Thromboelastometry to Predict Thrombosis and Survival in Glial Tumor Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes whether thromboelastometric values and standard coagulation tests collected after anesthesia induction can identify patients at higher risk of thromboembolic events and poorer survival after glial tumor surgery. It compares patients with hypercoagulable laboratory patterns to those without, in terms of postoperative clots and outcomes. The goal is to see if coagulation profile helps tailor perioperative care and oncologic treatment. Measurements include EXTEM CT, MCF, α-angle, PT, aPTT, fibrinogen, platelet count, and thrombin generation. Participation requires surgical treatment of a suspected glial tumor and informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing surgical excision or biopsy with a diagnostic impression of glial tumor who provide written informed consent

Exclusion Criteria:

* Patients under 18 years of age.
* Emergency surgery.
* Patients receiving antiplatelet or anticoagulant treatment.
* Patients with known hematologic diseases associated with coagulation abnormalities. Examples include:

  * Congenital or acquired platelet function disorders.
  * Congenital deficiency of protein C or protein S.
  * Deficiency of coagulation factors II, V, VII, X, XII.
  * Glanzmann thrombasthenia.
  * Hemophilia A, B, or C.
  * Idiopathic thrombocytopenic purpura (ITP).
  * von Willebrand disease (types I, II, and III).
* Systemic diseases that cause significant coagulation time alterations:

  * Prothrombin time \< 60%.
  * Activated partial thromboplastin time (aPTT) \> 50 seconds.
* Patients with suspected glial or neuroglial tumor in the context of long-standing epilepsy

Where it's running

• Hospital Clínic Barcelona
  Barcelona, Spain Recruiting

Study contacts

• Principal investigator: Paola Hurtado Restrepo, MD, PhD — Hospital Clinic of Barcelona
• Study coordinator: Paola A Hurtado, MD, PhD
• Email: phurtado@clinic.cat
• Phone: 34 932275558

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.