition

Sickle Cell Disease clinical trials and research

• 124Clinical trials
• 215NIH research projects
• 41Countries

Newest Sickle Cell Disease clinical trials

All recruiting trials (124)

• Cerebrovascular Reactivity Testing with HD-DOT in Sickle Cell Patients

  This study tests whether high-density diffuse optical tomography can measure brain blood flow and oxygen use in people with sickle cell disease, to see how these signals relate to stroke risk.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07776444

• Adapting and testing PEN-Plus in Zambian primary care

  Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

  Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

• Newborn Sickle Cell Screening in Mozambique

  We’re testing a three-part plan to help babies in Mozambique get diagnosed early for sickle cell disease and start care quickly.

  Recruiting St. Jude Children's Research Hospital · Nhamatanda, Sofala · NCT07719972

• Optimizing Hydroxyurea in Children with Sickle Cell in Africa

  This study tests whether raising hydroxyurea to a maximum tolerated dose is safe and beneficial for Ugandan children with sickle cell anemia already taking a fixed daily dose.

  Recruiting Phase 1/2 Children's Hospital Medical Center, Cincinnati · Kampala · NCT07708714

• Hematopoietic stem cell editing to treat sickle cell disease

  This study tests whether a patient’s own blood stem cells can be edited to remove the sickle cell triggering gene and then returned to the patient.

  Recruiting Phase 1 Boston Children's Hospital · Boston, Massachusetts · NCT07708350

• Virtual reality options to help with VOC pain in adults with SCD

  This study tests whether headset-based virtual reality can help reduce pain for adults with sickle cell disease during vaso-occlusive crises treated in an infusion center.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT07674277

• Mitapivat for reducing transfusion needs in sickle cell disease

  This study tests whether mitapivat, compared with placebo, can lower the number of blood transfusions needed by people with sickle cell disease.

  Recruiting at 5 sites Phase 3 Agios Pharmaceuticals, Inc. · Indianapolis, Indiana and 4 other locations · NCT07656415

• Haploidentical donor transplant for sickle cell disease in young patients

  This trial tests a gentler conditioning regimen and a post-transplant medication plan to see if children and young adults with sickle cell disease can have a successful haploidentical hematopoietic cell transplant with limited GVHD.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07616154

• SCD SIMCS: a mobile system to help screen newborns for sickle cell disease in Ugandan clinics

  A cluster randomized trial will test a mobile information system (SIMCS) that helps health workers screen newborns for sickle cell disease and coordinate care, compared with usual screening in Uganda.

  Recruiting Makerere University · Jinja · NCT07610239

• Partial stem cell transplant for sickle cell disease and beta-thalassemia using matched donors

  This study tests a partial stem cell transplant from matched donors to help people with severe sickle cell disease or beta-thalassemia see if more donor cells can persist long-term.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07599176

• Music therapy for pain and quality of life in youth with sickle cell disease

  This study tests whether a 4-week music therapy program can reduce pain and improve well-being in young people with sickle cell disease.

  Recruiting Emory University · Atlanta, Georgia · NCT07562451

• Hydroxyurea Use in Sickle Cell Disease: Personalizing Dose in Nigerian Patients

  This observational study tests how genetic, pharmacokinetic, and pharmacodynamic differences affect hydroxyurea response in Nigerian people with sickle cell disease to help tailor dosing.

  Recruiting Obafemi Awolowo University · Ile-Ife, Osun State · NCT07543289

• SickleFit: exercise and nutrition program for adults with sickle cell disease

  This program will test whether a personalized exercise plan plus dietitian-guided nutrition helps adults aged 35 and older with sickle cell disease feel and function better.

  Recruiting Duke University · Durham, North Carolina · NCT07442851

• Gene therapy using corrected β-globin and a silencing RNA in your own CD34+ stem cells for severe sickle cell disease

  This trial will try a one-time gene therapy using a patient’s own modified CD34+ stem cells to reduce painful vaso-occlusive crises and long-term organ damage in people aged 12–35 with severe sickle cell disease.

  Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07432867

• Ovarian reserve during puberty in girls with sickle cell disease

  This project will test whether AMH blood levels, a marker of ovarian reserve, differ during puberty in girls aged 10 to <19 with sickle cell disease compared with healthy girls.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07392216

• Long-term follow-up after BEAM-101 treatment

  This follow-up will see how people with sickle cell disease who received BEAM-101 are doing over 15 years.

  Recruiting Beam Therapeutics Inc. · Birmingham, Alabama and 16 other locations · NCT07373639

• Low-dose ketamine for sickle cell vaso-occlusive pain in children and young adults

  This trial will test whether adding a low (sub-dissociative) dose ketamine infusion to usual IV opioid pain medicine helps children and young adults (ages 5–20) with sickle cell disease have better pain relief and remain safe during a vaso-occlusive episode.

  Recruiting Phase 2 Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, California · NCT07369024

• Checking measles vaccine response in children with sickle cell disease

  This study tests whether infants and young children with sickle cell disease develop enough protection in the weeks after their measles vaccine.

  Recruiting at 3 sites Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio and 2 other locations · NCT07356050

• Mindfulness and stress-management program for adults with sickle cell disease

  This program will try a six-week mindfulness and stress-management course to see if it improves quality of life for adults with sickle cell disease who live near Philadelphia.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07316478

• Senicapoc for Sickle Cell Disease with Hemolytic Phenotype

  A mid-stage study tests whether daily senicapoc helps people with sickle cell disease who have ongoing red blood cell breakdown and low hemoglobin, despite hydroxyurea, by comparing it to a placebo over 24 weeks.

  Recruiting at 4 sites Phase 2 Biossil Inc. · Toronto, Ontario and 3 other locations · NCT07282210

• Ruxolitinib-enhanced haploidentical transplant for children and young adults with sickle cell disease

  This trial will test whether adding ruxolitinib to a reduced-intensity haploidentical transplant lowers the risk of graft failure in children and young adults with sickle cell disease.

  Recruiting Phase 1/2 Arkansas Children's Hospital Research Institute · Aurora, Colorado and 3 other locations · NCT07252050

• Single-dose 21-valent pneumococcal conjugate vaccine for children and teens with sickle cell disease

  This trial tests whether a single dose of the new PCV21 vaccine is safe and helps children and teens (ages 2–17) with sickle cell disease make protective antibodies compared with the licensed 20-valent pneumococcal vaccine.

  Recruiting at 7 sites Phase 3 Sanofi · Atlanta, Georgia and 6 other locations · NCT07247188

• Morphine removal and kidney filtering in adults with sickle cell crises in intensive care

  This project will test how quickly morphine is cleared from the body in adults with sickle cell disease admitted to intensive care for vaso-occlusive crisis or acute chest syndrome, and whether faster kidney filtering leads to lower morphine levels.

  Recruiting University Hospital, Tours · Tours, France and 5 other locations · NCT07246265

• Methylphenidate for attention and executive problems in children with sickle cell disease

  This study will test whether once-daily extended-release methylphenidate for 4 weeks helps attention and thinking skills in children 8–17 with sickle cell disease while monitoring side effects and adherence.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07226219

• Testing Anumigilimab (CSL324) safety in adults with sickle cell disease

  This study will test whether subcutaneous Anumigilimab is safe for adults with sickle cell disease who had 1–12 painful vaso-occlusive crises in the past year.

  Recruiting at 38 sites Phase 2 CSL Behring · Little Rock, Arkansas and 37 other locations · NCT07224360

• Songwriting to Reduce Anxiety in Teens with Sickle Cell Disease

  This program will try songwriting and performing original songs to see if it helps reduce anxiety in adolescents (ages 11–18) with sickle cell disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07222475

• Integrated diagnosis for sickle cell disease and other rare anemias

  This project tests whether combining genetic testing, LoRRca ektacytometry, and microfluidic analysis can improve diagnosis and predict disease course for people with sickle cell disease and other inherited anemias.

  Recruiting at 4 sites Hospital Universitari Vall d'Hebron Research Institute · Barcelona and 3 other locations · NCT07206095

• DISC-3405 for adults with sickle cell disease

  This will test DISC-3405 in adults with sickle cell disease who have had recent pain crises or other complications to see if it is safe and how the body handles it.

  Recruiting at 11 sites Phase 1 Disc Medicine, Inc · Birmingham, Alabama and 10 other locations · NCT07187973

• Trans-auricular nerve stimulation for pain in children with sickle cell disease

  This trial will test whether gentle electrical stimulation of nerves at the outer ear can reduce pain in children with sickle cell disease who are hospitalized for pain crises.

  Recruiting Emory University · Atlanta, Georgia · NCT07090668

• Bone health, muscle strength, and frailty in postmenopausal women of African descent with sickle cell trait

  We will see if postmenopausal women of African descent who have sickle cell trait are more likely to have thinner bones, weaker muscles, or greater frailty than women without the trait.

  Recruiting UConn Health · Farmington, Connecticut · NCT07083531

• Early heart screening and treatment for people with sickle cell disease

  This study tests whether regular heart checks and early iron-removing treatment can prevent heart problems and cut hospital stays in adults with sickle cell disease who have high iron or heart symptoms.

  Recruiting at 2 sites Phase 2 Inova Health Care Services · Fairfax, Virginia and 1 other locations · NCT07023666

• EMDR to reduce pain interference in children with sickle cell disease

  This will test EMDR therapy to see if it reduces how much pain gets in the way of daily life for children and adolescents (6–18) with sickle cell disease.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07001631

• Regional anesthesia to reduce inflammation during vaso‑occlusive crises in sickle cell disease

  This project will test whether giving regional (loco‑regional) anesthesia to adults hospitalized for sickle cell vaso‑occlusive crises reduces inflammatory markers and speeds recovery compared with usual care.

  Recruiting Centre Hospitalier Universitaire de la Guadeloupe · Pointe-à-Pitre · NCT07001189

• Why dengue is more severe in people with sickle cell disease

  This project will test whether immune cells and tiny blood particles from young people with SC or SS sickle cell disease respond differently to dengue virus compared with healthy controls, which could explain more severe infections.

  Recruiting Centre Hospitalier Universitaire de la Guadeloupe · Pointe-à-Pitre · NCT07000747

• Evaluating Rilzabrutinib for Sickle Cell Disease in Patients Aged 10 to 65

  This study is testing a new medication called rilzabrutinib to see if it can help people aged 10 to 65 with sickle cell disease have fewer pain crises and improve their overall health.

  Recruiting at 63 sites Phase 3 Sanofi · Birmingham, Alabama and 62 other locations · NCT06975865

• Understanding genetic risks of immune responses after blood transfusions in sickle cell disease

  This study is trying to find out how genetics affect the immune response to blood transfusions in people with sickle cell disease to help improve their treatment.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06944067

• Cannabidiol (CBD) treatment for adults with sickle cell disease

  This trial will try three doses of oral cannabidiol taken twice daily for 4 weeks in adults with sickle cell disease, compared with placebo, to see if it lowers inflammation and pain-related measures.

  Recruiting Phase 1/2 Icahn School of Medicine at Mount Sinai · Manhattan, New York · NCT06930703

• Evaluating the safety and effectiveness of Xromi in young children with sickle cell disease

  This study is testing if the medication Xromi is safe and effective for young children with sickle cell disease.

  Recruiting at 12 sites Nova Laboratories Limited · Hamburg and 11 other locations · NCT06923111

• Mobile app plus printed booklets to help adults manage sickle cell disease

  This project will test whether a mobile app combined with printed patient-facing sickle cell guidelines helps adults with sickle cell disease use less emergency and hospital care than printed booklets alone.

  Recruiting at 4 sites Ohio State University · Chicago, Illinois and 3 other locations · NCT06919224

• Donor transplant for high risk blood disorders

  This study is testing if a stem cell transplant from a matched sibling can help people with high-risk blood disorders like sickle cell disease and thalassemia feel better.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT06872333

• Using music therapy to improve quality of life in sickle cell disease

  This study is testing if music therapy can help improve the quality of life for teenagers and adults with sickle cell disease.

  Recruiting University of California, Irvine · Cleveland, Ohio and 1 other locations · NCT06853158

• Endurance training for patients with sickle cell disease

  This study is testing whether a long-term endurance training program can help improve health, fitness, and quality of life for both adults and children with sickle cell disease.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06823219

• ATHNdataset registry for people with bleeding and clotting disorders

  This registry collects health, treatment, and patient-reported information from people with bleeding and clotting disorders seen at ATHN-affiliated centers to help improve care and outcomes.

  Recruiting American Thrombosis and Hemostasis Network · Hickory, North Carolina · NCT06820515

• Tocilizumab for Acute Chest Syndrome in Sickle Cell Disease

  This study tests whether a single infusion of tocilizumab can help people with sickle cell disease and acute chest syndrome come off oxygen and respiratory support faster.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06818266

• Using virtual reality to help manage pain in children with sickle cell disease

  This study tests if using virtual reality can help children with sickle cell disease feel less pain during their hospital stays compared to just standard pain management.

  Recruiting Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT06773715

• Digital cognitive rehabilitation for youth with sickle cell disease

  This study is testing a digital program that helps kids and teens with sickle cell disease improve their thinking skills and memory while also providing social support.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06770010

• Improving lung function in sickle cell disease with acupuncture-like stimulation

  This study is testing whether combining breathing exercises with a special type of electrical stimulation can help improve lung function in people with sickle cell disease.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT06757829

• Acupuncture for pain in sickle cell disease

  This trial will test whether traditional needle acupuncture or non‑needle laser acupuncture can reduce pain and change brain and sensory responses in adolescents and adults with sickle cell disease.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06725550

• Training program to help teens with sickle cell pain

  This study is testing a new training program to see if it can help teens with sickle cell disease manage their pain and improve their daily activities.

  Recruiting at 4 sites Emory University · Hartford, Connecticut and 3 other locations · NCT06691867

• A tool to improve family communication in pediatric stem cell transplant decisions

  This study is testing a new tool to help families talk better and make decisions together about stem cell transplants for kids aged 8 to 17.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06689800

• Adapting a fatigue-management program for adults with sickle cell disease

  This trial will test a combined cognitive-behavioral and energy-conservation program (Drépa-FACETS) to reduce fatigue in French-speaking adults with sickle cell disease.

  Recruiting Versailles Hospital · Grenoble and 1 other locations · NCT06650813

• Gene editing of your own blood stem cells to boost fetal hemoglobin for severe sickle cell disease and beta-thalassemia

  This trial will test whether editing a specific gene in patients' own blood stem cells can raise fetal hemoglobin and reduce symptoms in people aged 13–40 with severe sickle cell disease or transfusion-dependent beta-thalassemia.

  Recruiting Phase 1 Boston Children's Hospital · Boston, Massachusetts · NCT06647979

• Using intravenous L-citrulline to treat pain in sickle cell disease

  This study is testing if giving L-citrulline through an IV can help kids and young adults with sickle cell disease feel better faster during painful episodes.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT06635902

• Evaluating Etavopivat for Sickle Cell Disease

  This study is testing if a new drug called etavopivat can help reduce painful crises and improve overall health in adults and teens with sickle cell disease.

  Recruiting at 130 sites Phase 3 Novo Nordisk A/S · Birmingham, Alabama and 174 other locations · NCT06612268

• Long-term treatment with Etavopivat for sickle cell disease and thalassemia

  This study is testing how safe and effective a new medication called Etavopivat is for people with sickle cell disease and thalassemia who have already seen benefits from it.

  Recruiting at 45 sites Phase 3 Novo Nordisk A/S · Birmingham, Alabama and 106 other locations · NCT06609226

• Evaluating Hydroxycarbamide for Children with Sickle Cell Disease

  This study is testing if a new form of Hydroxycarbamide can safely help children with Sickle Cell Disease feel better over a year of treatment.

  Recruiting at 6 sites Phase 2 Theravia · Créteil and 6 other locations · NCT06578507

• CS-206 treatment for sickle cell disease

  This study is testing a new injection called CS-101 to see if it can safely help people with sickle cell disease by boosting their production of fetal hemoglobin.

  Recruiting Early Phase 1 CorrectSequence Therapeutics Co., Ltd · Nanning, Guangxi · NCT06565026

• Resilience support for adolescents and young adults with sickle cell disease

  This project will test a resilience-building program (PRISM) delivered through a collaborative care model for adolescents and young adults with sickle cell disease to see if it is feasible and acceptable.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06555939

• Evaluating ITU512 for Sickle Cell Disease and Healthy Participants

  This study is testing a new drug called ITU512 to see if it is safe and effective for people with sickle cell disease and healthy adults.

  Recruiting at 13 sites Phase 1/2 Novartis · Birmingham, Alabama and 13 other locations · NCT06546670

• Preventing strokes in children with sickle cell disease in Nigeria using hydroxyurea

  This study is testing if hydroxyurea can help prevent strokes in children with sickle cell disease in Nigeria who are at high risk.

  Recruiting at 2 sites Phase 4 Vanderbilt University Medical Center · Kano and 1 other locations · NCT06526117

• Gene editing treatment for sickle cell disease

  This study is testing a new gene editing treatment for people with severe sickle cell disease to see if it can improve their health.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06506461

• Examining sleep and brain function in children with sickle cell disease

  This study is trying to see how sleep quality affects brain function in children with sickle cell disease by using special devices at home and tests at the clinic.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06477289

• Using motixafortide to collect stem cells in sickle cell disease patients

  This study is testing if a new drug called motixafortide can safely help people with sickle cell disease collect stem cells for future treatments.

  Recruiting at 3 sites Phase 1 St. Jude Children's Research Hospital · Birmingham, Alabama and 2 other locations · NCT06442761

• Investigating Crizanlizumab for Sickle Cell Disease in Adolescents and Adults

  This study is testing if a new medication called crizanlizumab can help reduce painful episodes in adolescents and adults with sickle cell disease.

  Recruiting at 35 sites Phase 3 Novartis · Birmingham, Alabama and 35 other locations · NCT06439082

• Gene therapy using BAH243 for treating sickle cell disease

  This study is testing a new gene therapy called BAH243 to see if it can safely help people with sickle cell disease feel better after receiving a stem cell transplant.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06399107

• Finding and Engaging Patients with Sickle Cell Disease

  This study is trying to find people with Sickle Cell Disease who aren't getting the care they need and connect them with support to improve their treatment and quality of life.

  Recruiting at 9 sites RTI International · Birmingham, Alabama and 8 other locations · NCT06385886

• Digital cognitive behavioral therapy with peer support for young adults with sickle cell pain

  This study is testing if a new online therapy with peer support can help young adults with sickle cell disease manage their pain better than standard care.

  Recruiting at 14 sites University of Pittsburgh · Mobile, Alabama and 13 other locations · NCT06374238

• School readiness program for preschool children with sickle cell disease

  This study is testing a special online school readiness program for preschool kids with sickle cell disease to see if it helps them get ready for school better than regular resources.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06367192

• Transplant for Sickle Cell Disease Using a Nonmyeloablative Approach

  This study is testing a new way to help people with sickle cell disease who have certain antibodies receive a safer type of stem cell transplant from a sibling to see if it can improve their chances of recovery.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT06358638

• Improving hydroxyurea use for sickle cell disease in Nigeria

  This study is testing a special training program for healthcare workers in Nigeria to see if it can help more people with sickle cell disease start using hydroxyurea treatment.

  Recruiting New York University · Abuja · NCT06318143

• Understanding red blood cell lifespan in sickle cell disease and hemoglobin disorders

  This study is trying to see how long red blood cells last in people with sickle cell disease and other blood disorders to help improve their treatment.

  Recruiting Early Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06313398

• Mapping the prevalence of sickle cell disease in Uganda

  This study is trying to find out how common sickle cell trait and sickle cell disease are in Uganda by testing blood samples from infants to help improve health strategies for these conditions.

  Recruiting at 4 sites Children's Hospital Medical Center, Cincinnati · Kampala and 3 other locations · NCT06301893

• Zinc supplements for bone health in sickle cell disease

  This 12-week test gives two different daily zinc doses (25 mg or 40 mg) to people aged 15 to 40 with homozygous sickle cell disease to see which dose most changes blood markers of bone turnover.

  Recruiting Phase 2 University of California, San Francisco · Oakland, California and 5 other locations · NCT06260891

• European platform for collecting data on rare anemia disorders

  This study is trying to gather important information from people with rare anemia disorders across Europe to help improve their treatment and care.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Catalonia · NCT06213402

• Evaluating Etavopivat for Pediatric Sickle Cell Disease

  This study is testing a new oral medication called etavopivat in teenagers with sickle cell disease to see how it works in their bodies and if it helps them feel better over 96 weeks.

  Recruiting at 12 sites Phase 2 Novo Nordisk A/S · Toronto, Ontario and 17 other locations · NCT06198712

• Using virtual reality to help manage pain in sickle cell disease patients

  This study is testing if using virtual reality can help adults with sickle cell disease feel less pain during painful episodes.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT06184126

• Non-invasive prenatal diagnosis for single gene disorders

  This study is testing a new way to safely diagnose single-gene disorders in unborn babies using a simple blood test from the mother, starting as early as 9 weeks into the pregnancy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06147414

• Identifying Pain Predictors in Sickle Cell Disease

  This study is trying to find out what factors can predict severe pain in people with sickle cell disease to help improve pain management.

  Recruiting Duke University · Durham, North Carolina · NCT06139510

• Web-based intervention for teens and young adults with sickle cell disease

  This study is testing a mobile app designed to help teens and young adults with sickle cell disease manage their symptoms and improve their overall health.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06035939

• Using alendronate to treat osteonecrosis in adults with sickle cell disease

  This study is testing if a weekly medication called alendronate can help adults with sickle cell disease who have bone pain from osteonecrosis feel better and improve their bone health.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06016634

• Evaluating Etavopivat for Pediatric Sickle Cell Disease Patients at Risk for Stroke

  This study is testing if a new medication called etavopivat can help prevent strokes in kids aged 12 to 16 with sickle cell disease who are at higher risk.

  Recruiting at 4 sites Phase 2 Novo Nordisk A/S · Raipur, Chhattisgarh and 8 other locations · NCT05953584

• Evaluating the safety of fostamatinib for sickle cell disease

  This study is testing whether a new medication called fostamatinib is safe for adults with stable sickle cell disease and if it can help improve their blood cell function and reduce inflammation.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05904093

• Understanding patient needs for gene therapy in sickle cell disease

  This study talks to patients and their families about what they think and need to know about gene therapy for sickle cell disease to help create better educational resources for them.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05810181

• Investigating genetic factors in blood disorders

  This study is trying to find out how genes affect blood disorders like sickle cell disease and thalassemia by looking at the DNA of many people with these conditions.

  Recruiting at 17 sites Cyprus Institute of Neurology and Genetics · Boston, Massachusetts and 25 other locations · NCT05799118

• Immune suppression treatment for sickle cell disease and beta-thalassemia patients receiving stem cell transplants

  This study is testing if a new immune suppression treatment can help people with sickle cell disease or beta-thalassemia have better outcomes when they receive stem cell transplants.

  Recruiting at 6 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT05736419

• Using tocilizumab to treat acute chest syndrome in sickle cell disease

  This study is testing if a low dose of tocilizumab can help people with sickle cell disease who have acute chest syndrome feel better during their hospital stay.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT05640271

• Investigating heart blood flow and function in sickle cell disease

  This study is testing how blood flow and heart function are affected in people with sickle cell disease to see if it leads to heart problems.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05583721

• Using cannabinoids to reduce inflammation and pain in sickle cell disease

  This study is testing if a cannabinoid called dronabinol can help adults with sickle cell disease feel less pain and improve their quality of life.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT05519111

• Evaluating a single dose of CTX001 for treating transfusion-dependent beta-thalassemia and severe sickle cell disease

  This study is testing a single dose of a new treatment called CTX001 to see if it can help people with transfusion-dependent beta-thalassemia or severe sickle cell disease feel better.

  Recruiting at 6 sites Phase 3 Vertex Pharmaceuticals Incorporated · New York, New York and 5 other locations · NCT05477563

• Phase 2/3 testing of osivelotor in adults and adolescents with sickle cell disease.

  This trial tests whether an oral medicine called osivelotor can safely reduce pain crises and improve blood measures in people aged 12–65 with sickle cell disease.

  Recruiting at 38 sites Phase 2/3 Pfizer · Mobile, Alabama and 79 other locations · NCT05431088

• Haploidentical stem cell transplantation for adults with severe sickle cell disease

  This study is testing if a special type of stem cell transplant can help adults with severe sickle cell disease who haven't found relief with other treatments.

  Recruiting Phase 3 King's College Hospital NHS Trust · London · NCT05392894

• Helping young people with sickle cell disease make treatment decisions

  This study is testing a new way to help young people with sickle cell disease and their caregivers make better treatment decisions by using virtual reality alongside regular education materials.

  Recruiting Nemours Children's Clinic · Wilmington, Delaware · NCT05383911

• Early-life exposures and breastfeeding in children with sickle cell disease

  This project will try a community breastfeeding support group for mothers of infants with sickle cell disease to see if breastfeeding and related supports improve early-life exposures and child health.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05377372

• Exploring the effects of exercise on children's health with chronic diseases

  This study is testing how exercise can improve the health of children with chronic diseases like cystic fibrosis and sickle cell disease to find safe ways for them to be active.

  Recruiting University of California, Irvine · Irvine, California · NCT05359991

• Telehealth intervention to help adolescents with sickle cell disease transition to adult care

  This study is testing a telehealth program to help teenagers with sickle cell disease improve their thinking skills and self-care as they transition to adult healthcare.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05336201

• Using Hydroxyurea to Treat Sickle Cell Anemia in Children in Africa

  This study is testing if hydroxyurea can safely help children with sickle cell anemia in Africa feel better and improve their treatment options.

  Recruiting Phase 3 Brown University · Luanda · NCT05285917

• Assessing skin hydration in patients with sickle cell disease

  This study is testing a new skin sensor to see if it can help people with sickle cell disease manage their hydration better, especially during painful episodes.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05210114

• Understanding diet and nutrition in adults with Sickle Cell Disease

  This study looks at how diet and nutrition affect the health of adults with Sickle Cell Disease to see what changes might help them feel better.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05170412

• Training program to improve attention in children with sickle cell disease

  This study is testing a fun, game-like training program to see if it can help children with sickle cell disease improve their attention and thinking skills.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT05099874

• Gene correction therapy for severe sickle cell disease

  This study is testing a new gene therapy called nula-cel to see if it can safely improve the health of young people with severe sickle cell disease.

  Recruiting at 6 sites Phase 1/2 Kamau Therapeutics · Los Angeles, California and 5 other locations · NCT04819841

• Infusion of modified stem cells for severe Sickle Cell Disease

  This study is testing if a new treatment using modified stem cells can safely help young people with severe Sickle Cell Disease.

  Recruiting at 3 sites Phase 1/2 University of California, San Francisco · Davis, California and 2 other locations · NCT04774536

• Continuation of crizanlizumab treatment for sickle cell disease patients

  This study is for people with sickle cell disease who have already tried crizanlizumab and want to keep using it to see how well it works and if it's safe over a longer time.

  Recruiting at 7 sites Phase 4 Novartis · Birmingham, Alabama and 30 other locations · NCT04657822

• Genomic and gene therapy needs for families and patients with sickle cell disease

  This project uses interviews and surveys to see if better information and a web-based tool can help parents and teens with sickle cell disease understand genomic sequencing and treatment options.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04416178

• Long-term observation of non-cancer blood disorders

  This study is tracking people with blood disorders like hemophilia and thrombosis for at least 15 years to see how their conditions change over time and gather useful information for doctors and researchers.

  Recruiting at 74 sites American Thrombosis and Hemostasis Network · Phoenix, Arizona and 75 other locations · NCT04398628

• Haploidentical stem cell transplantation for sickle cell disease

  This study is testing a new type of stem cell transplant for people with sickle cell disease to see if it can cure the disease while causing fewer complications.

  Recruiting at 4 sites Phase 2 University of Regensburg · Vienna and 8 other locations · NCT04201210

• Monitoring brain health in children with Sickle Cell Disease

  This study is trying to see how Sickle Cell Disease affects brain health in children aged 8-18 by using special imaging techniques to check blood flow and oxygen levels in the brain.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04166526

• Understanding brain blood flow and metabolism in children

  This study is trying to see how blood flow and metabolism in the brain affect development in children, especially those with sickle cell disease and stroke, by using advanced MRI techniques.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT04157179

• Stem cell transplantation for blood disorders using specific cell depletion techniques

  This study is testing a new way of using stem cell transplants for children and young adults with blood disorders to see if removing certain cells helps them recover better and improve their quality of life.

  Recruiting Phase 2 New York Medical College · Valhalla, New York · NCT04099966

• Understanding hydroxyurea effects during pregnancy and breastfeeding in women with sickle cell disease

  This study looks at how taking hydroxyurea during pregnancy and breastfeeding affects women with sickle cell disease and their babies to better understand the risks and outcomes.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04093986

• Treatment for high-risk sickle cell disease using nicotinamide and other medications

  This study is testing if a combination of three medications can help people with high-risk sickle cell disease feel better and manage their symptoms more effectively.

  Recruiting Phase 1 EpiDestiny, Inc. · Chicago, Illinois · NCT04055818

• Collecting biological samples to study blood disorders

  This study is collecting samples from people with blood disorders and healthy volunteers to see how certain genetic factors affect these conditions and overall health.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03937817

• Program to help teenagers with sickle cell disease transition to adult care

  This study tests a program designed to help teenagers with sickle cell disease smoothly move from children's healthcare to adult care by providing both medical and emotional support.

  Recruiting Hospices Civils de Lyon · Fort-de-France-La Martinique, La Martinique and 7 other locations · NCT03786549

• Reducing toxicity in sibling donor transplants for children with sickle cell disease

  This study is testing a gentler transplant method for children with sickle cell disease using cells from their siblings to see if it reduces side effects while still helping them stay healthy.

  Recruiting at 7 sites Phase 2 Children's National Research Institute · Washington D.C., District of Columbia and 6 other locations · NCT03587272

• Using virtual reality to manage pain in sickle cell disease crises

  This study is testing if using virtual reality can help people with sickle cell disease feel less pain during painful crises when combined with their usual treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee and 1 other locations · NCT03353584

• Registry for Sickle Cell Disease in German-speaking Europe

  This study is collecting information about people with sickle cell disease in Germany, Austria, and Switzerland to see how the disease affects them and improve future care and treatment.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT03327428

• Nonmyeloablative stem cell transplant for children with sickle cell disease and incompatible donors

  This study is testing a new way to do a stem cell transplant for children with sickle cell disease who have a donor that doesn't perfectly match to see if it can help them get better.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT03214354

• HLA-haploidentical stem cell transplantation for aggressive sickle cell disease

  This study is testing a new type of stem cell transplant to see if it can help people with severe sickle cell disease feel better.

  Recruiting Phase 2 University of Illinois Chicago · Chicago, Illinois · NCT03121001

• Biofluidic chip technology for studying sickle cell disease

  This study is testing a new technology that looks closely at the cells of people with sickle cell disease to better understand how their cells behave and interact.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT02824471

• Investigation of genetics related to blood diseases

  This study is trying to understand the genetics behind blood diseases by collecting samples and health information from people with these conditions and their family members.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT02720679

• Using Defibrotide to Improve Stem Cell Transplant Outcomes for Sickle Cell Disease

  This study is testing if giving Defibrotide before a stem cell transplant can help people with sickle cell disease avoid serious complications and have better outcomes.

  Recruiting at 4 sites Phase 2 New York Medical College · Los Angeles, California and 3 other locations · NCT02675959

• Arginine treatment for pain relief in children with sickle cell disease

  This study is testing if giving arginine to children with sickle cell disease can help reduce their pain during painful episodes and lessen their need for pain medications.

  Recruiting at 2 sites Phase 1/2 Emory University · Atlanta, Georgia and 1 other locations · NCT02447874

• Observational program for sickle cell disease management and outcomes

  This study is tracking people with sickle cell disease from childhood to adulthood to see how their condition changes over time and how treatments like hydroxyurea affect their health.

  Recruiting at 5 sites St. Jude Children's Research Hospital · Peoria, Illinois and 5 other locations · NCT02098863

• Testing panobinostat for treating sickle cell disease

  This study is testing if a new drug called panobinostat can help adults with sickle cell disease who haven't found relief with standard treatment.

  Recruiting Phase 1 Augusta University · Augusta, Georgia · NCT01245179

• Collecting blood samples to study sickle cell disease

  This study is collecting blood samples from healthy people and those with sickle cell disease to see if new drugs can help stop red blood cells from sickling.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00542230

NIH-funded research (newest 40 of 215)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Digital twins of the spleen to help design better therapies for sickle cell disease

  A computer-driven replica of the spleen is being developed to speed up creating safer and more effective treatments for people with sickle cell disease.

  NIH research Brown University · Providence, United States · NIH-11627935

• Accelerating hydroxyurea use for sickle cell disease in Nigeria

  A pragmatic study in Nigeria aims to help doctors use hydroxyurea more consistently for people with sickle cell disease.

  NIH research New York University · New York, United States · NIH-11601755

• Immune and nerve signals behind acupuncture relief for sickle cell pain

  This NIH grant explores how acupuncture helps reduce pain and opioid use for people with sickle cell disease.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11595810

• Mindfulness-based Support for Pain and Sleep in Young People with Sickle Cell Disease

  A digital mindfulness program is being tailored for adolescents and young adults with sickle cell disease to help with pain and sleep and is being tested for practicality and early effectiveness.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11583056

• How diet affects white blood cells and sickle cell disease

  A study looks at how nutrition, from early life to adulthood, influences sickle cell disease by examining neutrophils and disease severity in people with SCD and in a mouse model.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11548417

• Nutrition-based plan to ease pain in sickle cell disease

  A nutrition-based approach is being tested to reduce pain for people living with sickle cell disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11533140

• Understanding how environment and microbiome affect health in children with sickle cell disease

  A research project will explore how environmental exposures shape immune responses and airway microbiomes in children with sickle cell disease and how these factors relate to health outcomes.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11515703

• Gene-editing delivery for sickle cell disease using safer, non-viral nanoparticles

  A researcher is developing a safer, non-viral nanoparticle method to deliver gene edits to a patient’s own blood-forming cells to treat sickle cell disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11451335

• Using Real-World Data to Improve Infection Prevention in Children with Sickle Cell Disease

  This project uses real-world data to understand how current antibiotic and disease-modifying therapies work together to prevent serious infections in children with sickle cell disease.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11451018

• MAP SCD: How place-based factors affect sickle cell disease

  A study to understand how where people live and their daily environment influence the illness and pain in sickle cell disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11449158

• Gut microbiome targets to ease sickle cell pain in patients

  Researchers are studying how gut microbes affect chronic pain in people with sickle cell disease and how penicillin prophylaxis in babies might change pain pathways.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11448997

• Predicting which febrile kids with sickle cell disease are at low risk for bacteremia

  A small, patient-facing prediction rule is being developed to help doctors decide which febrile children with sickle cell disease really need aggressive testing and antibiotics.

  NIH research Yale University · New Haven, United States · NIH-11441291

• Admixture mapping to find genetic modifiers of sickle cell disease in adults

  A study in adults with sickle cell disease will look for inherited genes that change how the disease shows up, beyond the main HbS mutation.

  NIH research Duke University · Durham, United States · NIH-11440602

• Retinal clues to brain injury in children with sickle cell disease

  This study looks at whether eye blood vessels measured with OCT scans can reflect brain injury in kids with sickle cell disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11434144

• Partnering with adolescents and young adults with sickle cell disease in treatment decisions

  This grant explores how to better involve teens and young adults with sickle cell disease in choosing their therapies to improve how well they stick with treatment.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11427469

• Access to preventive dental care may improve health in children with sickle cell disease

  Aiming to see if regular preventive dental visits help improve health outcomes for kids with sickle cell disease who rely on Medicaid.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11426157

• Understanding how individual differences shape pain in sickle cell disease (MIDAS)

  Aims to build a patient-focused model using real-world health data from Black adolescents and young adults with sickle cell disease to better predict and manage severe pain crises.

  NIH research University of Texas Arlington · Arlington, United States · NIH-11419821

• KYC: a new drug aiming to stop painful VOC in adults with sickle cell disease

  A new drug called KYC could help adults with sickle cell disease who come to the ER with painful vaso-occlusive crises by reducing blood vessel blockage and pain.

  NIH research Reneurogen, LLC · Elm Grove, United States · NIH-11419557

• Molecular mechanisms of HIV resistance in people with Sickle Cell Disease and Trait

  A scientist at Howard University is studying why people with sickle cell disease or trait might be more resistant to HIV, in order to uncover clues for better protection and treatment.

  NIH research Howard University · Washington, United States · NIH-11419417

• Donor red blood cells and how long they last in people with sickle cell disease

  This project looks at how donated red blood cells behave after transfusions in people with sickle cell disease to understand why some lasts longer than others.

  NIH research Emory University · Atlanta, United States · NIH-11417949

• RECIPE: Connecting Sickle Cell Patients to Care for Better Outcomes

  A program to help adults with sickle cell disease get the care they need by identifying those not currently seeing a specialist and linking them to guideline-based services.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11417285

• Understanding how platelets behave in sickle cell disease

  A physician-scientist-in-training will study how platelets function differently in people with sickle cell disease to find better ways to prevent painful crises.

  NIH research Yale University · New Haven, United States · NIH-11416538

• Accelerating hydroxyurea adoption for sickle cell disease in Nigeria

  A pragmatic study in Nigeria aims to help more people with sickle cell disease get hydroxyurea, a treatment that reduces painful crises and hospitalizations.

  NIH research New York University · New York, United States · NIH-11415723

• Base editing and prime editing for sickle cell disease

  Aims to improve treatment for adults with sickle cell disease by using precise genome editing to boost fetal hemoglobin or correct the sickle mutation.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11413777

• Sex hormones, inflammation, and pain in sickle cell disease

  This project explores how female hormones may boost inflammation and influence painful episodes in women with sickle cell disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11411236

• Dual nitric oxide donor therapy for sickle cell–related acute chest syndrome

  A new medicine (DMX-201) being developed to help people with sickle cell disease who develop acute chest syndrome by delivering nitric oxide more safely.

  NIH research Dimerx · Mill Valley, United States · NIH-11409179

• Delivering patient-facing guidelines for adults with sickle cell disease using a mobile app and booklets

  A multi-center study will provide adults with sickle cell disease with easy-to-use, evidence-based guidelines through a mobile app and printed booklets.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11402704

• Glycan-based at-home treatment to shorten painful VOEs in sickle cell disease

  A new at-home therapy called IHP-102 aims to modify the disease’s pain crises in adults with sickle cell disease.

  NIH research Ihp Therapeutics, INC. · San Carlos, UNITED STATES · NIH-11402594

• CD39-bearing tiny vesicles may guard lungs in SCD patients

  A study in people with sickle cell disease explores whether extracellular vesicles carrying CD39 protect the lungs from blood clots during acute illness.

  NIH research Versiti Blood Health, INC. · Milwaukee, United States · NIH-11397728

• Sickle Cell Disease Pain Analgesia and Integrative Network for Better Pain Care

  A national network is being built to better understand and manage pain in adults with sickle cell disease using integrative, whole-health approaches.

  NIH research University of California-Irvine · Irvine, United States · NIH-11397510

• Gene editing to raise fetal hemoglobin for sickle cell disease

  A new gene-editing therapy using patient’s own stem cells to boost fetal hemoglobin could potentially correct sickle cell disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11396296

• Transfusion-driven hyperhemolysis in sickle cell disease

  Aimed at understanding why some sickle cell patients have severe, dangerous reactions to blood transfusions and finding ways to prevent it.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11396278

• Bringing hydroxyurea to people with sickle cell disease in Nigeria

  This project helps clinics in Nigeria screen for sickle cell disease and use hydroxyurea more often so people with SCD can get a proven medicine that lowers pain and complications.

  NIH research New York University · New York, United States · NIH-11394743

• Modeling HbS polymerization in sickle cell disease at the single-cell level

  A research project uses computer and lab models to understand how sickle hemoglobin polymerizes inside individual red blood cells, with goal of guiding future treatments for people with sickle cell disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11394205

• RBCs that activate neutrophils in sickle cell disease

  This grant tests how red blood cells from people with sickle cell disease make neutrophils more sticky and inflammatory, which could worsen painful events and organ damage.

  NIH research Duke University · Durham, United States · NIH-11393690

• Factor XII and blood clots in sickle cell disease

  A research project tests how Factor XII affects blood clotting and inflammation in people with sickle cell disease to understand how it contributes to painful crises, clots, and organ damage.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11393008

• Senescence-targeting therapies to boost blood stem cell health in sickle cell disease

  A study tests aging-related treatments to protect and improve blood stem cells in people with sickle cell disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11391434

• Understanding and reducing unintended large gene changes in sickle cell gene editing

  A study in people with sickle cell disease looks at unexpected large DNA changes that can happen when repairing genes with CRISPR and aims to figure out how to prevent them.

  NIH research Rice University · Houston, United States · NIH-11386620

• Chronic dehydration as a warning sign to prevent sickle cell pain crises

  This project looks at whether ongoing mild dehydration can help spot people with sickle cell disease who are more likely to have painful vaso-occlusive crises.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11384061

• Gene editing to raise fetal hemoglobin levels in adults with sickle cell disease

  This project edits a patient’s own blood stem cells with CRISPR to turn on fetal hemoglobin and help adults with sickle cell disease have fewer sickled red cells and painful episodes.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11378801

Related topics

Quick answers

How many Sickle Cell Disease clinical trials are recruiting right now?

124, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in United States (91 trials), France (14 trials), Nigeria (9 trials), United Kingdom (8 trials), Turkey (Türkiye) (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 24, Phase 1/2: 10, Phase 3: 10, Phase 1: 9. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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